RAP2A

Identity

HGNC	RAP2A
Location	13q34
Location_base_pair	Starts at 96884477 and ends at 96918245 bp from pter ( according to hg18-Mar_2006).

DNA/RNA

Description	The gene contains 2 coding exons separated by a large (29,418 bp) intron covering a total of 30,065 bp on chromosome 13

Protein

Description	Rap2 is a member of the Ras superfamily of monomeric GTPases, closely related to Ras. There are twoisoforms, RAP2A and Rap2B that share 90% identity and are encoded by two different genes. Rap2 proteinsshare 50% identity with Ras proteins, including the regions involved in GDP/GTP binding (hence Rap2A hasvery similar biochemical properties to Ras), C-terminal CAAX domain leading to prenylation (farnesylationfor Rap2A and geranylgeranylation in the case of Rap2B) and palmitoylation. The effector region of Rap2 isvery similar to that of Ras proteins, yet Ras and Rap2 do share seem to share effectors.
Expression	ubiquitous ; higher in brain and hemopoIetic tissues
Localisation	plasma and/or intracellular membranes (endoplasmic reticulum)
Function	unknonw
Homology	90% identical to Rap2B, 60% identical to Rap1, 50 % to Ras proteins

Mutations

Germinal

unknown

Implicated in

Entity	no implication in pathologies characterized so far

To be noted

see also RAP family

External links

	Nomenclature
HGNC	RAP2A   9861
Entrez_Gene	RAP2A  5911  RAP2A, member of RAS oncogene family
	Cards
Atlas	RAP2AID274
GeneCards	RAP2A
Ensembl	RAP2A [Search_View]   ENSG00000125249 [Gene_View]  RAP2A [Vega]
Genatlas	RAP2A
GeneLynx	RAP2A
eGenome	RAP2A
euGene	5911
	Genomic and cartography
GoldenPath	RAP2A  -  13q34   chr13:96884477-96918245 +  13q34   [Description]    (hg18-Mar_2006)
Ensembl	RAP2A - 13q34 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	RAP2A
	Gene and transcription
Genbank	AF205602 [ ENTREZ ]
Genbank	AF493914 [ ENTREZ ]
Genbank	AK090533 [ ENTREZ ]
Genbank	AK094586 [ ENTREZ ]
Genbank	AK315139 [ ENTREZ ]
RefSeq	NM_021033 [ SRS ]    NM_021033 [ ENTREZ ]
RefSeq	AC_000056 [ SRS ]    AC_000056 [ ENTREZ ]
RefSeq	AC_000145 [ SRS ]    AC_000145 [ ENTREZ ]
RefSeq	NC_000013 [ SRS ]    NC_000013 [ ENTREZ ]
RefSeq	NT_009952 [ SRS ]    NT_009952 [ ENTREZ ]
RefSeq	NW_001838084 [ SRS ]    NW_001838084 [ ENTREZ ]
RefSeq	NW_925517 [ SRS ]    NW_925517 [ ENTREZ ]
CCDS	RAP2A CCDS - NCBI
AceView	RAP2A AceView - NCBI
Unigene	Hs.508480 [ SRS ]    Hs.508480 [ NCBI ]     HS508480 [ spliceNest ]
Fast-db	7819 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P10114 [ SRS]    P10114 [ EXPASY ]     P10114 [ INTERPRO ]     P10114 [ UNIPROT ] P10114 [ VarSplice ]
Interpro	IPR003577 GTPase_Ras [ SRS ]    IPR003577 GTPase_Ras [ EBI ]
Interpro	IPR013753 Ras [ SRS ]    IPR013753 Ras [ EBI ]
Interpro	IPR001806 Ras_trnsfrmng [ SRS ]    IPR001806 Ras_trnsfrmng [ EBI ]
Interpro	IPR005225 Small_GTP_bd [ SRS ]    IPR005225 Small_GTP_bd [ EBI ]
CluSTr	P10114
Pfam	PF00071 Ras [ SRS ]    PF00071 Ras [ Sanger ]    pfam00071 [ NCBI-CDD ]
Smart	SM00173 RAS [EMBL]
Blocks	P10114
PDB	1KAO [ SRS ]    1KAO [ PdbSum ],   1KAO [ IMB ]   1KAO [ RSDB ]
PDB	2RAP [ SRS ]    2RAP [ PdbSum ],   2RAP [ IMB ]   2RAP [ RSDB ]
PDB	3RAP [ SRS ]    3RAP [ PdbSum ],   3RAP [ IMB ]   3RAP [ RSDB ]
HPRD	01547
	Protein Interaction databases
DIP	P10114
IntAct	P10114
	Polymorphism : SNP, mutations, diseases
OMIM	179540    [ map ]
GENECLINICS	179540
SNP	RAP2A [dbSNP-NCBI]
SNP	NM_021033 [SNP-NCI]
SNP	RAP2A [GeneSNPs - Utah]  RAP2A] [HGBASE - SRS]
HAPMAP	RAP2A [HAPMAP]
COSMIC	RAP2A [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	RAP2A
Genetic Association	RAP2A
CDC HuGE	RAP2A
	General knowledge
Family Browser	RAP2A [UCSC Family Browser]
SOURCE	NM_021033
SMD	Hs.508480
SAGE	Hs.508480
GO	nucleotide binding [Amigo]  nucleotide binding
GO	GTPase activity [Amigo]  GTPase activity
GO	GTP binding [Amigo]  GTP binding
GO	intracellular [Amigo]  intracellular
GO	plasma membrane [Amigo]  plasma membrane
GO	signal transduction [Amigo]  signal transduction
GO	small GTPase mediated signal transduction [Amigo]  small GTPase mediated signal transduction
PubGene	RAP2A
TreeFam	RAP2A
CTD	5911 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	RAP2A Related clones (RZPD - Berlin)
	PubMed
PubMed	29 Pubmed reference(s) in Entrez

Bibliography

Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region.

Pizon V, Chardin P, Lerosey I, Olofsson B, Tavitian A

Oncogene. 1988 ; 3 (2) : 201-204.

PMID 3045729

The product of the rap2 gene, member of the ras superfamily. Biochemical characterization and site-directed mutagenesis.

Lerosey I, Chardin P, de Gunzburg J, Tavitian A

The Journal of biological chemistry. 1991 ; 266 (7) : 4315-4321.

PMID 1900290

Post-translational processing and subcellular localization of the Ras-related Rap2 protein.

Bˆ©ranger F, Tavitian A, de Gunzburg J

Oncogene. 1991 ; 6 (10) : 1835-1842.

PMID 1923507

Identification of a specific effector of the small GTP-binding protein Rap2.

Janoueix-Lerosey I, Pasheva E, de Tand MF, Tavitian A, de Gunzburg J

European journal of biochemistry / FEBS. 1998 ; 252 (2) : 290-298.

PMID 9523700

Rap2 as a slowly responding molecular switch in the Rap1 signaling cascade.

Ohba Y, Mochizuki N, Matsuo K, Yamashita S, Nakaya M, Hashimoto Y, Hamaguchi M, Kurata T, Nagashima K, Matsuda M

Molecular and cellular biology. 2000 ; 20 (16) : 6074-6083.

PMID 10913189

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	05-2001	Jean de Gunzburg

Citation

This paper should be referenced as such :

Gunzburg J de . RAP2A. Atlas Genet Cytogenet Oncol Haematol. May 2001 . URL : http://AtlasGeneticsOncology.org/Genes/RAP2AID274.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sun Nov 9 19:46:32 2008