SPI1 (spleen focus forming virus (SFFV) proviral integration oncogene spi1)
2000-11-01 Françoise Moreau-Gachelin AffiliationINSERM U528, Laboratoire de Transduction du Signal et Oncogenöse, Section de Recherche -Institut Curie, 26, rue dUlm, 75 248 Paris cedex 05, France
Identity
HGNC
LOCATION
11p11.2
LOCUSID
ALIAS
OF,PU.1,SFPI1,SPI-1,SPI-A
FUSION GENES
DNA/RNA
Description
genomic locus around 50kb; 5 exons
Transcription
1,4kb. open reading frame (ORF): 991bp
Proteins
Description
264 amino acids. DNA binding protein with a ETS consensus motif
Expression
hematopoietic specific; mainly in B lymphocytes and myeloid lineages; faintly expressed in erythroid progenitors
Localisation
nuclear
Function
transcriptional regulator; specific DNA binding sites with a G/AGAA minimal element in promoter and enhancers of myeloid and B lymphoid genes; involved both in transcriptional regulation of genes and in splicing regulation of pre-mRNAs
Homology
ETS genes family
Mutations
Germinal
unknown
Somatic
unknown in human pathologies and cancers; insertional mutagenesis in murine erythroleukemia
Implicated in
Entity name
Oncogenesis in mouse; mouse gene name: Spi-1 (SFFV Proviral Integration 1)
Disease
murine acute erythroleukemia induced by the Friend retrovirus SFFV (Spleen Focus Forming Virus)
Prognosis
100%
Hybrid gene
no
Fusion protein
No; overexpression of the normal protein in the proerythroblast
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 9478924 | 1998 | The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLS. | Hallier M et al |
| 2180582 | 1990 | The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene. | Klemsz MJ et al |
| 8896458 | 1996 | Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. | McKercher SR et al |
| 8628313 | 1996 | Spi-1/PU.1 transgenic mice develop multistep erythroleukemias. | Moreau-Gachelin F et al |
| 9133423 | 1997 | PU.1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors. | Scott EW et al |
Other Information
Locus ID:
NCBI: 6688
MIM: 165170
HGNC: 11241
Ensembl: ENSG00000066336
Variants:
dbSNP: 6688
ClinVar: 6688
TCGA: ENSG00000066336
COSMIC: SPI1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000066336 | ENST00000227163 | P17947 |
| ENSG00000066336 | ENST00000378538 | P17947 |
| ENSG00000066336 | ENST00000533030 | F5GZ94 |
| ENSG00000066336 | ENST00000533968 | F5H3K6 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37966708 | 2024 | Role of LINC00240 on T-helper 9 differentiation in allergic rhinitis through influencing DNMT1-dependent methylation of PU.1. | 0 |
| 38078733 | 2024 | Transcriptional regulation of the HIV-1 inhibitory factor human mannose receptor 1 by the myeloid-specific transcription factor PU.1. | 0 |
| 38951492 | 2024 | HIV-1 Vpr combats the PU.1-driven antiviral response in primary human macrophages. | 0 |
| 37966708 | 2024 | Role of LINC00240 on T-helper 9 differentiation in allergic rhinitis through influencing DNMT1-dependent methylation of PU.1. | 0 |
| 38078733 | 2024 | Transcriptional regulation of the HIV-1 inhibitory factor human mannose receptor 1 by the myeloid-specific transcription factor PU.1. | 0 |
| 38951492 | 2024 | HIV-1 Vpr combats the PU.1-driven antiviral response in primary human macrophages. | 0 |
| 36648591 | 2023 | PU.1 negatively regulates tumorigenesis in non-small-cell lung cancer. | 0 |
| 36688997 | 2023 | LINC01004-SPI1 axis-activated SIGLEC9 in tumor-associated macrophages induces radioresistance and the formation of immunosuppressive tumor microenvironment in esophageal squamous cell carcinoma. | 6 |
| 36967718 | 2023 | SPI1 Mediates N-Myristoyltransferase 1 to Advance Gastric Cancer Progression via PI3K/AKT/mTOR Pathway. | 2 |
| 37012859 | 2023 | SPI1-mediated autophagy of peripheral blood monocyte cells as a mechanism for sepsis based on single-cell RNA sequencing. | 3 |
| 37277671 | 2023 | SPI1 Regulates the Progression of Ankylosing Spondylitis by Modulating TLR5 via NF-κB Signaling. | 2 |
| 36648591 | 2023 | PU.1 negatively regulates tumorigenesis in non-small-cell lung cancer. | 0 |
| 36688997 | 2023 | LINC01004-SPI1 axis-activated SIGLEC9 in tumor-associated macrophages induces radioresistance and the formation of immunosuppressive tumor microenvironment in esophageal squamous cell carcinoma. | 6 |
| 36967718 | 2023 | SPI1 Mediates N-Myristoyltransferase 1 to Advance Gastric Cancer Progression via PI3K/AKT/mTOR Pathway. | 2 |
| 37012859 | 2023 | SPI1-mediated autophagy of peripheral blood monocyte cells as a mechanism for sepsis based on single-cell RNA sequencing. | 3 |
Citation
Françoise Moreau-Gachelin
SPI1 (spleen focus forming virus (SFFV) proviral integration oncogene spi1)
Atlas Genet Cytogenet Oncol Haematol. 2000-11-01
Online version: http://atlasgeneticsoncology.org/gene/269/spi1
