RECQL5 (RecQ protein-like 5)
2002-04-01 Mounira Amor-Guéret AffiliationInstitut Curie - Section de Recherche, UMR 2027 CNRS, Bâtiment 110, Centre Universitaire, F-91405 Orsay Cedex, France
DNA/RNA
Transcription
Three different transcripts : 3715 bases (RecQ5a), 3703 bases (RecQ5b), 1749 bases (RecQ5g).
Proteins
Description
410 amino acids (RecQ5a), 991 amino acids (RecQ5b), 435 amino acids (RecQ5g). The predicted protein structures of all three polypeptides share seven motifs conserved for DNA helicases. RecQ5b contains a large C-terminal region that includes a domain homologous to the non-helicase domain of the E. coli RecQ DNA helicase.
Localisation
RecQ5a and RecQ5g are localized in the cytoplasm, whereas RecQ5b is localized in the nucleus.
Function
Unknown
Homology
Homologous to RecQ helicases, a subfamily of DExH box-containing DNA and RNA helicases. In particular, similarities with the four known human members in the RecQ subfamily, human RecQL, human RecQL4, human BLM, the product of the Bloom syndrome gene and human WRN, the product of the Werner syndrome gene.
Mutations
Note
Not described yet, and correlation with genetic disorder, if any, is unknown.
Implicated in
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 11032027 | 2000 | Differential regulation of human RecQ family helicases in cell transformation and cell cycle. | Kawabe T et al |
| 9878247 | 1998 | Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes. | Kitao S et al |
| 10710432 | 2000 | Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta. | Shimamoto A et al |
Other Information
Locus ID:
NCBI: 9400
MIM: 603781
HGNC: 9950
Ensembl: ENSG00000108469
Variants:
dbSNP: 9400
ClinVar: 9400
TCGA: ENSG00000108469
COSMIC: RECQL5
RNA/Proteins
Expression (GTEx)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38874681 | 2024 | RecQ helicase expression in patients with telomeropathies. | 0 |
| 38874681 | 2024 | RecQ helicase expression in patients with telomeropathies. | 0 |
| 34822842 | 2022 | The deubiquitinase USP28 stabilizes the expression of RecQ family helicases and maintains the viability of triple negative breast cancer cells. | 7 |
| 34822842 | 2022 | The deubiquitinase USP28 stabilizes the expression of RecQ family helicases and maintains the viability of triple negative breast cancer cells. | 7 |
| 33197722 | 2021 | RECQL5 KIX domain splicing isoforms have distinct functions in transcription repression and DNA damage response. | 2 |
| 33217443 | 2021 | Human RECQL5 promotes metastasis and resistance to cisplatin in non-small cell lung cancer. | 6 |
| 33332547 | 2021 | Single-molecule visualization of human RECQ5 interactions with single-stranded DNA recombination intermediates. | 8 |
| 33431668 | 2021 | ATRX and RECQ5 define distinct homologous recombination subpathways. | 18 |
| 33567180 | 2021 | Human RecQ helicases in transcription-associated stress management: bridging the gap between DNA and RNA metabolism. | 4 |
| 33197722 | 2021 | RECQL5 KIX domain splicing isoforms have distinct functions in transcription repression and DNA damage response. | 2 |
| 33217443 | 2021 | Human RECQL5 promotes metastasis and resistance to cisplatin in non-small cell lung cancer. | 6 |
| 33332547 | 2021 | Single-molecule visualization of human RECQ5 interactions with single-stranded DNA recombination intermediates. | 8 |
| 33431668 | 2021 | ATRX and RECQ5 define distinct homologous recombination subpathways. | 18 |
| 33567180 | 2021 | Human RecQ helicases in transcription-associated stress management: bridging the gap between DNA and RNA metabolism. | 4 |
| 32497619 | 2020 | Mining the role of RECQL5 in gastric cancer and seeking potential regulatory network by bioinformatics analysis. | 3 |
Citation
Mounira Amor-Guéret
RECQL5 (RecQ protein-like 5)
Atlas Genet Cytogenet Oncol Haematol. 2002-04-01
Online version: http://atlasgeneticsoncology.org/gene/286/recql5
