| Entity | Lung cancer |
| Oncogenesis | A deletion of chromosome 3 allele and dysfunction or lack of ROBO1 receptors might be an early somatic genetic change in lung tumor development (Xian et al., 2001; Dallol et al., 2002b; Tsujiuchi et al., 2004; Xian et al., 2004). |
| | |
| Entity | Breast cancer |
| Oncogenesis | Breast cancer tumors and tumor cell lines show a suppressed expression of ROBO1 gene (Dallol et al., 2002a; Dallol et al., 2002b). |
| | |
| Entity | Prostate cancer |
| Oncogenesis | Human prostate tumors and tumor cell lines show an overexpression of ROBO1 gene (Bonner et al., 2003). |
| | |
| Entity | Angiogenesis of malignant tumors |
| Oncogenesis | ROBO1 gene is highly expressed in tumor vessel endothelium. Blocking of ROBO1 receptors causes loss of microvessel density in tumors e.g. malignant melanoma, colorectal cancer (Wang et al., 2003; Suchting et al., 2005; Groene et al., 2006; Legg et al., 2008). |
| | |
| Entity | Colorectal cancer |
| Oncogenesis | ROBO1 gene is overexpressed in human colorectal cancer tumor probes and colorectal cancer cell lines (Groene et al., 2006). |
| | |
| Entity | Cervical cancer |
| Oncogenesis | Cervical Cancer exhibits highly complex genomic alterations. These include hemizygous deletions at 4p15.3, 10q24, 5q35, 3p12.3, and 11q24, the chromosomal sites of SLIT-ROBO pathway genes (Narayan et al., 2006). |
| | |
| Entity | Hepatocellular carcinoma |
| Oncogenesis | ROBO1, a member of the immunoglobulin superfamily, is highly expressed in hepatocellular carcinoma, whereas it showes only a limited distribution in normal liver tissue. Strikingly, the ectodomain of ROBO1 was detected not only in the culture medium of liver cancer cell lines (PLC/PRF/5, HepG2, etc.) but also in sera from hepatocellular carcinoma patients (Ito et al., 2006). |
| | |
| Entity | T-acute lymphoblastic leukaemia |
| Oncogenesis | ROBO1 gene alterations were detected in subpopulations with childhood T-acute lymphoblastic leukaemia (Haltrich et al., 2007). |
| | |
| Entity | Nasopharyngeal carcinoma |
| Oncogenesis | In an inducible Epstein-Barr virus (EBV) nasopharyngeal cell line was a increased expression of ROBO1 detected that may be cause a role in this tumor carcinogenesis (Lee et al., 2008). |
| | |
| Entity | Dyslexia |
| Disease | Dyslexia may be caused by partial haplo-insufficiency for ROBO1 in rare families. A slight disturbance in neuronal axon crossing across the midline between brain hemispheres, dendrite guidance, or another function of ROBO1 may manifest as a specific reading disability in humans (Hannula-Jouppi et al., 2005; Fisher and Francks, 2006; McGrath et al., 2006; Shastry, 2007; Paracchini et al., 2007). |
| | |
| Entity | Autism |
| Disease | Gene expression analysis show a reduced expression for ROBO1 in the autistic patient group and may play a role in pathogenesis of autism (Anitha et al., 2008). |
| | |
| Inadequate lung development and bronchial hyperplasia in mice with a targeted deletion in the Dutt1/Robo1 gene. |
| Xian J, Clark KJ, Fordham R, Pannell R, Rabbitts TH, Rabbitts PH. |
| Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15062-6. Epub 2001 Dec 4. |
| PMID 11734623 |
| |
| SLIT2, a human homologue of the Drosophila Slit2 gene, has tumor suppressor activity and is frequently inactivated in lung and breast cancers. |
| Dallol A, Da Silva NF, Viacava P, Minna JD, Bieche I, Maher ER, Latif F. |
| Cancer Res. 2002a Oct 15;62(20):5874-80. |
| PMID 12384551 |
| |
| Tumour specific promoter region methylation of the human homologue of the Drosophila Roundabout gene DUTT1 (ROBO1) in human cancers. |
| Dallol A, Forgacs E, Martinez A, Sekido Y, Walker R, Kishida T, Rabbitts P, Maher ER, Minna JD, Latif F. |
| Oncogene. 2002b May 2;21(19):3020-8. |
| PMID 12082532 |
| |
| Gene expression signatures identify novel regulatory pathways during murine lung development: implications for lung tumorigenesis. |
| Bonner AE, Lemon WJ, You M. |
| J Med Genet. 2003 Jun;40(6):408-17. |
| PMID 12807961 |
| |
| Quantification of expression of netrins, slits and their receptors in human prostate tumors. |
| Latil A, Chene L, Cochant-Priollet B, Mangin P, Fournier G, Berthon P, Cussenot O. |
| Int J Cancer. 2003 Jan 20;103(3):306-15. |
| PMID 12471613 |
| |
| Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity. |
| Wang B, Xiao Y, Ding BB, Zhang N, Yuan X, Gui L, Qian KX, Duan S, Chen Z, Rao Y, Geng JG. |
| Cancer Cell. 2003 Jul;4(1):19-29. |
| PMID 12892710 |
| |
| Alterations of the Dutt1/Robo1 gene in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats. |
| Tsujiuchi T, Sasaki Y, Oka Y, Kuniyasu H, Tsutsumi M. |
| Mol Carcinog. 2004 Aug;40(4):241-6. |
| PMID 15264215 |
| |
| Targeted disruption of the 3p12 gene, Dutt1/Robo1, predisposes mice to lung adenocarcinomas and lymphomas with methylation of the gene promoter. |
| Xian J, Aitchison A, Bobrow L, Corbett G, Pannell R, Rabbitts T, Rabbitts P. |
| Cancer Res. 2004 Sep 15;64(18):6432-7. |
| PMID 15374951 |
| |
| The axon guidance receptor gene ROBO1 is a candidate gene for developmental dyslexia. |
| Hannula-Jouppi K, Kaminen-Ahola N, Taipale M, Eklund R, Nopola-Hemmi J, Kaariainen H, Kere J. |
| PLoS Genet. 2005 Oct;1(4):e50. Epub 2005 Oct 28. |
| PMID 16254601 |
| |
| Soluble Robo4 receptor inhibits in vivo angiogenesis and endothelial cell migration. |
| Suchting S, Heal P, Tahtis K, Stewart LM, Bicknell R. |
| FASEB J. 2005 Jan;19(1):121-3. Epub 2004 Oct 14. |
| PMID 15486058 |
| |
| Genes, cognition and dyslexia: learning to read the genome. |
| Fisher SE, Francks C. |
| Trends Cogn Sci. 2006 Jun;10(6):250-7. Epub 2006 May 3. Review |
| PMID 16675285 |
| |
| Robo1/Robo4: differential expression of angiogenic markers in colorectal cancer. |
| Groene J, Doebler O, Loddenkemper C, Hotz B, Buhr HJ, Bhargava S. |
| Oncol Rep. 2006 Jun;15(6):1437-43. |
| PMID 16685377 |
| |
| Identification of ROBO1 as a novel hepatocellular carcinoma antigen and a potential therapeutic and diagnostic target. |
| Ito H, Funahashi S, Yamauchi N, Shibahara J, Midorikawa Y, Kawai S, Kinoshita Y, Watanabe A, Hippo Y, Ohtomo T, Iwanari H, Nakajima A, Makuuchi M, Fukayama M, Hirata Y, Hamakubo T, Kodama T, Tsuchiya M, Aburatani H. |
| Clin Cancer Res. 2006 Jun 1;12(11 Pt 1):3257-64. |
| PMID 16740745 |
| |
| Breakthroughs in the search for dyslexia candidate genes. |
| McGrath LM, Smith SD, Pennington BF. |
| Trends Mol Med. 2006 Jul;12(7):333-41. Epub 2006 Jun 16. Review |
| PMID 16781891 |
| |
| Promoter hypermethylation-mediated inactivation of multiple Slit-Robo pathway genes in cervical cancer progression. |
| Narayan G, Goparaju C, Arias-Pulido H, Kaufmann AM, Schneider A, Durst M, Mansukhani M, Pothuri B, Murty VV. |
| Mol Cancer. 2006 May 15;5:16. |
| PMID 16700909 |
| |
| [Genetics of dyslexia] |
| Schulte-Korne G, Warnke A, Remschmidt H. |
| Z Kinder Jugendpsychiatr Psychother. 2006 Nov;34(6):435-44. Review |
| PMID 17094062 |
| |
| Multipoint interphase FISH in childhood T-acute lymphoblastic leukemia detects subpopulations that carry different chromosome 3 aberrations. |
| Haltrich I, Kost-Alimova M, Kovacs G, Dobos M, Klein G, Fekete G, Imreh S. |
| Cancer Genet Cytogenet. 2007 Jan 1;172(1):54-60. |
| PMID 17175380 |
| |
| Production of Slit2 LRR domains in mammalian cells for structural studies and the structure of human Slit2 domain 3. |
| Morlot C, Hemrika W, Romijn RA, Gros P, Cusack S, McCarthy AA. |
| Acta Crystallogr D Biol Crystallogr. 2007 Sep;63(Pt 9):961-8. Epub 2007 Aug 17. |
| PMID 17704564 |
| |
| The genetic lexicon of dyslexia. |
| Paracchini S, Scerri T, Monaco AP. |
| Annu Rev Genomics Hum Genet. 2007;8:57-79. Review |
| PMID 17444811 |
| |
| Developmental dyslexia: an update. |
| Shastry BS. |
| J Hum Genet. 2007;52(2):104-9. Epub 2006 Nov 17. Review |
| PMID 17111266 |
| |
| Genetic analyses of roundabout (ROBO) axon guidance receptors in autism. |
| Anitha A, Nakamura K, Yamada K, Suda S, Thanseem I, Tsujii M, Iwayama Y, Hattori E, Toyota T, Miyachi T, Iwata Y, Suzuki K, Matsuzaki H, Kawai M, Sekine Y, Tsuchiya K, Sugihara G, Ouchi Y, Sugiyama T, Koizumi K, Higashida H, Takei N, Yoshikawa T, Mori N. |
| Am J Med Genet B Neuropsychiatr Genet. 2008 Oct 5;147B(7):1019-27. |
| PMID 18270976 |
| |
| Amplicons on chromosome 3 contain oncogenes induced by recurrent exposure to 12-O-tetradecanoylphorbol-13-acetate and sodium n-butyrate and Epstein-Barr virus reactivation in a nasopharyngeal carcinoma cell line. |
| Lee CH, Fang CY, Sheu JJ, Chang Y, Takada K, Chen JY. |
| Cancer Genet Cytogenet. 2008 Aug;185(1):1-10. |
| PMID 18656687 |
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| Slits and Roundabouts in cancer, tumour angiogenesis and endothelial cell migration. |
| Legg JA, Herbert JM, Clissold P, Bicknell R. |
| Angiogenesis. 2008;11(1):13-21. Epub 2008 Feb 9. Review |
| PMID 18264786 |
| |
| Targeting Slit-Roundabout signaling inhibits tumor angiogenesis in chemical-induced squamous cell carcinogenesis. |
| Wang LJ, Zhao Y, Han B, Ma YG, Zhang J, Yang DM, Mao JW, Tang FT, Li WD, Yang Y, Wang R, Geng JG. |
| Cancer Sci. 2008 Mar;99(3):510-7. Epub 2008 Jan 14. |
| PMID 18201275 |
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