SYNPO2 (synaptopodin 2)

2003-12-01   Jian-Hua Luo 

Gene Array Laboratory, Univeristy of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

Identity

HGNC
SYNPO2
LOCATION
4q26
LOCUSID
171024
ALIAS
-
FUSION GENES
Show Gene Fusions

DNA/RNA

Atlas Image
Genome structure of myopodin and synaptopodin 2. Green represents exons of myopodin, and orange synaptopodin 2. Introns are indicated with lines.

Description

The genome sequence of myopodin contains 6.8 Kb, while synaptopodin 2 38 kb.

Transcription

A typical messenger RNA of myopodin is 4.2-4.4 kb, and synaptopodin 2 6.7 kb.

Pseudogene

Unknown

Proteins

Atlas Image
Protein structure of myopodin and synaptopodin 2. Orange represents sequence unique to synaptopodin 2, Green myopodin. Black stripe represents sequence homologous to synaptopodin 1.

Description

A nuclear localization signal is identified in N-terminus region of myopodin. Myopodin also contains six stretches of homologous sequences with synaptopodin 1.

Expression

Skeletal muscle, prostate, large and small intestine.

Localisation

Nucleus, cytoplasm.

Function

Actin bundling.

Homology

Synaptopodin

Mutations

Germinal

Not known

Somatic

Deletion

Implicated in

Disease
Prostate cancer and urothelial cell carcinoma.
Prognosis
Deletion preferentially occurs in aggressive type of prostate cancer. Loss of expression in nucleus in urothelial cell carcinoma is predictive of poor clinical outcome.
Cytogenetics
Not known

Bibliography

Pubmed IDLast YearTitleAuthors
116964202001Myopodin, a synaptopodin homologue, is frequently deleted in invasive prostate cancers.Lin F et al
129176312003Tumor suppressor role for myopodin in bladder cancer: loss of nuclear expression of myopodin is cell-cycle dependent and predicts clinical outcome.Sanchez-Carbayo M et al
116734752001Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein.Weins A et al

Other Information

Locus ID:

NCBI: 171024
HGNC: 17732
Ensembl: ENSG00000172403

Variants:

dbSNP: 171024
ClinVar: 171024
TCGA: ENSG00000172403
COSMIC: SYNPO2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172403ENST00000307142Q9UMS6
ENSG00000172403ENST00000429713Q9UMS6
ENSG00000172403ENST00000434046Q9UMS6
ENSG00000172403ENST00000448416B4E258
ENSG00000172403ENST00000504178H0Y9Y3
ENSG00000172403ENST00000610556Q9UMS6
ENSG00000172403ENST00000627783Q9UMS6
ENSG00000172403ENST00000627783B4DLE4

Expression (GTEx)

0
100
200
300
400
500
600
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
151113262004Expression of myopodin induces suppression of tumor growth and metastasis.19
178283782008Interaction between importin 13 and myopodin suggests a nuclear import pathway for myopodin.13
274705162016Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM.13
203320992010A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.8
222525222012Diagnostic and prognostic utility of methylation and protein expression patterns of myopodin in colon cancer.8
289913742018Synaptopodin-2 suppresses metastasis of triple-negative breast cancer via inhibition of YAP/TAZ activity.8
258832132015Synaptopodin-2 induces assembly of peripheral actin bundles and immature focal adhesions to promote lamellipodia formation and prostate cancer cell migration.7
193603532009Down-regulation of myopodin expression reduces invasion and motility of PC-3 prostate cancer cells.6
183712992008Multiple isoforms of the tumor suppressor myopodin are simultaneously transcribed in cancer cells.5
216430112011Phosphorylation and interaction of myopodin by integrin-link kinase lead to suppression of cell growth and motility in prostate cancer cells.5

Citation

Jian-Hua Luo

SYNPO2 (synaptopodin 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/488/synpo2