| Nomenclature | | HGNC (Hugo) | SDHB 10681 |
| Entrez_Gene (NCBI) | SDHB 6390 succinate dehydrogenase complex, subunit B, iron sulfur (Ip) |
| Cards |
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| Atlas | SDHBID388 |
| GeneCards (Weizmann) | SDHB |
| Ensembl (Hinxton) | ENSG00000117118 [Gene_View] SDHB [Vega] |
| AceView (NCBI) | SDHB |
| Genatlas (Paris) | SDHB |
| euGene (Indiana) | 6390 |
| SOURCE (Stanford) | NM_003000
|
| Genomic and cartography |
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| GoldenPath (UCSC) | SDHB - chr1:17217812-17253252 - 1p36.1-p35 [Description] (hg18-Mar_2006) |
| Ensembl | SDHB - 1p36.1-p35 [CytoView] |
| Mapping of homologs : NCBI | SDHB [Mapview] |
| OMIM | 115310 171300 185470 606864 612359 |
| Gene and transcription |
| Gene : Genbank (Entrez) | AK312056 BC007840 BF796275 BU554163 CR593493 |
| Reference sequence (RefSeq transcript) :SRS | NM_003000 |
| Reference transcript : Entrez | NM_003000 |
| RefSeq genomic : SRS | AC_000044 AC_000133 NC_000001 NT_004610 NW_001838572 NW_927841 |
| RefSeq genomic : Entrez | AC_000044 AC_000133 NC_000001 NT_004610 NW_001838572 NW_927841 |
| Consensus coding sequences : CCDS NCBI | SDHB |
| Cluster EST : Unigene | Hs.465924 [ SRS ] Hs.465924 [ NCBI ] |
| Alternative Splicing : Fast-db (Paris) | 7840 |
| Protein : pattern, domain, 3D structure |
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| Protein : UniProt/SwissProt | P21912 (SRS) P21912 (Expasy) P21912 (Uniprot) |
| With graphics : InterPro | P21912 |
| Splice isoforms : VarSplice FASTA | P21912(VarSplice FASTA) |
| Domaine pattern : Prosite (SRS) | 2FE2S_FER_1 (PS00197) 2FE2S_FER_2 (PS51085) 4FE4S_FER_1 (PS00198) 4FE4S_FER_2 (PS51379) |
| Domain pattern : Prosite (Expaxy) | 2FE2S_FER_1 (PS00197) 2FE2S_FER_2 (PS51085) 4FE4S_FER_1 (PS00198) 4FE4S_FER_2 (PS51379) |
| Domains : Interpro (SRS) | 2Fe2S_fd_BS 4Fe4S_Fe_S_bd b-grasp_ferredoxin-like Ferredoxin Fum_reductase_C Succ_DHase/fum_Rdtase_Fe-S |
| Domains : Interpro (EBI) | 2Fe2S_fd_BS 4Fe4S_Fe_S_bd b-grasp_ferredoxin-like Ferredoxin Fum_reductase_C Succ_DHase/fum_Rdtase_Fe-S |
| Related proteins : CluSTr | P21912 |
| Domain families : Pfam SRS | Fer2 (PF00111) |
| Domain families : Pfam Sanger | Fer2 (PF00111) |
| Domain families : Pfam NCBI | pfam00111 |
| Blocks (Seattle) | P21912 |
| Crystal structure of protein : PDB SRS | |
| Crystal structure of protein : PDBSum | |
| Crystal structure of protein : IMB | |
| Crystal structure of protein : PDB RSDB | |
| HPRD | 01707 |
| Protein Interaction databases |
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| DIP (DOE-UCLA) | P21912 |
| IntAct (EBI) | P21912 |
| Polymorphism : SNP, mutations, diseases |
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| Single Nucleotide Polymorphism (SNP) : dbSNP NCBI | SDHB |
| SNP : GeneSNP Utah | SDHB |
| SNP : HGBase | SDHB |
| Genetic variants : HAPMAP | SDHB |
| Somatic Mutations in Cancer : COSMIC | SDHB |
| Mutations and Diseases : HGMD | SDHB |
| Hereditary diseases : OMIM | 115310 171300 185470 606864 612359 |
| Hereditary diseases : GENETests | 115310 171300 185470 606864 612359 |
| Diseases : Genetic Association | SDHB |
| General knowledge |
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| Homologs : HomoloGene | SDHB |
| Homology/Alignments : Family Browser UCSC | SDHB |
| Phylogenetic Trees/Animal Genes : TreeFam | SDHB |
| Catalytic activity : Enzyme | 1.3.5.1 [ Enzyme-Expasy ] 1.3.5.1 [ Enzyme-SRS ] 1.3.5.1 [ IntEnz-EBI ] 1.3.5.1 [ BRENDA ] 1.3.5.1 [ KEGG ] |
| Chemical/Protein Interactions : CTD | 6390 |
| Keywords Ontology : AmiGO | iron ion binding protein binding mitochondrion mitochondrial inner membrane mitochondrial inner membrane tricarboxylic acid cycle transport succinate dehydrogenase (ubiquinone) activity electron carrier activity membrane oxidoreductase activity electron transport chain metal ion binding 2 iron, 2 sulfur cluster binding 3 iron, 4 sulfur cluster binding 4 iron, 4 sulfur cluster binding |
| Keywords Ontology : EGO-EBI | iron ion binding protein binding mitochondrion mitochondrial inner membrane mitochondrial inner membrane tricarboxylic acid cycle transport succinate dehydrogenase (ubiquinone) activity electron carrier activity membrane oxidoreductase activity electron transport chain metal ion binding 2 iron, 2 sulfur cluster binding 3 iron, 4 sulfur cluster binding 4 iron, 4 sulfur cluster binding |
| Pathways : BIOCARTA | |
| Pathways : KEGG | Citrate cycle (TCA cycle)Oxidative phosphorylation |
| Other databases |
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| Probes |
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| Probes : Imagenes | SDHB Related clones (RZPD - Berlin) |
| Literature |
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| PubMed | 50 Pubmed reference(s) in Entrez |
| PubGene | SDHB |
| RASSF1A is part of a complex similar to the Drosophila Hippo/Salvador/Lats tumor-suppressor network. |
| Guo C, Tommasi S, Liu L, Yee JK, Dammann R, Pfeifer GP |
| Current biology : CB. 2007 ; 17 (8) : 700-705. |
| PMID 17379520 |
| |
| The gene for the iron sulfur protein of succinate dehydrogenase (SDH-IP) maps to human chromosome 1p35-36.1. |
| Leckschat S, Ream-Robinson D, Scheffler IE |
| Somatic cell and molecular genetics. 1993 ; 19 (5) : 505-511. |
| PMID 8291026 |
| |
| Structural organization of the gene encoding the human iron-sulfur subunit of succinate dehydrogenase. |
| Au HC, Ream-Robinson D, Bellew LA, Broomfield PL, Saghbini M, Scheffler IE |
| Gene. 1995 ; 159 (2) : 249-253. |
| PMID 7622059 |
| |
| Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma. |
| Astuti D, Latif F, Dallol A, Dahia PL, Douglas F, George E, Skˆldberg F, Husebye ES, Eng C, Maher ER |
| American journal of human genetics. 2001 ; 69 (1) : 49-54. |
| PMID 11404820 |
| |
| Prevalence of SDHB, SDHC, and SDHD germline mutations in clinic patients with head and neck paragangliomas. |
| Baysal BE, Willett-Brozick JE, Lawrence EC, Drovdlic CM, Savul SA, McLeod DR, Yee HA, Brackmann DE, Slattery WH 3rd, Myers EN, Ferrell RE, Rubinstein WS |
| Journal of medical genetics. 2002 ; 39 (3) : 178-183. |
| PMID 11897817 |
| |