SYNPO2 (synaptopodin 2)
2003-12-01 Jian-Hua Luo AffiliationGene Array Laboratory, Univeristy of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
DNA/RNA
Genome structure of myopodin and synaptopodin 2. Green represents exons of myopodin, and orange synaptopodin 2. Introns are indicated with lines.
Description
The genome sequence of myopodin contains 6.8 Kb, while synaptopodin 2 38 kb.
Transcription
A typical messenger RNA of myopodin is 4.2-4.4 kb, and synaptopodin 2 6.7 kb.
Pseudogene
Unknown
Proteins
Protein structure of myopodin and synaptopodin 2. Orange represents sequence unique to synaptopodin 2, Green myopodin. Black stripe represents sequence homologous to synaptopodin 1.
Description
A nuclear localization signal is identified in N-terminus region of myopodin. Myopodin also contains six stretches of homologous sequences with synaptopodin 1.
Expression
Skeletal muscle, prostate, large and small intestine.
Localisation
Nucleus, cytoplasm.
Function
Actin bundling.
Homology
Synaptopodin
Mutations
Germinal
Not known
Somatic
Deletion
Implicated in
Disease
Prostate cancer and urothelial cell carcinoma.
Prognosis
Deletion preferentially occurs in aggressive type of prostate cancer. Loss of expression in nucleus in urothelial cell carcinoma is predictive of poor clinical outcome.
Cytogenetics
Not known
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 11696420 | 2001 | Myopodin, a synaptopodin homologue, is frequently deleted in invasive prostate cancers. | Lin F et al |
| 12917631 | 2003 | Tumor suppressor role for myopodin in bladder cancer: loss of nuclear expression of myopodin is cell-cycle dependent and predicts clinical outcome. | Sanchez-Carbayo M et al |
| 11673475 | 2001 | Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein. | Weins A et al |
Other Information
Locus ID:
NCBI: 171024
HGNC: 17732
Ensembl: ENSG00000172403
Variants:
dbSNP: 171024
ClinVar: 171024
TCGA: ENSG00000172403
COSMIC: SYNPO2
RNA/Proteins
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38038167 | 2024 | SYNPO2 promotes the development of BLCA by upregulating the infiltration of resting mast cells and increasing the resistance to immunotherapy. | 0 |
| 38038167 | 2024 | SYNPO2 promotes the development of BLCA by upregulating the infiltration of resting mast cells and increasing the resistance to immunotherapy. | 0 |
| 38201288 | 2023 | Synaptopodin-2 Isoforms Have Specific Binding Partners and Display Distinct, Muscle Cell Type-Specific Expression Patterns. | 0 |
| 38201288 | 2023 | Synaptopodin-2 Isoforms Have Specific Binding Partners and Display Distinct, Muscle Cell Type-Specific Expression Patterns. | 0 |
| 34333382 | 2021 | SYNPO2 suppresses hypoxia-induced proliferation and migration of colorectal cancer cells by regulating YAP-KLF5 axis. | 8 |
| 34333382 | 2021 | SYNPO2 suppresses hypoxia-induced proliferation and migration of colorectal cancer cells by regulating YAP-KLF5 axis. | 8 |
| 32278815 | 2020 | Synaptopodin-2 promotes hepatocellular carcinoma metastasis via calcineurin-induced nuclear-cytoplasmic translocation. | 8 |
| 32278815 | 2020 | Synaptopodin-2 promotes hepatocellular carcinoma metastasis via calcineurin-induced nuclear-cytoplasmic translocation. | 8 |
| 28991374 | 2018 | Synaptopodin-2 suppresses metastasis of triple-negative breast cancer via inhibition of YAP/TAZ activity. | 28 |
| 28991374 | 2018 | Synaptopodin-2 suppresses metastasis of triple-negative breast cancer via inhibition of YAP/TAZ activity. | 28 |
| 28231729 | 2017 | Association of a common variant of SYNPO2 gene with increased risk of serous epithelial ovarian cancer. | 3 |
| 28231729 | 2017 | Association of a common variant of SYNPO2 gene with increased risk of serous epithelial ovarian cancer. | 3 |
| 27470516 | 2016 | Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM. | 40 |
| 27592258 | 2016 | Myopodin methylation is a prognostic biomarker and predicts antiangiogenic response in advanced kidney cancer. | 6 |
| 27470516 | 2016 | Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM. | 40 |
Citation
Jian-Hua Luo
SYNPO2 (synaptopodin 2)
Atlas Genet Cytogenet Oncol Haematol. 2003-12-01
Online version: http://atlasgeneticsoncology.org/gene/488/synpo2
