RAP2A (RAP2A, member of RAS oncogene family)
2001-05-01 Jean de Gunzburg AffiliationLaboratoire de Signalisation Intracellulaire et Oncogenöse INSERM U-528 Institut Curie Section de Recherche 26, rue dUlm, 75248 Paris Cedex 05, France
Identity
HGNC
LOCATION
13q32.1
LOCUSID
ALIAS
K-REV,KREV,RAP2,RbBP-30
FUSION GENES
DNA/RNA
Description
The gene contains 2 coding exons separated by a large (29,418 bp) intron covering a total of 30,065 bp on chromosome 13
Proteins
Expression
ubiquitous ; higher in brain and hemopoIetic tissues
Localisation
plasma and/or intracellular membranes (endoplasmic reticulum)
Function
unknonw
Homology
90% identical to Rap2B, 60% identical to Rap1, 50 % to Ras proteins
Mutations
Germinal
unknown
Implicated in
Entity name
no implication in pathologies characterized so far
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 1923507 | 1991 | Post-translational processing and subcellular localization of the Ras-related Rap2 protein. | Béranger F et al |
| 9523700 | 1998 | Identification of a specific effector of the small GTP-binding protein Rap2. | Janoueix-Lerosey I et al |
| 1900290 | 1991 | The product of the rap2 gene, member of the ras superfamily. Biochemical characterization and site-directed mutagenesis. | Lerosey I et al |
| 10913189 | 2000 | Rap2 as a slowly responding molecular switch in the Rap1 signaling cascade. | Ohba Y et al |
| 3045729 | 1988 | Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region. | Pizon V et al |
Other Information
Locus ID:
NCBI: 5911
MIM: 179540
HGNC: 9861
Ensembl: ENSG00000125249
Variants:
dbSNP: 5911
ClinVar: 5911
TCGA: ENSG00000125249
COSMIC: RAP2A
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000125249 | ENST00000245304 | P10114 |
| ENSG00000125249 | ENST00000476869 | F6U784 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38574891 | 2024 | Interplay of RAP2 GTPase and the cytoskeleton in Hippo pathway regulation. | 0 |
| 38574891 | 2024 | Interplay of RAP2 GTPase and the cytoskeleton in Hippo pathway regulation. | 0 |
| 35054818 | 2022 | Simulated Microgravity Increases the Permeability of HUVEC Monolayer through Up-Regulation of Rap1GAP and Decreased Rap2 Activation. | 1 |
| 35293963 | 2022 | Ubiquitylation by Rab40b/Cul5 regulates Rap2 localization and activity during cell migration. | 8 |
| 35538031 | 2022 | TGF-β1-induced RAP2 regulates invasion in pancreatic cancer. | 3 |
| 35054818 | 2022 | Simulated Microgravity Increases the Permeability of HUVEC Monolayer through Up-Regulation of Rap1GAP and Decreased Rap2 Activation. | 1 |
| 35293963 | 2022 | Ubiquitylation by Rab40b/Cul5 regulates Rap2 localization and activity during cell migration. | 8 |
| 35538031 | 2022 | TGF-β1-induced RAP2 regulates invasion in pancreatic cancer. | 3 |
| 33313944 | 2021 | lncRNA FLVCR1‑AS1 drives colorectal cancer progression via modulation of the miR‑381/RAP2A axis. | 6 |
| 34018090 | 2021 | RAP2A promotes apoptosis resistance of hepatocellular carcinoma cells via the mTOR pathway. | 2 |
| 34090323 | 2021 | Tumor suppressive role of miR-33a-5p in pancreatic ductal adenocarcinoma cells by directly targeting RAP2A. | 6 |
| 33313944 | 2021 | lncRNA FLVCR1‑AS1 drives colorectal cancer progression via modulation of the miR‑381/RAP2A axis. | 6 |
| 34018090 | 2021 | RAP2A promotes apoptosis resistance of hepatocellular carcinoma cells via the mTOR pathway. | 2 |
| 34090323 | 2021 | Tumor suppressive role of miR-33a-5p in pancreatic ductal adenocarcinoma cells by directly targeting RAP2A. | 6 |
| 33015796 | 2020 | Abnormal expression of Rap2A as a prognostic marker for human breast cancer. | 0 |
Citation
Jean de Gunzburg
RAP2A (RAP2A, member of RAS oncogene family)
Atlas Genet Cytogenet Oncol Haematol. 2001-05-01
Online version: http://atlasgeneticsoncology.org/gene/274/rap2a
