REG4 (regenerating gene type IV)

2003-08-01   Jean-Loup Huret , Sylvie Senon 

Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Identity

HGNC
REG4
LOCATION
1p12
LOCUSID
83998
ALIAS
GISP,REG-IV,RELP
FUSION GENES
Show Gene Fusions

DNA/RNA

Description

the gene spans 17 kb; 1191 bp cDNA; 6 exons; ORF: 474 bp

Proteins

Expression

gastrointestinal tract: stomach, small intestine, colon, and pancreas. High expression inCrohns disease and in ulcerative colitis.

Function

supposed to be involved in cell regeneration and/ or survival

Homology

with other members of the REG family, of which are PSP/REG-I alpha and PAP

Mutations

Somatic

strongly expressed in colorectal tumors as compared to normal colon tissue.

Implicated in

Bibliography

Pubmed IDLast YearTitleAuthors
113119422001Isolation and characterization of a cDNA encoding a novel member of the human regenerating protein family: Reg IV.Hartupee JC et al
124550322003Reg IV, a new member of the regenerating gene family, is overexpressed in colorectal carcinomas.Violette S et al

Other Information

Locus ID:

NCBI: 83998
MIM: 609846
HGNC: 22977
Ensembl: ENSG00000134193

Variants:

dbSNP: 83998
ClinVar: 83998
TCGA: ENSG00000134193
COSMIC: REG4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134193ENST00000256585Q9BYZ8
ENSG00000134193ENST00000256585A0A024R0M1
ENSG00000134193ENST00000354219Q9BYZ8
ENSG00000134193ENST00000354219A0A024R0M1
ENSG00000134193ENST00000369401Q9BYZ8
ENSG00000134193ENST00000530654E9PNV6

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
224308472012Coordinated expression of REG4 and aldehyde dehydrogenase 1 regulating tumourigenic capacity of diffuse-type gastric carcinoma-initiating cells is inhibited by TGF-β.35
164014772006Reg IV activates the epidermal growth factor receptor/Akt/AP-1 signaling pathway in colon adenocarcinomas.30
181879592007Serum concentration of Reg IV in patients with colorectal cancer: overexpression and high serum levels of Reg IV are associated with liver metastasis.28
235194542013REG gene expression in inflamed and healthy colon mucosa explored by in situ hybridisation.22
248863162014Tumor suppressor miR-24 restrains gastric cancer progression by downregulating RegIV.20
169189912006Novel tumor marker REG4 detected in serum of patients with resectable pancreatic cancer and feasibility for antibody therapy targeting REG4.18
191437682009Reg IV enhances peritoneal metastasis in gastric carcinomas.17
145509542003Overexpression of Reg IV in colorectal adenoma.14
187548682008Reg IV is an independent prognostic factor for relapse in patients with clinically localized prostate cancer.14
193299382009Expression profile of REG family proteins REG Ialpha and REG IV in advanced gastric cancer: comparison with mucin phenotype and prognostic markers.14

Citation

Jean-Loup Huret ; Sylvie Senon

REG4 (regenerating gene type IV)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/485/reg4