NONO (non-POU domain containing, octamer-binding)
1999-01-01 Jean-Loup Huret AffiliationGenetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
DNA/RNA
Transcription
alternative splicing; 2.4 mRNA complete cds; coding sequence: CDS 129 ... 1550
Proteins
Description
the protein encoded by NONO is called p54nrb (nuclear RNA binbing); 471 amino acids; 54 kDa; N-term glutamine/histidine rich region, tandem RNA binding domains (amino acids 75 to 228), helix-turn-helix implicated in DNA binding, and a proline rich region in C-term; N-term and C-term allow protein-protein interactions.
Expression
wide
Function
binds independantly to DNA and RNA; forms a heterodimer with PSF, a protein sharing vast homologies; both form complexes with DNA topoisomerase I, which renders this enzyme much more active; NONO also enhances the binding of several DNA-binding proteins (but not all).
Homology
with PSF and other proteins with a DBHS domain (Drosophila behaviour, human splicing) which includes the tandem RNA binding domains.
Implicated in
Entity name
Disease
only one case of papillary renal cell carcinoma
Hybrid gene
5 NONO- 3 TFE3
Fusion protein
N-term NONO and most of it except the C-term proline rich sequence fused to the DNA binding domains of TFE3 (excluding the acidic transcriptional activation domain, including the C-term helix-loop-helix, and the leucine zipper); the reciprocal transcript is found
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 9393982 | 1997 | Fusion of splicing factor genes PSF and NonO (p54nrb) to the TFE3 gene in papillary renal cell carcinoma. | Clark J et al |
| 8371983 | 1993 | Purification and cDNA cloning of HeLa cell p54nrb, a nuclear protein with two RNA recognition motifs and extensive homology to human splicing factor PSF and Drosophila NONA/BJ6. | Dong B et al |
| 9756848 | 1998 | The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interaction. | Straub T et al |
| 8355702 | 1993 | NonO, a non-POU-domain-containing, octamer-binding protein, is the mammalian homolog of Drosophila nonAdiss. | Yang YS et al |
| 9171077 | 1997 | NonO enhances the association of many DNA-binding proteins to their targets. | Yang YS et al |
Other Information
Locus ID:
NCBI: 4841
MIM: 300084
HGNC: 7871
Ensembl: ENSG00000147140
Variants:
dbSNP: 4841
ClinVar: 4841
TCGA: ENSG00000147140
COSMIC: NONO
RNA/Proteins
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38211652 | 2024 | IKZF4/NONO-RAB11FIP3 axis promotes immune evasion in gastric cancer via facilitating PD-L1 endosome recycling. | 0 |
| 38224452 | 2024 | Nucleolar detention of NONO shields DNA double-strand breaks from aberrant transcripts. | 1 |
| 38341127 | 2024 | NONO promotes gallbladder cancer cell proliferation by enhancing oncogenic RNA splicing of DLG1 through interaction with IGF2BP3/RBM14. | 1 |
| 38211652 | 2024 | IKZF4/NONO-RAB11FIP3 axis promotes immune evasion in gastric cancer via facilitating PD-L1 endosome recycling. | 0 |
| 38224452 | 2024 | Nucleolar detention of NONO shields DNA double-strand breaks from aberrant transcripts. | 1 |
| 38341127 | 2024 | NONO promotes gallbladder cancer cell proliferation by enhancing oncogenic RNA splicing of DLG1 through interaction with IGF2BP3/RBM14. | 1 |
| 36416237 | 2023 | NONO enhances mRNA processing of super-enhancer-associated GATA2 and HAND2 genes in neuroblastoma. | 8 |
| 36459792 | 2023 | NONO regulates multiple cytokine production in sepsis via the ERK1/2 signaling pathway. | 0 |
| 36653413 | 2023 | A novel NONO variant that causes developmental delay and cardiac phenotypes. | 1 |
| 37271897 | 2023 | The Conserved LncRNA DIO3OS Restricts Hepatocellular Carcinoma Stemness by Interfering with NONO-Mediated Nuclear Export of ZEB1 mRNA. | 7 |
| 37370134 | 2023 | Non-POU Domain-Containing Octomer-Binding (NONO) protein expression and stability promotes the tumorigenicity and activation of Akt/MAPK/β-catenin pathways in human breast cancer cells. | 3 |
| 36416237 | 2023 | NONO enhances mRNA processing of super-enhancer-associated GATA2 and HAND2 genes in neuroblastoma. | 8 |
| 36459792 | 2023 | NONO regulates multiple cytokine production in sepsis via the ERK1/2 signaling pathway. | 0 |
| 36653413 | 2023 | A novel NONO variant that causes developmental delay and cardiac phenotypes. | 1 |
| 37271897 | 2023 | The Conserved LncRNA DIO3OS Restricts Hepatocellular Carcinoma Stemness by Interfering with NONO-Mediated Nuclear Export of ZEB1 mRNA. | 7 |
Citation
Jean-Loup Huret
NONO (non-POU domain containing, octamer-binding)
Atlas Genet Cytogenet Oncol Haematol. 1999-01-01
Online version: http://atlasgeneticsoncology.org/gene/168/nono
