MTCP1 (Mature T Cell Proliferation 1)
1998-03-01 Marc-Henri Stern AffiliationUnité INSERM U462, Centre Hayem, Hopital Saint Louis, 75475 Paris Cedex 10, France
Identity
HGNC
LOCATION
Xq28
IMAGE
LEGEND
MTCP1 (Xq28) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics.
LOCUSID
ALIAS
C6.1B
FUSION GENES
DNA/RNA
DNA Diagram
Description
7 exons; about 10 kb
Transcription
complex; alternative splicing: two donor sites in exon 1;
transcripts A, the most abondant, ubiquitous: splicing from exon 1 to exon
6; transcripts B, rare: splicing from exon 1 to exon 2; initiation of the
transcription: an alternative site of initiation of the transcription in
intron 1 has been found in one tumor with a translocation breakpoint in
intron 1
Proteins
Description
p13 MTCP1: coded by transcripts B, 107 amino acides; one
domain with a b-barrel topology
Expression
protein expression undetectable in physiological conditions
Localisation
cytosol
Function
unknown
Homology
TCL1 (39% identity, similar tridimentional structure)
Implicated in
Entity name
Cytogenetics
associated with i(8q)
Hybrid gene
unconstant TCRA-c6.1A transcripts have been described
Fusion protein
none
Oncogenesis
over expression of p13 MTCP1 is considered as critical in the oncogenetic mechanism
Disease
T-cell prolymphocytic leukemia
Oncogenesis
over expression of p13 MTCP1
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 9405159 | 1997 | Solution structure of human p8MTCP1, a cysteine-rich protein encoded by the MTCP1 oncogene, reveals a new alpha-helical assembly motif. | Barthe P et al |
| 8247530 | 1993 | The chromosomal translocation t(X;14)(q28;q11) in T-cell pro-lymphocytic leukaemia breaks within one gene and activates another. | Fisch P et al |
| 9315101 | 1997 | Alternative origin of p13MTCP1-encoding transcripts in mature T-cell proliferations with t(X;14) translocations. | Gritti C et al |
| 8634440 | 1996 | Expression of p13MTCP1 is restricted to mature T-cell proliferations with t(X;14) translocations. | Madani A et al |
| 7970717 | 1994 | The MTCP-1/c6.1B gene encodes for a cytoplasmic 8 kD protein overexpressed in T cell leukemia bearing a t(X;14) translocation. | Soulier J et al |
| 8152252 | 1994 | A gene on chromosome Xq28 associated with T-cell prolymphocytic leukemia in two patients with ataxia telangiectasia. | Thick J et al |
| 8570215 | 1996 | Expression of either the TCL1 oncogene, or transcripts from its homologue MTCP1/c6.1B, in leukaemic and non-leukaemic T cells from ataxia telangiectasia patients. | Thick J et al |
| 9691281 | 1998 | Solution structure of the recombinant human oncoprotein p13MTCP1. | Yang YS et al |
Other Information
Locus ID:
NCBI: 4515
MIM: 300116
HGNC: 7423
Ensembl: ENSG00000214827
Variants:
dbSNP: 4515
ClinVar: 4515
TCGA: ENSG00000214827
COSMIC: MTCP1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000214827 | ENST00000362018 | P56278 |
| ENSG00000214827 | ENST00000369476 | P56278 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| PI3K-Akt signaling pathway | KEGG | hsa04151 |
| PI3K-Akt signaling pathway | KEGG | ko04151 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34732719 | 2021 | Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia. | 2 |
| 34732719 | 2021 | Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia. | 2 |
| 19064571 | 2008 | Polymorphisms in mitochondrial genes and prostate cancer risk. | 22 |
| 19064571 | 2008 | Polymorphisms in mitochondrial genes and prostate cancer risk. | 22 |
| 17136114 | 2007 | The MTCP1 oncogene modifies T-cell homeostasis before leukemogenesis in transgenic mice. | 5 |
| 17136114 | 2007 | The MTCP1 oncogene modifies T-cell homeostasis before leukemogenesis in transgenic mice. | 5 |
Citation
Marc-Henri Stern
MTCP1 (Mature T Cell Proliferation 1)
Atlas Genet Cytogenet Oncol Haematol. 1998-03-01
Online version: http://atlasgeneticsoncology.org/gene/89/mtcp1
