PRDX1 (peroxiredoxin 1)

2000-12-01 Jean-Loup Huret Affiliation

Identity

HGNC

PRDX1

LOCATION

1p34.1

LOCUSID

5052

ALIAS

MSP23,NKEF-A,NKEFA,PAG,PAGA,PAGB,PRX1,PRXI,TDPX2

FUSION GENES

Show Gene Fusions

DNA/RNA

Description

6 exons, 13 kb

Transcription

937 bp mRNA; 599 bp coding sequence

Pseudogene

pseudogene in 9p22

Proteins

Description

199 amino acids; 22 kDa; form dimers through a disulfide bridge

Expression

widely expressed, in particular in the various cell types of the central nervous system and in red blood cells; overexpressed following induction of proliferation and oxidative stress

Localisation

cytosolic

Function

antioxidant, against oxidative stress; Abl SH3-binding protein; inhibitor of c-Abl tyrosine kinase activity; also binds to heme

Homology

thioperoxiredoxines

Implicated in

Disease

Correlations between the expression level and the stage of tumor progrssion in squamous cell carcinoma of the oral cavity; high expression in follicular thyroid tumors, but not in papillary carcinoma of the thyroid

Bibliography

Pubmed ID	Last Year	Title	Authors
10535922	1999	Crystal structure of a multifunctional 2-Cys peroxiredoxin heme-binding protein 23 kDa/proliferation-associated gene product.	Hirotsu S et al
9497358	1998	Characterization of a mammalian peroxiredoxin that contains one conserved cysteine.	Kang SW et al
10729633	2000	Peroxiredoxin I (macrophage 23 kDa stress protein) is highly and widely expressed in the rat nervous system.	Mizusawa H et al
9506838	1998	The pag gene product, a physiological inhibitor of c-abl tyrosine kinase, is overexpressed in cells entering S phase and by contact with agents inducing oxidative stress.	Prospéri MT et al
10494109	1999	Differential expression of peroxiredoxin subtypes in human brain cell types.	Sarafian TA et al
8691079	1996	Recombinant natural killer enhancing factor augments natural killer cytotoxicity.	Sauri H et al
7702627	1995	Antioxidant function of recombinant human natural killer enhancing factor.	Sauri H et al
8026862	1994	Cloning and sequence analysis of candidate human natural killer-enhancing factor genes.	Shau H et al
8123050	1994	Identification of natural killer enhancing factor as a major antioxidant in human red blood cells.	Shau H et al
9334312	1997	The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity.	Wen ST et al
10840156	2000	Peroxiredoxin I expression in oral cancer: a potential new tumor marker.	Yanagawa T et al

Other Information

Locus ID:

NCBI: 5052
MIM: 176763
HGNC: 9352
Ensembl: ENSG00000117450

Variants:

dbSNP: 5052
ClinVar: 5052
TCGA: ENSG00000117450
COSMIC: PRDX1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000117450	ENST00000262746	Q06830
ENSG00000117450	ENST00000262746	A0A384NPQ2
ENSG00000117450	ENST00000319248	Q06830
ENSG00000117450	ENST00000319248	A0A384NPQ2
ENSG00000117450	ENST00000372079	A0A0A0MRQ5
ENSG00000117450	ENST00000424390	A0A0A0MSI0
ENSG00000117450	ENST00000447184	A0A0A0MSI0

Expression (GTEx)

100

200

300

400

500

600

700

800

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Peroxisome	KEGG	ko04146
Peroxisome	KEGG	hsa04146
Disease	REACTOME	R-HSA-1643685
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Transcriptional Regulation by TP53	REACTOME	R-HSA-3700989
TP53 Regulates Metabolic Genes	REACTOME	R-HSA-5628897
Cellular responses to stress	REACTOME	R-HSA-2262752
Detoxification of Reactive Oxygen Species	REACTOME	R-HSA-3299685
Neurodegenerative Diseases	REACTOME	R-HSA-8863678
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	REACTOME	R-HSA-8862803

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
15105503	2004	Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD.	264
12714748	2003	Reversing the inactivation of peroxiredoxins caused by cysteine sulfinic acid formation.	144
12161445	2002	Inactivation of human peroxiredoxin I during catalysis as the result of the oxidation of the catalytic site cysteine to cysteine-sulfinic acid.	135
15448164	2004	Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine.	124
18606987	2008	HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation.	103
11904290	2002	Proteomics analysis of cellular response to oxidative stress. Evidence for in vivo overoxidation of peroxiredoxins at their active site.	88
22902630	2012	Peroxiredoxin 1 functions as a signal peroxidase to receive, transduce, and transmit peroxide signals in mammalian cells.	80
17234762	2007	Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation: implication to tumor biology.	78
12650976	2003	Aberrant expression of peroxiredoxin subtypes in neurodegenerative disorders.	77
11986303	2002	Regulation of peroxiredoxin I activity by Cdc2-mediated phosphorylation.	62

Citation

Jean-Loup Huret

PRDX1 (peroxiredoxin 1)

Atlas Genet Cytogenet Oncol Haematol. 2000-12-01

Online version: http://atlasgeneticsoncology.org/gene/266/prdx1

Historical Card

2000-10-01 PRDX1 (peroxiredoxin 1) by Maité P Prosperi,Didier Ferbus,Gérard.Goubin Affiliation

Laboratoire dOncogenese, UMR147 CNRS, Section de recherche, Institut Curie, Paris, France.