MMP11 (matrix metalloproteinase 11 (stromelysin 3))

2000-03-01   Paul Basset , Marie-Christine Rio 

Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS\\\/INSERM U184\\\/ULP BP 163, Illkirch, CU de Strasbourg, France

Identity

HGNC
LOCATION
22q11.23
LOCUSID
ALIAS
SL-3,ST3,STMY3
FUSION GENES

DNA/RNA

Description

8 exons and 7 introns spanning 11.5 kb; cDNA: 2247 bp, coding sequence 1464 bp

Transcription

expression is induced by retinoic acid and TPA through a DR1-type responsive element and a C/EBP binding site, respectively, expression is induced by epithelial cells in a paracrin manner

Proteins

Description

488 amino-acids; 51 kDa; functional domains: signal peptide, targeting the protein to the secretory pathway, prodomain containing a furin-type cleavage site responsible for the intracellular activation, catalytic domain containing a zinc binding site, hemopexin-like domain

Expression

cells of mesenchymal origin, notably fibroblastic cells, macrophages, osteoclasts

Function

extracellular zinc-dependent proteinase expressed during tissu remodelling processes (development, wound healing) and whose specific substrate is unknown

Homology

member of the matrix metalloproteinases (MMP) subfamily of matrixins

Implicated in

Entity name
various cancer:
Disease
expression of ST3 in 80 to 100% invasive carcinomas of the breast, colon, head and neck, lung, ovary, pancreas, prostate, skin (basal cell carcinoma), uterus (cervix carcinoma and endometrial carcinoma) and in some non-invasive carcinomas that have a high risk of evolving towards invasion; also expression in: fibroblastic stromal cells in the close vicinity of cancerous epithelial cells
Prognosis
prognostic factor of invasion and aggressiveness of the tumors

Bibliography

Pubmed IDLast YearTitleAuthors
95024141998Stromelysin 3: an independent prognostic factor for relapse-free survival in node-positive breast cancer and demonstration of novel breast carcinoma cell expression.Ahmad A et al
76576061995Structure and promoter characterization of the human stromelysin-3 gene.Anglard P et al
17018511990A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas.Basset P et al
89802451996High levels of stromelysin-3 correlate with poor prognosis in patients with breast carcinoma.Chenard MP et al
94171241998Stromelysin-3 is induced in tumor/stroma cocultures and inactivated via a tumor-specific and basic fibroblast growth factor-dependent mechanism.Mari BP et al
95087841998In vivo evidence that the stromelysin-3 metalloproteinase contributes in a paracrine manner to epithelial cell malignancy.Masson R et al
76575191994Stromelysin-3 gene expression in human cancer: an overview.Rouyer N et al

Other Information

Locus ID:

NCBI: 4320
MIM: 185261
HGNC: 7157
Ensembl: ENSG00000099953

Variants:

dbSNP: 4320
ClinVar: 4320
TCGA: ENSG00000099953
COSMIC: MMP11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000099953ENST00000215743P24347
ENSG00000099953ENST00000428253F8WDI7
ENSG00000099953ENST00000434318H7C3I7
ENSG00000099953ENST00000437086E9PED7

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Extracellular matrix organizationREACTOMER-HSA-1474244
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Activation of Matrix MetalloproteinasesREACTOMER-HSA-1592389
Collagen degradationREACTOMER-HSA-1442490

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
227682492012Ectopic expression of MiR-125a inhibits the proliferation and metastasis of hepatocellular carcinoma by targeting MMP11 and VEGF.67
232114912012MicroRNA miR-98 inhibits tumor angiogenesis and invasion by targeting activin receptor-like kinase-4 and matrix metalloproteinase-11.64
125384532003Hepatocyte growth factor receptor, matrix metalloproteinase-11, tissue inhibitor of metalloproteinase-1, and fibronectin are up-regulated in papillary thyroid carcinoma: a cDNA and tissue microarray study.40
206738682010A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).36
186224252008Matrix metalloproteinase-11/stromelysin-3 exhibits collagenolytic function against collagen VI under normal and malignant conditions.32
159896932005Overexpression of cathepsin F, matrix metalloproteinases 11 and 12 in cervical cancer.30
204524822010Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes.26
179804492008Expression of matrix metalloproteinases MMP-1, MMP-11 and MMP-19 is correlated with the WHO-grading of human malignant gliomas.22
182088022008Role of immunohistochemical overexpression of matrix metalloproteinases MMP-2 and MMP-11 in the prognosis of death by ovarian cancer.22

Citation

Paul Basset ; Marie-Christine Rio

MMP11 (matrix metalloproteinase 11 (stromelysin 3))

Atlas Genet Cytogenet Oncol Haematol. 2000-03-01

Online version: http://atlasgeneticsoncology.org/gene/200/mmp11