RAP2B (RAP2B, member of RAS oncogene family)
2001-05-01 Jean de Gunzburg AffiliationLaboratoire de Signalisation Intracellulaire et Oncogenöse INSERM U-528 Institut Curie Section de Recherche 26, rue dUlm, 75248 Paris Cedex 05, France
Identity
HGNC
LOCATION
3q25.2
IMAGE
LEGEND
Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
LOCUSID
ALIAS
-
FUSION GENES
DNA/RNA
Description
The gene contains 1 coding exon only covering 644 bp
Proteins
Expression
ubiquitous ; higher in brain and hemopoietic tissues (especially rich in platelets and meutrophils)
Localisation
plasma and/or intracellular membranes (endoplasmic reticulum)
Function
unknown
Homology
90% identical to Rap2A, 60% identical to Rap1, 50 % to Ras proteins
Mutations
Germinal
unknown
Implicated in
Entity name
no implication in pathologies characterized so far
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 10913189 | 2000 | Rap2 as a slowly responding molecular switch in the Rap1 signaling cascade. | Ohba Y et al |
Other Information
Locus ID:
NCBI: 5912
MIM: 179541
HGNC: 9862
Ensembl: ENSG00000181467
Variants:
dbSNP: 5912
ClinVar: 5912
TCGA: ENSG00000181467
COSMIC: RAP2B
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000181467 | ENST00000323534 | P61225 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Immune System | REACTOME | R-HSA-168256 |
| Innate Immune System | REACTOME | R-HSA-168249 |
| Neutrophil degranulation | REACTOME | R-HSA-6798695 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36958293 | 2023 | Hsa_circ_0008035 Knockdown Inhibits Bladder Cancer Progression through miR-1184/RAP2B Axis. | 0 |
| 36958293 | 2023 | Hsa_circ_0008035 Knockdown Inhibits Bladder Cancer Progression through miR-1184/RAP2B Axis. | 0 |
| 36444911 | 2022 | MicroRNA-708 suppresses the proliferation, migration, and invasion of human retinoblastoma cells by targeting RAP2B, a member of the RAS oncogene family. | 0 |
| 36444911 | 2022 | MicroRNA-708 suppresses the proliferation, migration, and invasion of human retinoblastoma cells by targeting RAP2B, a member of the RAS oncogene family. | 0 |
| 33023331 | 2021 | Long non-coding RNA CCAT1 promotes non-small cell lung cancer progression by regulating the miR-216a-5p/RAP2B axis. | 4 |
| 33023331 | 2021 | Long non-coding RNA CCAT1 promotes non-small cell lung cancer progression by regulating the miR-216a-5p/RAP2B axis. | 4 |
| 30763357 | 2019 | The cAMP effectors, Rap2b and EPAC, are involved in the regulation of the development of the Coxiella burnetii containing vacuole by altering the fusogenic capacity of the vacuole. | 5 |
| 30997639 | 2019 | Rap2B promotes cell adhesion, proliferation, migration and invasion of human glioma. | 5 |
| 30763357 | 2019 | The cAMP effectors, Rap2b and EPAC, are involved in the regulation of the development of the Coxiella burnetii containing vacuole by altering the fusogenic capacity of the vacuole. | 5 |
| 30997639 | 2019 | Rap2B promotes cell adhesion, proliferation, migration and invasion of human glioma. | 5 |
| 28390112 | 2018 | Knockdown of Rap2B, a Ras Superfamily Protein, Inhibits Proliferation, Migration, and Invasion in Cervical Cancer Cells via Regulating the ERK1/2 Signaling Pathway. | 10 |
| 28409547 | 2018 | Long Noncoding RNA XIST Promotes Osteosarcoma Progression by Targeting Ras-Related Protein RAP2B via miR-320b. | 36 |
| 28390112 | 2018 | Knockdown of Rap2B, a Ras Superfamily Protein, Inhibits Proliferation, Migration, and Invasion in Cervical Cancer Cells via Regulating the ERK1/2 Signaling Pathway. | 10 |
| 28409547 | 2018 | Long Noncoding RNA XIST Promotes Osteosarcoma Progression by Targeting Ras-Related Protein RAP2B via miR-320b. | 36 |
| 28081729 | 2017 | Knockdown of Rap2B Inhibits the Proliferation and Invasion in Hepatocellular Carcinoma Cells. | 12 |
Citation
Jean de Gunzburg
RAP2B (RAP2B, member of RAS oncogene family)
Atlas Genet Cytogenet Oncol Haematol. 2001-05-01
Online version: http://atlasgeneticsoncology.org/gene/275/rap2b
