Description | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal-associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. This PTP was found to interact with, and dephosphorylate Fas receptor, as well as IkappaBalpha through the PDZ domains, which suggested its role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathway. Eight spliced and the unspliced mRNAs putatively encode good proteins. |
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| Schematic representation of PTPN13 structure and boxes represent functional domains. The KIND domain has been identified in silico by sequence homology. |
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Expression | In all human normal tissues, including lymph node and peripheral blood mononuclear cells samples, PTPN13 is ubiquitously expressed. |
Localisation | The FERM domain binds to phosphatidylinositol 4,5-biphosphate leading to the enrichment of PTPN13 at a juxtamembrane localization. However, the PTPN13 protein is also detected throughout the cytoplasm. In HeLa cells, PTPN13 localizes to the centrosomes during metaphase. |
Function | Functionally, the gene has been tested for association to diseases (Bone Neoplasms; Carcinoma; Colorectal Neoplasms; Liver Neoplasms; lymphoma; Sarcoma, Ewing's ), proposed to participate in a pathway (FAS signaling pathway ( CD95 )) and a process (protein amino acid dephosphorylation). Proteins are expected to have molecular functions (non-membrane spanning protein tyrosine phosphatase activity, hydrolase activity, protein binding, structural molecule activity) and to localize in various compartments (nucleus, cytoplasm, cytoskeleton). |
PTPL1: a large phosphatase with a split personality. |
Abaan OD, Toretsky JA. |
Cancer Metastasis Rev. 2008 Jun; 27(2): 205-214. (Review) |
PMID 18265946 |
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A novel protein-tyrosine phosphatase with homology to both the cytoskeletal proteins of the band 4.1 family and junction-associated guanylate kinases. |
Banville D, Ahmad S, Stocco R, Shen SH. |
J. Biol. Chem. 1994; 269: 22320-22327. |
PMID 8071359 |
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PTPN13, a Fas-associated protein tyrosine phosphatase, is located on the long arm of chromosome 4 at band q21.3. |
Inazawa J, Ariyama T, Abe T, Druck T, Ohta M, Huebner K, Yanagisawa J, Reed JC, Sato T. |
Genomics 1996; 31: 240-242. |
PMID 8824809 |
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Molecular cloning of a novel protein-tyrosine phosphatase containing a membrane-binding domain and GLGF repeats. |
Maekawa K, Imagawa N, Nagamatsu M, Harada S. |
FEBS Lett. 1994; 337: 200-206. |
PMID 8287977 |
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Cloning and characterization of PTPL1, a protein tyrosine phosphatase with similarities to cytoskeletal-associated proteins. |
Saras J, Claesson-Welsh L, Heldin CH, Gonez LJ. |
J. Biol. Chem. 1994; 269: 24082-24089. |
PMID 7929060 |
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Mutational analysis of the tyrosine phosphatome in colorectal cancers. |
Wang Z, Shen D, Parsons DW, Bardelli A, Sager J, Szabo S, Ptak J, Silliman N, Peters BA, van der Heijden MS, Parmigiani G, Yan H, Wang TL, Riggins G, Powell SM, Willson JKV, Markowitz S, Kinzler KW, Vogelstein B, Velculescu VE. |
Science 2004; 304: 1164-1166. |
PMID 15155950 |
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Genetic characterization of fas-associated phosphatase-1 as a putative tumor suppressor gene on chromosome 4q21.3 in hepatocellular carcinoma. |
Yeh SH, Wu DC, Tsai CY, Kuo TJ, Yu WC, Chang YS, Chen CL, Chang CF, Chen DS, Chen PJ. |
Clin Cancer Res. 2006 Feb 15; 12(4): 1097-1108. |
PMID 16489062 |
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Epigenetic disruption of two proapoptotic genes MAPK10/JNK3 and PTPN13/FAP-1 in multiple lymphomas and carcinomas through hypermethylation of a common bidirectional promoter. |
Ying J, Li H, Cui Y, Wong AH, Langford C, Tao Q. |
Leukemia. 2006 Jun; 20(6): 1173-1175. |
PMID 16572203 |
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Head-to-head juxtaposition of Fas-associated phosphatase-1 (FAP-1) and c-Jun NH2-terminal kinase 3 (JNK3) genes: genomic structure and seven polymorphisms of the FAP-1 gene. |
Yoshida S, Harada H, Nagai H, Fukino K, Teramoto A, Emi M. |
J. Hum. Genet. 2002; 47: 614-619. |
PMID 12436199 |
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The gene (PTPN13) encoding the protein tyrosine phosphatase PTP-BL/PTP-BAS is located in mouse chromosome region 5E/F and human chromosome region 4q21. |
van den Maagdenberg AM, Olde Weghuis D, Rijss J, Merkx GF, Wieringa B, Geurts van Kessel A, Hendriks WJ. |
Cytogenet. Cell Genet. 1996; 74: 153-155. |
PMID 8893825 |
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