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NRIP1 (nuclear receptor interacting protein 1)

Written2009-12Michael J Spinella
Department of Pharmacology, Dartmouth Medical School, 7650 Remsen, Hanover NH 03755, USA
Updated2018-04Vincent Cavaillès and Marion Lapierre
IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Université Montpellier, Montpellier F-34298, France.;

Abstract Review on NRIP1, with data on DNA, on the protein encoded, and where the gene is implicated.

Keywords NRIP1; Transcription factor

(Note : for Links provided by Atlas : click)


Alias_symbol (synonym)RIP140
Other aliasFLJ77253
LocusID (NCBI) 8204
Atlas_Id 44067
Location 21q11.2  [Link to chromosome band 21q11]
Location_base_pair Starts at 14961235 and ends at 15064805 bp from pter ( according to hg19-Feb_2009)  [Mapping NRIP1.png]
Local_order Cen-GAPDHP16-LOC100128341-NRIP1-CYCSP42-LOC100131399-Tel
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NRIP1 (21q11.2) / BTBD1 (15q25.2)NRIP1 (21q11.2) / HIBADH (7p15.2)NRIP1 (21q11.2) / MECOM (3q26.2)
NRIP1 (21q11.2) / SHCBP1 (16q11.2)NRIP1 (21q11.2) / UHRF1 (19p13.3)TIAM1 (21q22.11) / NRIP1 (21q11.2)
UBE2V2 (8q11.21) / NRIP1 (21q11.2)


Description The gene encompasses approximately 100 Kb and may contain up to 7 exons. The entire protein-coding region is contained within the last exon.
Transcription Transcription is complex. Alternative spliced transcripts containing distinct combinations of 5' non-coding exons occur. Alternative promoters have been described and are proposed to mediate tissue specific expression of NRIP1. NRIP1 is induced by a number of hormone nuclear receptors including the receptors for estrogen, retinoic acid, androgen, progestins, vitamin D3, peroxisome proliferators-activated receptor-alpha (PPARalpha) and estrogen related receptor-alpha (ERRalpha). NRIP1 gene transcription is also induced by E2F transcription factors.
NRIP1 mRNA is widely expressed in various tissues and cell types.
Pseudogene None known.


Description NRIP1 consists of 1158 amino acids. NRIP1 contains ten LXXLL nuclear receptor interaction motifs and four transcriptional repression domains (RD 1-4). NRIP1 also contains four c-terminal binding protein (CtBP) interaction motifs. NRIP1 activity is regulated by a variety of posttranslational modifications including acetylation, methylation, phosphorylation, sumoylation, and pyridoxal-phosphate (PLP) conjugation.
Expression NRIP1 is expressed at low levels in most tissues and is induced in response to hormonal signals. NRIP1 is highly expressed in metabolic and reproductive organs and tissues including the liver, adipose tissue, skeletal muscle, ovary and endometrium.
Localisation NRIP1 is mainly expressed in the nucleus and contains two putative nuclear localization signals (NLS).
Function NRIP1 is a co-repressor of a large number of nuclear receptors. NRIP1 interacts preferentially with ligand-bound nuclear receptors and inhibits transactivation by recruitment of histone deacetylases and CtBP. Knockout mice studies revealed that NRIP1 has a physiologic role in energy homeostasis, muscle metabolism, adipocyte and hepatocyte function, mitochondrial activity, inflammation, reproduction and cognition. Data suggest that these roles are mediated by NRIP1 repression of nuclear receptor mediated gene expression including gene expression mediated by the estrogen receptor, liver X receptor, PPARs, steroidogenic factor 1 (SF1) and ERR.
NRIP1 has been shown to regulate retinoic acid mediated differentiation and growth suppression of human embryonal carcinoma cells and the proliferation of breast cancer cells in vitro. A potential role for NRIP1 in cancer cachexia has been suggested. Interestingly, NRIP1 also regulates the activity of other transcription factors including E2Fs and NFKB.
The fact that NRIP1 expression can be regulated by multiple transcription factors and especially nuclear receptors and their ligands and that NRIP1 can inhibits the activity of multiple nuclear receptors implies a potential role in the biology of hormone-dependent cancers. This role in cancer biology which has recently been described in colon, stomach, breast and cervix.
Homology NRIP1 is highly conserved throughout vertebrates. There is only a single isoform in humans and mice.


Note Several synonymous and non-synonymous SNPs have been identified. To date no somatic tumor mutations have been noted.
- Arg448Gly has been associated with endometriosis.
- Gly75Gly has been associated with male infertility.

Implicated in

Entity Hormone dependent cancers
Note In a variety of cancer cell culture systems mouse models and tissue arrays, NRIP1 has been shown to regulate the activity of a number of nuclear receptors involved in hormone-dependent cancers including estrogen, retinoid, progesterone and androgen receptors. Moreover, NRIP1 mRNA is finely regulated during cell cycle progression, modulating cell growth and apoptosis. Finally, NRIP1 overexpression is associated with a significantly shorter overall survival of cervical cancer patients and discriminates luminal breast cancers
Entity Cancer cachexia
Note NRIP1 was induced in livers of starved, septic, and tumor-bearing mice. Liver-specific knockdown of NRIP1 led to increased hepatic TG release and alleviated hepatic steatosis in tumor-bearing, cachectic animals. NRIP1 was found to control the expression of lipid-metabolizing genes in liver.
Entity Obesity and metabolic disorders
Note NRIP1 knockout mice are lean and are resistant to high-fat diet induced obesity. NRIP1 regulates genes involved in energy homeostasis in metabolic organs. Moreover, low level of NRIP1 restores the rates of fatty-acids uptake in the basal state, in part via a reduction in upstream insulin signaling. In addition, increased NRIP1 level may be closely associated with inflammation and disorder of lipid and glucose metabolism in diabetic patients. In addition, detectable serum NRIP1 protein level changes is associated with weight loss in humans.
Entity Infertility
Note Female NRIP1 knockout mice are infertile due to a defect in ovulation. Also the above-mentioned SNPs have been proposed to be associated with endometriosis and male fertility.
Entity Gastro-intestinal homeostasis and tumorigenesis
Note Using molecular and cellular approaches, transgenic mouse models and human colorectal biopsies, NRIP1 has been shown to inhibit cell proliferation and apoptosis in the murine intestinal epithelium. In addition, NRIP1 exerts a negative control on Wnt/beta-catenin signaling by positively regulating the expression of the tumor suppressor gene APC. High NRIP1 expression is associated with a significantly longer overall survival of colorectal cancer patients. Interestingly, whereas NRIP1 expression tends to decrease in colorectal cancers as compared to adjacent normal tissues, an increase of its expression was noticed in gastric cancer as compared to normal stomach.
Entity Cognition and neural cells
Note The NRIP1 gene depletion in mice results in learning and memory deficits as well as stress response, bringing to light a major role for this transcriptional coregulator in the neurophysiological developmental mechanisms underlying cognitive functions. In addition, NRIP1 plays a relevant role in Down syndrome mitochondrial dysfunction. Moreover, NRIP1 expression increases during neural differentiation of human embryonic stem cells and is negatively correlated with stem cell markers Oct4 and Sox2 during early stages of neural differentiation.
Entity Aging and longevity
Note The deletion of NRIP1 in female mice can significantly extend longevity compared to wild-type females
Entity Immunity and inflammation
Note Overexpression of NRIP1 in macrophages results in M1like polarization and expansion during the inflammatory response. Conversely, decreased expression of NRIP1 in macrophages reduces the number of M1like macrophages and increases the number of alternatively polarized cells, which collectively promote endotoxin tolerance and relieve inflammation.


Transcriptional regulation of the human NRIP1/RIP140 gene by estrogen is modulated by dioxin signalling
Augereau P, Badia E, Fuentes M, Rabenoelina F, Corniou M, Derocq D, Balaguer P, Cavailles V
Mol Pharmacol 2006 Apr;69(4):1338-46
PMID 16391242
Suppressing NRIP1 inhibits growth of breast cancer cells in vitro and in vivo
Aziz MH, Chen X, Zhang Q, DeFrain C, Osland J, Luo Y, Shi X, Yuan R
Oncotarget 2015 Nov 24;6(37):39714-24
PMID 26492163
Nuclear receptor cofactor receptor interacting protein 140 controls hepatic triglyceride metabolism during wasting in mice
Berriel Diaz M, Krones-Herzig A, Metzger D, Ziegler A, Vegiopoulos A, Klingenspor M, Müller-Decker K, Herzig S
Hepatology 2008 Sep;48(3):782-91
The nuclear cofactor receptor interacting protein-140 (RIP140) regulates the expression of genes involved in Aβ generation
Blondrath K, Steel JH, Katsouri L, Ries M, Parker MG, Christian M, Sastre M
Neurobiol Aging 2016 Nov;47:180-191
PMID 27614112
Preliminary molecular genetic analysis of the Receptor Interacting Protein 140 (RIP140) in women affected by endometriosis
Caballero V, Ruiz R, Sainz JA, Cruz M, López-Nevot MA, Galán JJ, Real LM, de Castro F, López-Villaverde V, Ruiz A
J Exp Clin Assist Reprod 2005 Aug 30;2:11
PMID 16131398
Genome-wide analysis of estrogen receptor binding sites
Carroll JS, Meyer CA, Song J, Li W, Geistlinger TR, Eeckhoute J, Brodsky AS, Keeton EK, Fertuck KC, Hall GF, Wang Q, Bekiranov S, Sementchenko V, Fox EA, Silver PA, Gingeras TR, Liu XS, Brown M
Nat Genet 2006 Nov;38(11):1289-97
PMID 17013392
Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor
Cavaillès V, Dauvois S, L'Horset F, Lopez G, Hoare S, Kushner PJ, Parker MG
EMBO J 1995 Aug 1;14(15):3741-51
PMID 7641693
Amelioration of palmitate-induced metabolic dysfunction in L6 muscle cells expressing low levels of receptor-interacting protein 140
Constantinescu S, Turcotte LP
Can J Physiol Pharmacol 2015 Nov;93(11):913-22
PMID 26406163
Regulation of Nuclear Receptor Interacting Protein 1 (NRIP1) Gene Expression in Response to Weight Loss and Exercise in Humans
De Marinis Y, Sun J, Bompada P, Domènech Omella J, Luan C, Halu A, Renström E, Sharma A, Ridderstråle M
Obesity (Silver Spring) 2017 Aug;25(8):1400-1409
PMID 28656645
Negative regulation of estrogen signaling by ERβ and RIP140 in ovarian cancer cells
Docquier A, Garcia A, Savatier J, Boulahtouf A, Bonnet S, Bellet V, Busson M, Margeat E, Jalaguier S, Royer C, Balaguer P, Cavaillès V
Mol Endocrinol 2013 Sep;27(9):1429-41
PMID 23885094
Cognitive impairments in adult mice with constitutive inactivation of RIP140 gene expression
Duclot F, Lapierre M, Fritsch S, White R, Parker MG, Maurice T, Cavaillès V
Genes Brain Behav 2012 Feb;11(1):69-78
PMID 21906262
Absence of RIP140 reveals a pathway regulating glut4-dependent glucose uptake in oxidative skeletal muscle through UCP1-mediated activation of AMPK
Fritah A, Steel JH, Parker N, Nikolopoulou E, Christian M, Carling D, Parker MG
PLoS One 2012;7(2):e32520
PMID 22389706
Multilocus analyses of estrogen-related genes reveal involvement of the ESR1 gene in male infertility and the polygenic nature of the pathology
Galan JJ, Buch B, Cruz N, Segura A, Moron FJ, Bassas L, Martinez-Pineiro L, Real LM, Ruiz A
Fertil Steril 2005 Oct;84(4):910-8
PMID 16213843
Altered progesterone receptor isoform expression remodels progestin responsiveness of breast cancer cells
Graham JD, Yager ML, Hill HD, Byth K, O'Neill GM, Clarke CL
Mol Endocrinol 2005 Nov;19(11):2713-35
PMID 15976005
Retinoic acid mediates long-paced oscillations in retinoid receptor activity: evidence for a potential role for RIP140
Heim KC, Gamsby JJ, Hever MP, Freemantle SJ, Loros JJ, Dunlap JC, Spinella MJ
PLoS One 2009 Oct 28;4(10):e7639
PMID 19862326
Selective repression of retinoic acid target genes by RIP140 during induced tumor cell differentiation of pluripotent human embryonal carcinoma cells
Heim KC, White KA, Deng D, Tomlinson CR, Moore JH, Freemantle SJ, Spinella MJ
Mol Cancer 2007 Sep 19;6:57
PMID 17880687
The nuclear receptor cofactor, receptor-interacting protein 140, is required for the regulation of hepatic lipid and glucose metabolism by liver X receptor
Herzog B, Hallberg M, Seth A, Woods A, White R, Parker MG
Mol Endocrinol 2007 Nov;21(11):2687-97
PMID 17684114
Cholesterol regulation of receptor-interacting protein 140 via microRNA-33 in inflammatory cytokine production
Ho PC, Chang KC, Chuang YS, Wei LN
FASEB J 2011 May;25(5):1758-66
PMID 21285396
Biological activities of receptor-interacting protein 140 in adipocytes and metabolic diseases
Ho PC, Wei LN
Curr Diabetes Rev 2012 Nov;8(6):452-7
PMID 22934550
Overexpression of RIP140 suppresses the malignant potential of hepatocellular carcinoma by inhibiting NFB‑mediated alternative polarization of macrophages
Hu YC, Yi ZJ, Zhou Y, Li PZ, Liu ZJ, Duan SG, Gong JP
Oncol Rep 2017 May;37(5):2971-2979
PMID 28393222
Lysine methylation of nuclear co-repressor receptor interacting protein 140
Huq MD, Ha SG, Barcelona H, Wei LN
J Proteome Res 2009 Mar;8(3):1156-67
PMID 19216533
NRIP1/RIP140 siRNA-mediated attenuation counteracts mitochondrial dysfunction in Down syndrome
Izzo A, Manco R, Bonfiglio F, Cal G, De Cristofaro T, Patergnani S, Cicatiello R, Scrima R, Zannini M, Pinton P, Conti A, Nitsch L
Hum Mol Genet 2014 Aug 15;23(16):4406-19
PMID 24698981
Complex regulation of LCoR signaling in breast cancer cells
Jalaguier S, Teyssier C, Nait Achour T, Lucas A, Bonnet S, Rodriguez C, Elarouci N, Lapierre M, Cavaillès V
Oncogene 2017 Aug 17;36(33):4790-4801
PMID 28414308
RIP140 as a novel therapeutic target in the treatment of atherosclerosis
Karasawa T, Takahashi M
J Mol Cell Cardiol 2015 Apr;81:136-8
PMID 25701715
Transcriptional activation of the nuclear receptor corepressor RIP140 by retinoic acid: a potential negative-feedback regulatory mechanism
Kerley JS, Olsen SL, Freemantle SJ, Spinella MJ
Biochem Biophys Res Commun 2001 Jul 27;285(4):969-75
PMID 11467847
The emerging role of the transcriptional coregulator RIP140 in solid tumors
Lapierre M, Docquier A, Castet-Nicolas A, Gitenay D, Jalaguier S, Teyssier C, Cavaillès V
Biochim Biophys Acta 2015 Aug;1856(1):144-50
PMID 26116758
NOP14 suppresses breast cancer progression by inhibiting NRIP1/Wnt/β-catenin pathway
Lei JJ, Peng RJ, Kuang BH, Yuan ZY, Qin T, Liu WS, Guo YM, Han HQ, Lian YF, Deng CC, Zhang HJ, Chen LZ, Feng QS, Xu M, Feng L, Bei JX, Zeng YX
Oncotarget 2015 Sep 22;6(28):25701-14
PMID 26213846
Nuclear receptor corepressor RIP140 regulates fat accumulation
Leonardsson G, Steel JH, Christian M, Pocock V, Milligan S, Bell J, So PW, Medina-Gomez G, Vidal-Puig A, White R, Parker MG
Proc Natl Acad Sci U S A 2004 Jun 1;101(22):8437-42
PMID 15155905
Expression profiling in squamous carcinoma cells reveals pleiotropic effects of vitamin D3 analog EB1089 signaling on cell proliferation, differentiation, and immune system regulation
Lin R, Nagai Y, Sladek R, Bastien Y, Ho J, Petrecca K, Sotiropoulou G, Diamandis EP, Hudson TJ, White JH
Mol Endocrinol 2002 Jun;16(6):1243-56
PMID 12040012
Gut microbiota from metabolic disease-resistant, macrophage-specific RIP140 knockdown mice improves metabolic phenotype and gastrointestinal integrity
Lin YW, Montassier E, Knights D, Wei LN
Sci Rep 2016 Dec 8;6:38599
PMID 27929078
Reducing RIP140 expression in macrophage alters ATM infiltration, facilitates white adipose tissue browning, and prevents high-fat diet-induced insulin resistance
Liu PS, Lin YW, Lee B, McCrady-Spitzer SK, Levine JA, Wei LN
Diabetes 2014 Dec;63(12):4021-31
PMID 24969109
Overexpression and potential roles of NRIP1 in psoriasis
Luan C, Chen X, Hu Y, Hao Z, Osland JM, Chen X, Gerber SD, Chen M, Gu H, Yuan R
Oncotarget 2016 Nov 8;7(45):74236-74246
PMID 27708240
Post-translational modifications of nuclear co-repressor RIP140: a therapeutic target for metabolic diseases
Mostaqul Huq MD, Gupta P, Wei LN
Curr Med Chem 2008;15(4):386-92
PMID 18288993
Distinct functions for RIP140 in development, inflammation, and metabolism
Nautiyal J, Christian M, Parker MG
Trends Endocrinol Metab 2013 Sep;24(9):451-9
PMID 23742741
RIP140 expression is stimulated by estrogen-related receptor alpha during adipogenesis
Nichol D, Christian M, Steel JH, White R, Parker MG
J Biol Chem 2006 Oct 27;281(43):32140-7
PMID 16923809
Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes
Powelka AM, Seth A, Virbasius JV, Kiskinis E, Nicoloro SM, Guilherme A, Tang X, Straubhaar J, Cherniack AD, Parker MG, Czech MP
J Clin Invest 2006 Jan;116(1):125-36
PMID 16374519
SUMOylation modulates the transcription repressor function of RIP140
Rytinki MM, Palvimo JJ
J Biol Chem 2008 Apr 25;283(17):11586-95
PMID 18211901
The transcriptional corepressor RIP140 regulates oxidative metabolism in skeletal muscle
Seth A, Steel JH, Nichol D, Pocock V, Kumaran MK, Fritah A, Mobberley M, Ryder TA, Rowlerson A, Scott J, Poutanen M, White R, Parker M
Cell Metab 2007 Sep;6(3):236-45
PMID 17767910
RIP140 and LCoR expression in gastrointestinal cancers
Triki M, Ben Ayed-Guerfali D, Saguem I, Charfi S, Ayedi L, Sellami-Boudawara T, Cavailles V, Mokdad-Gargouri R
Oncotarget 2017 Nov 25;8(67):111161-111175
PMID 29340045
Expression and role of nuclear receptor coregulators in colorectal cancer
Triki M, Lapierre M, Cavailles V, Mokdad-Gargouri R
World J Gastroenterol 2017 Jul 7;23(25):4480-4490
PMID 28740336
Investigation of RIP140 and LCoR as independent markers for poor prognosis in cervical cancer
Vattai A, Cavailles V, Sixou S, Beyer S, Kuhn C, Peryanova M, Heidegger H, Hermelink K, Mayr D, Mahner S, Dannecker C, Jeschke U, Kost B
Oncotarget 2017 Oct 31;8(62):105356-105371
PMID 29285256
Acetylation of nuclear hormone receptor-interacting protein RIP140 regulates binding of the transcriptional corepressor CtBP
Vo N, Fjeld C, Goodman RH
Mol Cell Biol 2001 Sep;21(18):6181-8
PMID 11509661
Deletion of Nrip1 extends female mice longevity, increases autophagy, and delays cell senescence
Wang J, Chen X, Osland J, Gerber DS, Luan C, Delfino K, Goodwin L, Yuan R
J Gerontol A Biol Sci Med Sci 2018 Jan 13
PMID 29346516
Receptor-interacting protein 140 directly recruits histone deacetylases for gene silencing
Wei LN, Hu X, Chandra D, Seto E, Farooqui M
J Biol Chem 2000 Dec 29;275(52):40782-7
PMID 11006275
Limiting effects of RIP140 in estrogen signaling: potential mediation of anti-estrogenic effects of retinoic acid
White KA, Yore MM, Deng D, Spinella MJ
J Biol Chem 2005 Mar 4;280(9):7829-35
PMID 15632153
The nuclear receptor co-repressor nrip1 (RIP140) is essential for female fertility
White R, Leonardsson G, Rosewell I, Ann Jacobs M, Milligan S, Parker M
Nat Med 2000 Dec;6(12):1368-74
PMID 11100122
Role of RIP140 in metabolic tissues: connections to disease
White R, Morganstein D, Christian M, Seth A, Herzog B, Parker MG
FEBS Lett 2008 Jan 9;582(1):39-45
PMID 18023280
Synergistic effect of receptor-interacting protein 140 and simvastatin on the inhibition of proliferation and survival of hepatocellular carcinoma cells
Xia K, Zhang P, Hu J, Hou H, Xiong M, Xiong J, Yan N
Oncol Lett 2018 Apr;15(4):4344-4350
PMID 29541202
RIP140 is associated with subclinical inflammation in type 2 diabetic patients
Xue J, Zhao H, Shang G, Zou R, Dai Z, Zhou D, Huang Q, Xu Y
Exp Clin Endocrinol Diabetes 2013 Jan;121(1):37-42
PMID 22956256
Transcriptional co-regulator RIP140: An important mediator of the inflammatory response and its associated diseases (Review)
Yi ZJ, Gong JP, Zhang W
Mol Med Rep 2017 Aug;16(2):994-1000
PMID 28586037
Correlation between receptor-interacting protein 140 expression and directed differentiation of human embryonic stem cells into neural stem cells
Zhao ZR, Yu WD, Shi C, Liang R, Chen X, Feng X, Zhang X, Mu Q, Shen H, Guo JZ
Neural Regen Res 2017 Jan;12(1):118-124
PMID 28250757


This paper should be referenced as such :
Vincent Cavaills, Marion Lapierre
NRIP1 (nuclear receptor interacting protein 1)
Atlas Genet Cytogenet Oncol Haematol. 2018;22(12):479-483.
Free journal version : [ pdf ]   [ DOI ]
On line version :
History of this paper:
Spinella, MJ. NRIP1 (nuclear receptor interacting protein 1). Atlas Genet Cytogenet Oncol Haematol. 2010;14(10):923-925.

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(3;21)(q26;q11) NRIP1/MECOM

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]
  Lung: Translocations in Squamous Cell Carcinoma
t(7;21)(p15;q21) NRIP1/HIBADH
t(8;21)(q11;q21) UBE2V2/NRIP1
t(16;21)(q11;q21) NRIP1/SHCBP1
t(21;21)(q21;q22) TIAM1/NRIP1

External links

HGNC (Hugo)NRIP1   8001
Entrez_Gene (NCBI)NRIP1  8204  nuclear receptor interacting protein 1
AliasesCAKUT3; RIP140
GeneCards (Weizmann)NRIP1
Ensembl hg19 (Hinxton)ENSG00000180530 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000180530 [Gene_View]  ENSG00000180530 [Sequence]  chr21:14961235-15064805 [Contig_View]  NRIP1 [Vega]
ICGC DataPortalENSG00000180530
TCGA cBioPortalNRIP1
Genatlas (Paris)NRIP1
SOURCE (Princeton)NRIP1
Genetics Home Reference (NIH)NRIP1
Genomic and cartography
GoldenPath hg38 (UCSC)NRIP1  -     chr21:14961235-15064805 -  21q11.2-q21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)NRIP1  -     21q11.2-q21.1   [Description]    (hg19-Feb_2009)
GoldenPathNRIP1 - 21q11.2-q21.1 [CytoView hg19]  NRIP1 - 21q11.2-q21.1 [CytoView hg38]
Mapping of homologs : NCBINRIP1 [Mapview hg19]  NRIP1 [Mapview hg38]
OMIM602490   618270   
Gene and transcription
Genbank (Entrez)AK123818 AK289786 BC040361 BE792046 HF584749
RefSeq transcript (Entrez)NM_003489
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)NRIP1
Cluster EST : UnigeneHs.155017 [ NCBI ]
CGAP (NCI)Hs.155017
Alternative Splicing GalleryENSG00000180530
Gene ExpressionNRIP1 [ NCBI-GEO ]   NRIP1 [ EBI - ARRAY_EXPRESS ]   NRIP1 [ SEEK ]   NRIP1 [ MEM ]
Gene Expression Viewer (FireBrowse)NRIP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8204
GTEX Portal (Tissue expression)NRIP1
Human Protein AtlasENSG00000180530-NRIP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP48552   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP48552  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP48552
Splice isoforms : SwissVarP48552
Domains : Interpro (EBI)NRIP1    NRIP1_RD1    NRIP1_RD2    NRIP1_RD3    NRIP1_RD4   
Domain families : Pfam (Sanger)NRIP1_repr_1 (PF15687)    NRIP1_repr_2 (PF15688)    NRIP1_repr_3 (PF15689)    NRIP1_repr_4 (PF15690)   
Domain families : Pfam (NCBI)pfam15687    pfam15688    pfam15689    pfam15690   
Conserved Domain (NCBI)NRIP1
DMDM Disease mutations8204
Blocks (Seattle)NRIP1
PDB (RSDB)2GPO    2GPP    4S14    4S15    5NTI    5NTN    5NTW    5NU1   
PDB Europe2GPO    2GPP    4S14    4S15    5NTI    5NTN    5NTW    5NU1   
PDB (PDBSum)2GPO    2GPP    4S14    4S15    5NTI    5NTN    5NTW    5NU1   
PDB (IMB)2GPO    2GPP    4S14    4S15    5NTI    5NTN    5NTW    5NU1   
Structural Biology KnowledgeBase2GPO    2GPP    4S14    4S15    5NTI    5NTN    5NTW    5NU1   
SCOP (Structural Classification of Proteins)2GPO    2GPP    4S14    4S15    5NTI    5NTN    5NTW    5NU1   
CATH (Classification of proteins structures)2GPO    2GPP    4S14    4S15    5NTI    5NTN    5NTW    5NU1   
Human Protein Atlas [tissue]ENSG00000180530-NRIP1 [tissue]
Peptide AtlasP48552
IPIIPI00010196   IPI00795603   
Protein Interaction databases
IntAct (EBI)P48552
Ontologies - Pathways
Ontology : AmiGOhistone deacetylase complex  negative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  nuclear chromatin  RNA polymerase II proximal promoter sequence-specific DNA binding  ovarian follicle rupture  transcription coactivator activity  transcription coactivator activity  transcription coactivator activity  transcription corepressor activity  transcription corepressor activity  protein binding  nucleus  nucleus  nucleoplasm  nucleolus  circadian rhythm  nuclear speck  lipid storage  estrogen receptor binding  estrogen receptor binding  androgen receptor signaling pathway  circadian regulation of gene expression  circadian regulation of gene expression  nuclear hormone receptor binding  glucocorticoid receptor binding  glucocorticoid receptor binding  histone deacetylase binding  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  retinoid X receptor binding  androgen receptor binding  cellular response to estradiol stimulus  cellular response to estradiol stimulus  
Ontology : EGO-EBIhistone deacetylase complex  negative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  nuclear chromatin  RNA polymerase II proximal promoter sequence-specific DNA binding  ovarian follicle rupture  transcription coactivator activity  transcription coactivator activity  transcription coactivator activity  transcription corepressor activity  transcription corepressor activity  protein binding  nucleus  nucleus  nucleoplasm  nucleolus  circadian rhythm  nuclear speck  lipid storage  estrogen receptor binding  estrogen receptor binding  androgen receptor signaling pathway  circadian regulation of gene expression  circadian regulation of gene expression  nuclear hormone receptor binding  glucocorticoid receptor binding  glucocorticoid receptor binding  histone deacetylase binding  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  retinoid X receptor binding  androgen receptor binding  cellular response to estradiol stimulus  cellular response to estradiol stimulus  
REACTOMEP48552 [protein]
REACTOME PathwaysR-HSA-9018519 [pathway]   
NDEx NetworkNRIP1
Atlas of Cancer Signalling NetworkNRIP1
Wikipedia pathwaysNRIP1
Orthology - Evolution
GeneTree (enSembl)ENSG00000180530
Phylogenetic Trees/Animal Genes : TreeFamNRIP1
Homologs : HomoloGeneNRIP1
Homology/Alignments : Family Browser (UCSC)NRIP1
Gene fusions - Rearrangements
Fusion : MitelmanNRIP1/HIBADH [21q11.2/7p15.2]  
Fusion : MitelmanNRIP1/MECOM [21q11.2/3q26.2]  [t(3;21)(q26;q21)]  
Fusion : MitelmanNRIP1/SHCBP1 [21q11.2/16q11.2]  [t(16;21)(q11;q21)]  
Fusion : MitelmanTIAM1/NRIP1 [21q22.11/21q11.2]  [t(21;21)(q21;q22)]  
Fusion : MitelmanUBE2V2/NRIP1 [8q11.21/21q11.2]  [t(8;21)(q11;q21)]  
Fusion PortalNRIP1 21q11.2 HIBADH 7p15.2 BRCA
Fusion PortalNRIP1 21q11.2 SHCBP1 16q11.2 BRCA
Fusion PortalTIAM1 21q22.11 NRIP1 21q11.2 BRCA
Fusion : FusionGDB24857    24858    24859    24860    24861    24862    24863    24864    24865    24866    38076    9992   
Fusion : Fusion_HubAF127936.9--NRIP1    C7ORF60--NRIP1    CXORF38--NRIP1    DIP2A--NRIP1    EVI1--NRIP1    FAM108C1--NRIP1    LINC00478--NRIP1    LINC02246--NRIP1    MECOM--NRIP1    MRPL39--NRIP1    NRIP1--AF127936.7    NRIP1--APP    NRIP1--ARHGEF26    NRIP1--BTBD1    NRIP1--CSNK1G1   
NRIP1--USP25    NRIP1--YLPM1    TIAM1--NRIP1    UHRF1--NRIP1   
Fusion : QuiverNRIP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerNRIP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NRIP1
Exome Variant ServerNRIP1
ExAC (Exome Aggregation Consortium)ENSG00000180530
GNOMAD BrowserENSG00000180530
Varsome BrowserNRIP1
Genetic variants : HAPMAP8204
Genomic Variants (DGV)NRIP1 [DGVbeta]
DECIPHERNRIP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisNRIP1 
ICGC Data PortalNRIP1 
TCGA Data PortalNRIP1 
Broad Tumor PortalNRIP1
OASIS PortalNRIP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNRIP1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DNRIP1
Mutations and Diseases : HGMDNRIP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NRIP1
DgiDB (Drug Gene Interaction Database)NRIP1
DoCM (Curated mutations)NRIP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NRIP1 (select a term)
NCG5 (London)NRIP1
Cancer3DNRIP1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
OMIM602490    618270   
Genetic Testing Registry NRIP1
NextProtP48552 [Medical]
Target ValidationNRIP1
Huge Navigator NRIP1 [HugePedia]
snp3D : Map Gene to Disease8204
BioCentury BCIQNRIP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8204
Chemical/Pharm GKB GenePA31780
Clinical trialNRIP1
canSAR (ICR)NRIP1 (select the gene name)
DataMed IndexNRIP1
PubMed129 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 21:44:42 CET 2019

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