RHOH (Ras homolog gene family, member H)

1998-02-01   Sylvie Galiègue-Zouitina 

U.124 INSERM, I.R.C.L., Place de Verdun, 59045 LILLE Cedex, France

Identity

HGNC
RHOH
LOCATION
4p14
IMAGE
Atlas Image
LEGEND
RHPH (4p13) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics.
LOCUSID
399
ALIAS
ARHH,TTF
FUSION GENES
Show Gene Fusions

DNA/RNA

Description

spans on a 35 kb genomic fragment; two exons separated by a large intron; small GTPase encoding gene

Transcription

2.2 kb mRNA; coding sequence: 575 bp, located in the second exon

Proteins

Description

191 amino acids; 21 kDa; contains a GTP binding motif, a GTPase activity site, and a membrane localisation signal (CAAX box) in the very C-term

Expression

restricted to the hemopoietic tissues

Localisation

plasmic membrane

Function

small GTPase of the Rho subfamily; involved in signal transduction and cytoskeletal reorganization

Homology

with all GTPases of the Ras superfamily

Implicated in

Entity name
t(3;4)(q27;p13)/NHL --> BCL6 - RHOH
Disease
follicular NHL
Cytogenetics
observed as a secondary anomaly
Hybrid gene
5 RHOH - 3 BCL6 and 5 BCL6 - 3 RHOH, leading to two fusion transcripts
Fusion protein
no fusion protein, but promoter exchange between both partner genes
Entity name
t(4;14)(p13;q32)/multiple myeloma --> RHOH - ??
Disease
multiple myeloma
Prognosis
still unknown: only 1 available case
Cytogenetics
observed as a unique anomaly
Hybrid gene
not yet known (under study)

Breakpoints

Atlas Image

Bibliography

Pubmed IDLast YearTitleAuthors
77840611995TTF, a gene encoding a novel small G protein, fuses to the lymphoma-associated LAZ3 gene by t(3;4) chromosomal translocation.Dallery E et al
92263771997Genomic structure and assignment of the RhoH/TTF small GTPase gene (ARHH) to 4p13 by in situ hybridization.Dallery-Prudhomme E et al

Other Information

Locus ID:

NCBI: 399
MIM: 602037
HGNC: 686
Ensembl: ENSG00000168421

Variants:

dbSNP: 399
ClinVar: 399
TCGA: ENSG00000168421
COSMIC: RHOH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168421ENST00000381799Q15669
ENSG00000168421ENST00000381799Q6ICP4
ENSG00000168421ENST00000503941D6RG23
ENSG00000168421ENST00000505618Q15669
ENSG00000168421ENST00000505618Q6ICP4
ENSG00000168421ENST00000507851D6RA52
ENSG00000168421ENST00000508513D6R8Z1
ENSG00000168421ENST00000610353Q15669
ENSG00000168421ENST00000610353Q6ICP4
ENSG00000168421ENST00000613272Q15669
ENSG00000168421ENST00000613272Q6ICP4
ENSG00000168421ENST00000614836Q15669
ENSG00000168421ENST00000614836Q6ICP4
ENSG00000168421ENST00000615083Q15669
ENSG00000168421ENST00000615083Q6ICP4
ENSG00000168421ENST00000615577Q15669
ENSG00000168421ENST00000615577Q6ICP4
ENSG00000168421ENST00000617441Q15669
ENSG00000168421ENST00000617441Q6ICP4
ENSG00000168421ENST00000619474Q15669
ENSG00000168421ENST00000619474Q6ICP4
ENSG00000168421ENST00000622175Q15669
ENSG00000168421ENST00000622175Q6ICP4

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Leukocyte transendothelial migrationKEGGko04670
Leukocyte transendothelial migrationKEGGhsa04670
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
228508762012Human RHOH deficiency causes T cell defects and susceptibility to EV-HPV infections.29
238508282013Hematopoietic-specific Rho GTPases Rac2 and RhoH and human blood disorders.25
224742512012RhoH is critical for cell-microenvironment interactions in chronic lymphocytic leukemia in mice and humans.16
198471972010Involvement of RhoH GTPase in the development of B-cell chronic lymphocytic leukemia.15
208517662011RhoH modulates pre-TCR and TCR signalling by regulating LCK.13
165411392006Richter's and prolymphocytic transformation of chronic lymphocytic leukemia are associated with high mRNA expression of activation-induced cytidine deaminase and aberrant somatic hypermutation.11
226899942012Opposing roles for RhoH GTPase during T-cell migration and activation.10
174432192007Prognostic analysis of aberrant somatic hypermutation of RhoH gene in diffuse large B cell lymphoma.9
186912532008Prognostic implication and biological roles of RhoH in acute myeloid leukaemia.9

Citation

Sylvie Galiègue-Zouitina

RHOH (Ras homolog gene family, member H)

Atlas Genet Cytogenet Oncol Haematol. 1998-02-01

Online version: http://atlasgeneticsoncology.org/gene/93/rhoh