ZNF146 (zinc finger protein 146)

2000-10-01   Gérard.Goubin 

Laboratoire dOncogenöse, UMR147 CNRS, Section de recherche, Institut Curie, Paris, France

Identity

HGNC
LOCATION
19q13.12
LOCUSID
ALIAS
OZF
FUSION GENES

Proteins

Description

33 kDa; a kruppel zinc finger protein consisting of 10 zinc finger motives, preceeded by 10 amino acids and followed by 2 amino acids

Expression

in most proliferating tissues

Localisation

nucleus

Function

represse gene expression through a consensus motive

Implicated in

Disease
tumors of the exocrine pancreas
Cytogenetics
amplification of the 19q13.1 region in a subset of pancreatic tumors

Bibliography

Pubmed IDLast YearTitleAuthors
81071291994The OZF gene encodes a protein consisting essentially of zinc finger motifs.Le Chalony C et al

Other Information

Locus ID:

NCBI: 7705
MIM: 601505
HGNC: 12931
Ensembl: ENSG00000167635

Variants:

dbSNP: 7705
ClinVar: 7705
TCGA: ENSG00000167635
COSMIC: ZNF146

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167635ENST00000443387Q15072
ENSG00000167635ENST00000456324Q15072

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
158388712005Zinc finger protein overexpressed in colon carcinoma interacts with the telomeric protein hRap1.4
158816732005A Kruppel zinc finger of ZNF 146 interacts with the SUMO-1 conjugating enzyme UBC9 and is sumoylated in vivo.2

Citation

Gérard.Goubin

ZNF146 (zinc finger protein 146)

Atlas Genet Cytogenet Oncol Haematol. 2000-10-01

Online version: http://atlasgeneticsoncology.org/gene/267/znf146