| Description | 2414 amino acids; 264 kDa |
| Expression | widely expressed ; also expressed in the whole embryo; possesses from N term to C term: a nuclear localization signal, a poly-serine, a bromodomain, a poly-glu, a binding region for E1A adenovirus, and a poly-gln. |
| Localisation | nucleus |
| Function | p300 and CBP are highly related proteins implicated in transcriptional responses to various extracellular and intracellular signals with chromatin remodeling; they are non-DNA-binding transcriptional coactivators; they interact with transcriptional activators as well as repressors; p300 and CBP are involved in most cellular programs, including growth, terminal differentiation , and P53-mediated apoptosis (with MDM2 interaction) processes; p300 and CBP appear to have distinct functions during differentiation; there is embryonic lethality of mice nullizygous for p300 (with defects in neurulation and heart development), and as well of mice double heterozygous for p300 and CBP, underlining their essential and associated role |
| Homology | CBP |
| Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. |
| Eckner R, Ewen ME, Newsome D, Gerdes M, DeCaprio JA, Lawrence JB, Livingston DM |
| Genes Dev. 1994 ; 15 : 869-884. |
| PMID 95011587 |
| |
| p300 and CBP as transcriptional regulators and targets of oncogenic events. |
| Eckner R |
| Biological chemistry. 1996 ; 377 (11) : 685-688. |
| PMID 8960368 |
| |
| Adenoviral E1A-associated protein p300 is involved in acute myeloid leukemia with t(11;22)(q23;q13). |
| Ida K, Kitabayashi I, Taki T, Taniwaki M, Noro K, Yamamoto M, Ohki M, Hayashi Y |
| Blood. 1997 ; 90 (12) : 4699-4704. |
| PMID 9389684 |
| |
| Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. |
| Yao TP, Oh SP, Fuchs M, Zhou ND, Ch'ng LE, Newsome D, Bronson RT, Li E, Livingston DM, Eckner R |
| Cell. 1998 ; 93 (3) : 361-372. |
| PMID 9590171 |
| |
| Conjunction dysfunction: CBP/p300 in human disease. |
| Giles RH, Peters DJ, Breuning MH |
| Trends in genetics : TIG. 1998 ; 14 (5) : 178-183. |
| PMID 9613201 |
| |
| p300/MDM2 complexes participate in MDM2-mediated p53 degradation. |
| Grossman SR, Perez M, Kung AL, Joseph M, Mansur C, Xiao ZX, Kumar S, Howley PM, Livingston DM |
| Molecular cell. 1998 ; 2 (4) : 405-415. |
| PMID 9809062 |
| |
| Cell cycle regulation of the transcriptional coactivators p300 and CREB binding protein. |
| Snowden AW, Perkins ND |
| Biochemical pharmacology. 1998 ; 55 (12) : 1947-1954. |
| PMID 9714314 |
| |
| The coactivators p300 and CBP have different functions during the differentiation of F9 cells. |
| Ugai H, Uchida K, Kawasaki H, Yokoyama KK |
| Journal of molecular medicine (Berlin, Germany). 1999 ; 77 (6) : 481-494. |
| PMID 10475063 |
| |
| p300 and CBP: partners for life and death. |
| Giordano A, Avantaggiati ML |
| Journal of cellular physiology. 1999 ; 181 (2) : 218-230. |
| PMID 10497301 |
| |