MMP11 (matrix metalloproteinase 11 (stromelysin 3))
2000-03-01 Paul Basset , Marie-Christine Rio AffiliationInstitut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS\\\/INSERM U184\\\/ULP BP 163, Illkirch, CU de Strasbourg, France
Identity
HGNC
LOCATION
22q11.23
LOCUSID
ALIAS
SL-3,ST3,STMY3
FUSION GENES
DNA/RNA
Description
8 exons and 7 introns spanning 11.5 kb; cDNA: 2247 bp, coding sequence 1464 bp
Transcription
expression is induced by retinoic acid and TPA through a DR1-type responsive element and a C/EBP binding site, respectively, expression is induced by epithelial cells in a paracrin manner
Proteins
Description
488 amino-acids; 51 kDa; functional domains: signal peptide, targeting the protein to the secretory pathway, prodomain containing a furin-type cleavage site responsible for the intracellular activation, catalytic domain containing a zinc binding site, hemopexin-like domain
Expression
cells of mesenchymal origin, notably fibroblastic cells, macrophages, osteoclasts
Function
extracellular zinc-dependent proteinase expressed during tissu remodelling processes (development, wound healing) and whose specific substrate is unknown
Homology
member of the matrix metalloproteinases (MMP) subfamily of matrixins
Implicated in
Entity name
various cancer:
Disease
expression of ST3 in 80 to 100% invasive carcinomas of the breast, colon, head and neck, lung, ovary, pancreas, prostate, skin (basal cell carcinoma), uterus (cervix carcinoma and endometrial carcinoma) and in some non-invasive carcinomas that have a high risk of evolving towards invasion; also expression in: fibroblastic stromal cells in the close vicinity of cancerous epithelial cells
Prognosis
prognostic factor of invasion and aggressiveness of the tumors
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 9502414 | 1998 | Stromelysin 3: an independent prognostic factor for relapse-free survival in node-positive breast cancer and demonstration of novel breast carcinoma cell expression. | Ahmad A et al |
| 7657606 | 1995 | Structure and promoter characterization of the human stromelysin-3 gene. | Anglard P et al |
| 1701851 | 1990 | A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas. | Basset P et al |
| 8980245 | 1996 | High levels of stromelysin-3 correlate with poor prognosis in patients with breast carcinoma. | Chenard MP et al |
| 9417124 | 1998 | Stromelysin-3 is induced in tumor/stroma cocultures and inactivated via a tumor-specific and basic fibroblast growth factor-dependent mechanism. | Mari BP et al |
| 9508784 | 1998 | In vivo evidence that the stromelysin-3 metalloproteinase contributes in a paracrine manner to epithelial cell malignancy. | Masson R et al |
| 7657519 | 1994 | Stromelysin-3 gene expression in human cancer: an overview. | Rouyer N et al |
Other Information
Locus ID:
NCBI: 4320
MIM: 185261
HGNC: 7157
Ensembl: ENSG00000099953
Variants:
dbSNP: 4320
ClinVar: 4320
TCGA: ENSG00000099953
COSMIC: MMP11
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000099953 | ENST00000215743 | P24347 |
| ENSG00000099953 | ENST00000428253 | F8WDI7 |
| ENSG00000099953 | ENST00000434318 | H7C3I7 |
| ENSG00000099953 | ENST00000437086 | E9PED7 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37633471 | 2024 | Cancer-associated fibroblasts drive early pancreatic cancer cell invasion via the SOX4/MMP11 signalling axis. | 1 |
| 37633471 | 2024 | Cancer-associated fibroblasts drive early pancreatic cancer cell invasion via the SOX4/MMP11 signalling axis. | 1 |
| 37602450 | 2023 | linc00511 Knockdown Inhibits Lung Cancer Progression by Regulating miR-16-5p/MMP11. | 1 |
| 37602450 | 2023 | linc00511 Knockdown Inhibits Lung Cancer Progression by Regulating miR-16-5p/MMP11. | 1 |
| 34775491 | 2022 | Matrix metalloproteinase 11 (MMP11) in macrophages promotes the migration of HER2-positive breast cancer cells and monocyte recruitment through CCL2-CCR2 signaling. | 22 |
| 35700579 | 2022 | Mechanism of miR-340-5p in laryngeal cancer cell proliferation and invasion through the lncRNA NEAT1/MMP11 axis. | 4 |
| 34775491 | 2022 | Matrix metalloproteinase 11 (MMP11) in macrophages promotes the migration of HER2-positive breast cancer cells and monocyte recruitment through CCL2-CCR2 signaling. | 22 |
| 35700579 | 2022 | Mechanism of miR-340-5p in laryngeal cancer cell proliferation and invasion through the lncRNA NEAT1/MMP11 axis. | 4 |
| 33649832 | 2021 | MMP11 promotes the proliferation and progression of breast cancer through stabilizing Smad2 protein. | 11 |
| 34038440 | 2021 | High MMP-11 expression associated with low CD8+ T cells decreases the survival rate in patients with breast cancer. | 13 |
| 33649832 | 2021 | MMP11 promotes the proliferation and progression of breast cancer through stabilizing Smad2 protein. | 11 |
| 34038440 | 2021 | High MMP-11 expression associated with low CD8+ T cells decreases the survival rate in patients with breast cancer. | 13 |
| 31335488 | 2020 | Expression of UTX Indicates Poor Prognosis in Patients With Luminal Breast Cancer and is Associated With MMP-11 Expression. | 1 |
| 32590618 | 2020 | Matrix Metalloproteinase 11 as a Novel Tumor Promoter and Diagnostic and Prognostic Biomarker for Pancreatic Ductal Adenocarcinoma. | 8 |
| 33228130 | 2020 | Impact of Matrix Metalloproteinase-11 Gene Polymorphisms on Biochemical Recurrence and Clinicopathological Characteristics of Prostate Cancer. | 5 |
Citation
Paul Basset ; Marie-Christine Rio
MMP11 (matrix metalloproteinase 11 (stromelysin 3))
Atlas Genet Cytogenet Oncol Haematol. 2000-03-01
Online version: http://atlasgeneticsoncology.org/gene/200/mmp11
