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PRDM2 (PR domain containing 2, with ZNF domain)

Written2008-03Erika Di Zazzo, Bruno Moncharmont
Dipartimento di Scienze per la Salute, Università degli studi del Molise, Via Francesco De Sanctis - edificio polifunzionale III, 86170 Campobasso, Italia

(Note : for Links provided by Atlas : click)


Alias_namesPR domain containing 2, with ZNF domain
PR domain 2
Alias_symbol (synonym)RIZ
Other aliasGATA 3 binding protein
MTB-ZF(MTE-binding protein zinc-finger)
RIZ (retinoblastoma interacting zinc-finger protein)
LocusID (NCBI) 7799
Atlas_Id 41834
Location 1p36.21  [Link to chromosome band 1p36]
Location_base_pair Starts at 13704855 and ends at 13788079 bp from pter ( according to hg19-Feb_2009)  [Mapping PRDM2.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GALNT18 (11p15.3) / PRDM2 (1p36.21)GALNT18 (11p15.4) / PRDM2 (1p36.21)GATAD2A (19p13.11) / PRDM2 (1p36.21)
PRDM2 (1p36.21) / TFG (3q12.2)ZDHHC21 (9p22.3) / PRDM2 (1p36.21)


Description Spans 150 Kb; 5156 bp coding sequence; 13 exons.
Transcription Two promoters localized, respectively, in exon 1 and exon 6 guide the synthesis of two transcripts: the first one encodes for the PR domain-containing product (RIZ1) and the other one for the PR domain-lacking form (RIZ2).


Description RIZ1(280 kDa) and RIZ2(260 kDa) differ only for the presence in the larger form (RIZ1) of the PR domain. In the sequence of both proteins have been identified several domains:
  • PR domain (130 aa), endowed with histone-methyltransferase activity (Lys 9 of histone H3) and implicated in protein-protein interactions;
  • E1A like-domain (100 aa), contains the LXCXE sequence able to interact with the oncosupressor gene Rb;
  • two zinc-finger clusters;
  • proline-rich domain, containing a LXXLL motif mediating the interaction with estrogen receptor.
  • Expression RIZ1 and RIZ2 have an ubiquitous and approximately equimolar expression with higher expression levels in neuroendocrine tissues.
    Localisation nuclear
    Function RIZ Gene products are endowed with DNA-binding as well as transcription factor-binding activities, as evidenced by the independent isolation of RIZ as a retinoblastoma-binding protein (RIZ), a DNA-binding protein (MTB-Zf), or as a GATA3 transcription factor binding protein (G3B).
    MTB-Zf (essentially identical to RIZ2) binds to the MTE DNA element GTCATATGAC of human heme-oxygenase-1 gene and can weakly activate transcription.
    G3B (RIZ) interacts with the transcription factor GATA-3, regulating the expression of several genes critical for T-cell function and development.
    RIZ proteins bind the estrogen receptor in a hormone-dependent manner, acting as a co-activator.
    Estradiol binding to estrogen receptor complex converts RIZ activity from transcriptional repressor into co-activator.
    Specific siRNA silencing of RIZ1 form increases the MCF-7 breast cancer cells growth rate.
    RIZ proteins act as transcriptional repressors binding to GC-rich or Sp-1-binding elements.


    Germinal RIZ1 K.O. mice showed a high incidence of diffuse large B-cell lymphomas and a broad spectrum of unusual tumors.
    Somatic Deletion of the 1p36 region is frequent in several human cancers including neuroblastoma, breast cancer, intestinal tumors, and malignant melanoma.
    Frameshift mutations in the two poly adenine tracts, A(8) and A(9), generating truncated RIZ1/2 proteins lacking the COOH-terminal PR-binding motif, were found in MSI-high (MSI-H) primary cancers occurring in the pancreas, stomach, endometrium and colorectum.
    The single base substitution that changed A563 in the coding sequence (immediately C-terminal to the PR domain) to a G was found specially in diffuse large B-cell lymphomas (DLBL).
    Missense mutation of RIZ1 changing nucleotide G317 to A were discovered in Saos2 human osteosarcoma cells.
    RIZ harbors a naturally occurring CCT insertion/deletion polymorphism in exon 8 producing a proline insertion/deletion, modulating the impact of estradiol on bone mineral density (BMD).

    Implicated in

    Entity Breast cancer
    Disease The RIZ gene might have a role in human breast cancer. In fact, RIZ1 expression is decreased or lost in human breast cancer, whereas RIZ2 expression is normal.
    Entity Gastric cancer
    Disease RIZ1 might be a specific target of inactivation in human gastric cancer. Methylation of the RIZ1 promoter was detected in 37% of 30 cases and inactivation of the second allele occurred through frameshift mutation, loss of heterozygosity (LOH) or promoter methylation. Furthermore frameshift mutations in the two coding polyadenosine tracks of RIZ were found in 19 (48%) of 40 gastric carcinomas.
    Entity Endometrial carcinoma
    Disease RIZ inactivation is highly selected during the clonal evolution of these tumors. Six (33%) of 18 endometrial carcinomas present frameshift mutation in the two coding polyadenosine tracts of RIZ.
    Entity Colorectal carcinoma
    Disease RIZ might have a role in human colorectal tumorigenesis. The region 1p36 is frequently deleted in colorectal cancer; Furthermore, 37.5% of microsatellite-unstable colorectal tumors presents frameshift mutation, consisting of 1- or 2-bp deletions of a coding (A)8 or (A)9 tract, of the RIZ gene.
    Entity Leukaemia
    Disease Suppression of RIZ1 expression or enhancement of RIZ2 expression may have an important role in leukaemogenesis. The expression of RIZ1 was significantly decreased in leukaemia cell lines (14 out of 17, 82%) and in patients with acute myeloblastic leukaemia (8 out of 14, 57%). In contrast, RIZ2 expression was increased in patients with acute lymphoblastic leukaemia (8 out of 11, 73%) compared with normal bone marrow cells.
    Entity Ovarian carcinoma
    Disease Reduced expression of RIZ1 may play an important role in the pathogenesis and/or development of epithelial ovarian carcinoma, and is considered to be caused in part by aberrant DNA methylation. Decreased expression of RIZ1 was significantly correlated with histological subtypes (P < 0.0001), high tumor grade (P = 0.0153), advanced clinical stage (P = 0.0345), and high Ki67 index (P = 0.0117).
    Entity Neuroblastoma
    Disease Advanced stages of neuroblastoma is genetically characterized by deletions or LOH for the short arm of chromosome 1 suggesting that in the deleted region there is a locus for putative suppressor gene.
    Entity Hepatoma
    Disease Hepatomas present deletion of the chromosome 1 short arm suggesting that in this region is localized a gene whose functional loss may be involved in hepatocellular carcinogenesis.
    Entity Prostate cancer
    Disease RIZ1 may be associated with prostate carcinogenesis. Transcriptional inactivation of RIZ1 gene by aberrant DNA methylation of promoter CpG island is detected in 20 (42.6%) of the 47 prostate cancer tissues.
    Entity Thyroid carcinoma
    Disease RIZ1 have probably an important role in thyroid tumorigenesis. RIZ1 is lost in thyroid tumor cell line and is also significantly reduced in thyroid carcinomas when compared with normal thyroid tissues and benign tumors. The loss of RIZ1 is mediated by aberrant cytosine methylation of the RIZ1 promoter.
    Entity Lung cancer
    Disease RIZ polymorphisms may be an important predictive markers for lung cancer susceptibility. In fact, the +92337G > A and +95701C > A polymorphisms are associated with reduced risk of lung adenocarcinomas.
    Entity Ostheoporosis
    Disease The RIZ P704 insertion (+)/deletion (-) polymorphism modulates the impact of estradiol on bone mineral density (BMD). The RIZ P704 +/+ genotype is a risk factor for low BMD in elderly subjects with low estradiol levels, whereas the RIZ P704 +/+ genotype was associated with high BMD in premenopausal women.


    The retinoblastoma-interacting zinc-finger protein RIZ is a downstream effector of estrogen action.
    Abbondanza C, Medici N, Nigro V, Rossi V, Gallo L, Piluso G, Belsito A, Roscigno A, Bontempo P, Puca AA, Molinari AM, Moncharmont B, Puca GA.
    Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3130-5.
    PMID 10706618
    Decreased expression of RIZ1 and its clinicopathological significance in epithelial ovarian carcinoma: correlation with epigenetic inactivation by aberrant DNA methylation.
    Akahira J, Suzuki F, Suzuki T, Miura I, Kamogawa N, Miki Y, Ito K, Yaegashi N, Sasano H.
    Pathol Int. 2007 Nov;57(11):725-33.
    PMID 17922684
    Deletion of 1p36 as a primary chromosomal aberration in intestinal tumorigenesis.
    Bardi G, Pandis N, Fenger C, Kronborg O, Bomme L, Heim S.
    Cancer Res. 1993 Apr 15;53(8):1895-8.
    PMID 8467511
    In vitro analysis of the E1A-hompologous sequences of RIZ.
    Buyse IM, Huang S.
    J Virol. 1997 Aug;71(8):6200-3.
    PMID 9223517
    The retinoblastoma protein binds to RIZ, a zinc-finger protein that shares an epitope with the adenovirus E1A protein.
    Buyse IM, Shao G, Huang S.
    Proc. Natl. Acad. Sci. U. S. A. 1995 May 9;92(10):4467-71.
    PMID 7538672
    The tumor suppressor gene RIZ in cancer gene therapy.
    Canote R, Du Y, Carling T, Tian F, Peng Z, Huang S.
    Oncol Rep. 2002 Jan-Feb;9(1):57-60. (REVIEW)
    PMID 11748455
    A histone methyltransferase is required for maximal response to female sex hormones.
    Carling T, Kim KC, Yang XH, Gu J, Zhang XK, Huang S.
    Mol Cell Biol. 2004 Aug;24(16):7032-42.
    PMID 15282304
    Candidate tumor suppressor RIZ is frequently involved in colorectal carcinogenesis.
    Chadwick RB, Jiang GL, Bennington GA, Yuan B, Johnson CK, Stevens MW, Niemann TH, Peltomaki P, Huang S, de la Chapelle A.
    Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2662-7.
    PMID 10688904
    Loss of alleles from the distal short arm of chromosome 1 occurs late in melanoma tumor progression.
    Dracopoli NC, Harnett P, Bale SJ, Stanger BZ, Tucker MA, Housman DE, Kefford RF.
    Proc Natl Acad Sci U S A. 1989 Jun;86(12):4614-8.
    PMID 2734311
    Hypermethylation in human cancers of the RIZ1 tumor suppressor gene, a member of a histone/protein methyltransferase superfamily.
    Du Y, Carling T, Fang W, Piao Z, Sheu JC, Huang S.
    Cancer Res. 2001 Nov 15;61(22):8094-9.
    PMID 11719434
    Mapping of a minimal deleted region in human hepatocellular carcinoma to 1p36.13-p36.23 and mutational analysis of the RIZ (PRDM2) gene localized to the region.
    Fang W, Piao Z, Simon D, Sheu JC, Huang S.
    Genes Chromosomes Cancer. 2000 Jul;28(3):269-75.
    PMID 10862032
    Loss of heterozygosity for chromosomes 1 or 14 defines subsets of advanced neuroblastomas.
    Fong CT, White PS, Peterson K, Sapienza C, Cavenee WK, Kern SE, Vogelstein B, Cantor AB, Look AT, Brodeur GM.
    Cancer Res. 1992 Apr 1;52(7):1780-5.
    PMID 1551108
    Modulation of RIZ gene expression is associated to estradiol control of MCF-7 breast cancer cell proliferation.
    Gazzerro P, Abbondanza C, D'Arcangelo A, Rossi M, Medici N, Moncharmont B, Puca GA.
    Exp Cell Res. 2006 Feb 1;312(3):340-9.
    PMID 16356493
    Distal deletion of chromosome Ip in ductal carcinoma of the breast.
    Genuardi M, Tsihira H, Anderson DE, Saunders GF.
    Am J Hum Genet. 1989 Jul;45(1):73-82.
    PMID 2545098
    The impact of estradiol on bone mineral density is modulated by the specific estrogen receptor-alpha cofactor retinoblastoma-interacting zinc finger protein-1 insertion/deletion polymorphism.
    Grundberg E, Akesson K, Kindmark A, Gerdhem P, Holmberg A, Mellström D, Ljunggren O, Orwoll E, Mallmin H, Ohlsson C, Brändström H.
    J Clin Endocrinol Metab. 2007 Jun;92(6):2300-6.
    PMID 17356055
    DNA methylation of the RIZ1 gene is associated with nuclear accumulation of p53 in prostate cancer.
    Hasegawa Y, Matsubara A, Teishima J, Seki M, Mita K, Usui T, Oue N, Yasui W.
    Cancer Sci. 2007 Jan;98(1):32-6.
    PMID 17052263
    RIZ1, but not the alternative RIZ2 product of the same gene, is underexpressed in breast cancer, and forced RIZ1 expression causes G2-M cell cycle arrest and/or apoptosis.
    He L, Yu JX, Liu L, Buyse IM, Wang MS, Yang QC, Nakagawara A, Brodeur GM, Shi YE, Huang S.
    Cancer Res. 1998 Oct 1;58(19):4238-44.
    PMID 9766644
    The retinoblastoma protein-interacting zinc finger gene RIZ in 1p36-linked cancers.
    Huang S.
    Font Biosci. 1999 Jun 15;4:D528-32.
    PMID 10369808
    Decreased RIZ1 expression but not RIZ2 in hepatoma andsuppression of hepatoma tumorigenicity by RIZ1.
    Jiang G, Liu L, Buyse IM, Simon D, Huang S.
    Int J Cancer 1999 Nov 12;83(4):541-6.
    PMID 10508492
    RIZ1 is epigenetically inactivated by promoter hypermethylation in thyroid carcinoma.
    Lal G, Padmanabha L, Smith BJ, Nicholson RM, Howe JR, O’Dorisio MS, Domann FE Jr.
    Cancer. 2006 Dec 15;107(12):2752-9.
    PMID 17103461
    The retinoblastoma interacting zinc finger gene RIZ produces a PR domain-lacking product through an internal promoter.
    Liu L, Shao G, Steele-Perkins G, Huang S.
    J Biol Chem. 1997 Jan 31;272(5):2984-91.
    PMID 9006946
    Identification of a DNA binding protein cooperating with estrogen receptor as RIZ (retinoblastoma interacting zinc finger protein).
    Medici N, Abbondanza C, Nigro V, Rossi V, Piluso G, Belsito A, Gallo L, Roscigno A, Bontempo P, Puca AA, Molinari AM, Moncharmont B, Puca GA.
    Biochem Biophys Res Commun. 1999 Nov 2;264(3):983-9.
    PMID 10544042
    cDNA cloning of a novel protein containing two zinc-finger domains that may function as a transcription factor for the human heme-oxygenase-1 gene.
    Muraosa Y, Takahashi K, Yoshizawa M, Shibahara S.
    Eur. J. Biochem. 1996 Feb 1;235(3):471-9.
    PMID 8654390
    Detection and cloning of a common region of loss of heterozygosity at chromosome 1p in breast cancer.
    Nagai H, Negrini M, Carter SL, Gillum DR, Rosenberg AL, Schwartz GF, Croce CM.
    Cancer Res. 1995 Apr 15;55(8):1752-7.
    PMID 7712484
    Frequent frameshift mutations of RIZ in sporadic gastrointestinal and endometrial carcinomas with microsatellite instability.
    Piao Z, Fang W, Malkhosyan S, Kim H, Horii A, Perucho M, Huang S.
    Cancer Res. 2000 Sep 1;60(17):4701-4.
    PMID 10987271
    RIZ, the retinoblastoma protein interacting zinc finger gene, is mutated in genetically unstable cancers of the pancreas, stomach, and colorectum.
    Sakurada K, Furukawa T, Kato Y, Kayama T, Huang S, Horii A.
    Genes Chromosomes Cancer. 2001 Feb;30(2):207-11.
    PMID 11135439
    Altered expression of retinoblastoma protein-interacting zinc finger gene, RIZ, in human leukaemia.
    Sasaki O, Meguro K, Tohmiya Y, Funato T, Shibahara S, Sasaki T.
    Br J Haematol. 2002 Dec;119(4):940-8.
    PMID 12472571
    Abnormalities of chromosome 1 and loss of heterozygosity on 1p in primary hepatomas.
    Simon D, Knowles BB, Weith A.
    Oncogene. 1991 May;6(5):765-70.
    PMID 1646986
    Identification and cloning of the G3B cDNA encoding a 3' segment of a protein binding 1:o GATA-3.
    Smith Shapiro V, Lee P, Winoto A.
    Gene 1995 Oct 3;163(2):329-30.
    PMID 7590293
    Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein-methyltransferase superfamily.
    Steele-Perkins G, Fang W, Yang X, Van Gele M, Carling T, Gu J, Buyse IM, Fletcher JA, Liu J, Bronson R, Chadwick RB, de la Chapelle A, Zhang X, Speleman F, Huang S.
    Genes Dev. 2001 Sep 1;15(17):2250-62.
    PMID 11544182
    Biallelic inactivation of the RIZ1 gene in human gastric cancer.
    Tokumaru Y, Nomoto S, JerÓnimo C, Henrique R, Harden S, Trink B and Sidransky D.
    Oncogene. 2003 Oct 9;22(44):6954-8.
    PMID 14534544
    Transcriptional repression mediated by the PR domain zinc finger gene RIZ.
    Xie M, Shao G, Buyse IM, Huang S.
    J Biol Chem. 1997 Oct 17;272(42):26360-6.
    PMID 9334209
    Genetic polymorphisms in the Rb-binding zinc finger gene RIZ and the risk of lung cancer.
    Yoon KA, Park S, Hwangbo B, Shin HD, Cheong HS, Shin HR, Lee JS.
    Carcinogenesis. 2007 Sep;28(9):1971-7.
    PMID 17693662


    This paper should be referenced as such :
    Di, Zazzo E ; Montcharmont, B
    PRDM2 (PR domain containing 2, with ZNF domain)
    Atlas Genet Cytogenet Oncol Haematol. 2009;13(1):24-27.
    Free journal version : [ pdf ]   [ DOI ]
    On line version :

    Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
      t(1;11)(p36;p15) GALNT18/PRDM2

    External links

    HGNC (Hugo)PRDM2   9347
    Entrez_Gene (NCBI)PRDM2  7799  PR/SET domain 2
    AliasesHUMHOXY1; KMT8; KMT8A; MTB-ZF; 
    RIZ; RIZ1; RIZ2
    GeneCards (Weizmann)PRDM2
    Ensembl hg19 (Hinxton)ENSG00000116731 [Gene_View]
    Ensembl hg38 (Hinxton)ENSG00000116731 [Gene_View]  ENSG00000116731 [Sequence]  chr1:13704855-13788079 [Contig_View]  PRDM2 [Vega]
    ICGC DataPortalENSG00000116731
    TCGA cBioPortalPRDM2
    AceView (NCBI)PRDM2
    Genatlas (Paris)PRDM2
    SOURCE (Princeton)PRDM2
    Genetics Home Reference (NIH)PRDM2
    Genomic and cartography
    GoldenPath hg38 (UCSC)PRDM2  -     chr1:13704855-13788079 +  1p36.21   [Description]    (hg38-Dec_2013)
    GoldenPath hg19 (UCSC)PRDM2  -     1p36.21   [Description]    (hg19-Feb_2009)
    GoldenPathPRDM2 - 1p36.21 [CytoView hg19]  PRDM2 - 1p36.21 [CytoView hg38]
    Mapping of homologs : NCBIPRDM2 [Mapview hg19]  PRDM2 [Mapview hg38]
    Gene and transcription
    Genbank (Entrez)AB208877 AI651991 AK123605 AK124197 AK293725
    RefSeq transcript (Entrez)NM_001007257 NM_001135610 NM_012231 NM_015866
    RefSeq genomic (Entrez)
    Consensus coding sequences : CCDS (NCBI)PRDM2
    Cluster EST : UnigeneHs.371823 [ NCBI ]
    CGAP (NCI)Hs.371823
    Alternative Splicing GalleryENSG00000116731
    Gene ExpressionPRDM2 [ NCBI-GEO ]   PRDM2 [ EBI - ARRAY_EXPRESS ]   PRDM2 [ SEEK ]   PRDM2 [ MEM ]
    Gene Expression Viewer (FireBrowse)PRDM2 [ Firebrowse - Broad ]
    SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
    GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
    BioGPS (Tissue expression)7799
    GTEX Portal (Tissue expression)PRDM2
    Human Protein AtlasENSG00000116731-PRDM2 [pathology]   [cell]   [tissue]
    Protein : pattern, domain, 3D structure
    UniProt/SwissProtQ13029   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
    NextProtQ13029  [Sequence]  [Exons]  [Medical]  [Publications]
    With graphics : InterProQ13029
    Splice isoforms : SwissVarQ13029
    Domaine pattern : Prosite (Expaxy)SET (PS50280)    ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
    Domains : Interpro (EBI)RIZ_retinblastoma-bd_prot    SET_dom    Znf_C2H2_sf    Znf_C2H2_type   
    Domain families : Pfam (Sanger)SET (PF00856)   
    Domain families : Pfam (NCBI)pfam00856   
    Domain families : Smart (EMBL)SET (SM00317)  ZnF_C2H2 (SM00355)  
    Conserved Domain (NCBI)PRDM2
    DMDM Disease mutations7799
    Blocks (Seattle)PRDM2
    PDB (RSDB)2JV0    2QPW   
    PDB Europe2JV0    2QPW   
    PDB (PDBSum)2JV0    2QPW   
    PDB (IMB)2JV0    2QPW   
    Structural Biology KnowledgeBase2JV0    2QPW   
    SCOP (Structural Classification of Proteins)2JV0    2QPW   
    CATH (Classification of proteins structures)2JV0    2QPW   
    Human Protein Atlas [tissue]ENSG00000116731-PRDM2 [tissue]
    Peptide AtlasQ13029
    IPIIPI00219556   IPI00759628   IPI00953063   IPI00908472   IPI00016780   IPI00479627   IPI00472974   IPI00965685   IPI00965046   IPI00965749   IPI00964508   IPI00964781   
    Protein Interaction databases
    DIP (DOE-UCLA)Q13029
    IntAct (EBI)Q13029
    Ontologies - Pathways
    Ontology : AmiGORNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA-binding transcription factor activity  DNA-binding transcription factor activity  nucleus  nucleus  nucleus  Golgi apparatus  regulation of transcription, DNA-templated  zinc ion binding  determination of adult lifespan  histone-lysine N-methyltransferase activity  chromatin DNA binding  histone lysine methylation  sequence-specific DNA binding  positive regulation of transcription by RNA polymerase II  
    Ontology : EGO-EBIRNA polymerase II regulatory region sequence-specific DNA binding  RNA polymerase II regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA-binding transcription factor activity  DNA-binding transcription factor activity  nucleus  nucleus  nucleus  Golgi apparatus  regulation of transcription, DNA-templated  zinc ion binding  determination of adult lifespan  histone-lysine N-methyltransferase activity  chromatin DNA binding  histone lysine methylation  sequence-specific DNA binding  positive regulation of transcription by RNA polymerase II  
    NDEx NetworkPRDM2
    Atlas of Cancer Signalling NetworkPRDM2
    Wikipedia pathwaysPRDM2
    Orthology - Evolution
    GeneTree (enSembl)ENSG00000116731
    Phylogenetic Trees/Animal Genes : TreeFamPRDM2
    Homologs : HomoloGenePRDM2
    Homology/Alignments : Family Browser (UCSC)PRDM2
    Gene fusions - Rearrangements
    Fusion : MitelmanGALNT18/PRDM2 [11p15.3/1p36.21]  [t(1;11)(p36;p15)]  
    Fusion PortalGALNTL4 PRDM2 1p36.21 SKCM
    Fusion : FusionGDB14314    14437    28601    28602    37008    42696   
    Fusion : Fusion_HubAGAP3--PRDM2    ARID1A--PRDM2    C12ORF75--PRDM2    CHN2--PRDM2    DACT3--PRDM2    GALNTL4--PRDM2    GATAD2A--PRDM2    HIAT1--PRDM2    PRDM2--AADACL4    PRDM2--ADARB1    PRDM2--ARID1A    PRDM2--BCAR3    PRDM2--C1ORF63    PRDM2--CHD2    PRDM2--DYSF   
    PRDM2--ENOSF1    PRDM2--ERRFI1    PRDM2--ETV5    PRDM2--HP1BP3    PRDM2--LRRC38    PRDM2--NCOA5    PRDM2--PAPPA2    PRDM2--PCDH7    PRDM2--PDZK1    PRDM2--PUM1    PRDM2--RER1    PRDM2--RP11-356N1.1.1(VAV3-AS1)    PRDM2--RPS4X    PRDM2--SETD2    PRDM2--SMAP2   
    PRDM2--STAT5B    PRDM2--TFG    PRDM2--TG    PRDM2--TMEM56    PRDM2--YBX3    TRDN--PRDM2    WWP2--PRDM2    ZDHHC21--PRDM2    ZNF644--PRDM2   
    Fusion : QuiverPRDM2
    Polymorphisms : SNP and Copy number variants
    NCBI Variation ViewerPRDM2 [hg38]
    dbSNP Single Nucleotide Polymorphism (NCBI)PRDM2
    Exome Variant ServerPRDM2
    ExAC (Exome Aggregation Consortium)ENSG00000116731
    GNOMAD BrowserENSG00000116731
    Varsome BrowserPRDM2
    Genetic variants : HAPMAP7799
    Genomic Variants (DGV)PRDM2 [DGVbeta]
    DECIPHERPRDM2 [patients]   [syndromes]   [variants]   [genes]  
    CONAN: Copy Number AnalysisPRDM2 
    ICGC Data PortalPRDM2 
    TCGA Data PortalPRDM2 
    Broad Tumor PortalPRDM2
    OASIS PortalPRDM2 [ Somatic mutations - Copy number]
    Somatic Mutations in Cancer : COSMICPRDM2  [overview]  [genome browser]  [tissue]  [distribution]  
    Somatic Mutations in Cancer : COSMIC3DPRDM2
    Mutations and Diseases : HGMDPRDM2
    LOVD (Leiden Open Variation Database)Whole genome datasets
    LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
    LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
    BioMutasearch PRDM2
    DgiDB (Drug Gene Interaction Database)PRDM2
    DoCM (Curated mutations)PRDM2 (select the gene name)
    CIViC (Clinical Interpretations of Variants in Cancer)PRDM2 (select a term)
    NCG5 (London)PRDM2
    Cancer3DPRDM2(select the gene name)
    Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
    Genetic Testing Registry PRDM2
    NextProtQ13029 [Medical]
    Target ValidationPRDM2
    Huge Navigator PRDM2 [HugePedia]
    snp3D : Map Gene to Disease7799
    BioCentury BCIQPRDM2
    Clinical trials, drugs, therapy
    Chemical/Protein Interactions : CTD7799
    Chemical/Pharm GKB GenePA33715
    Clinical trialPRDM2
    canSAR (ICR)PRDM2 (select the gene name)
    DataMed IndexPRDM2
    PubMed81 Pubmed reference(s) in Entrez
    GeneRIFsGene References Into Functions (Entrez)
    REVIEW articlesautomatic search in PubMed
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