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TCL1A (T-cell leukemia/lymphoma 1A)

Identity

Other namesTCL1 (T Cell Leukemia/Lymphoma 1)
HGNC (Hugo) TCL1A
Location 14q32.1
Location_base_pair Starts at 95246057 and ends at 95250286 bp from pter ( according to hg18-Mar_2006)  [Mapping]

DNA/RNA

Description 4 exons; telomere - exon 1 to 4 - centromere orientation
Transcription 1.3 kb transcripts

Protein

Description 114 amino acids; one domain with a b-barrel topology
Expression immature T and B lymphoid cells
Localisation cytoplasm
Function unknown
Homology MTCP1 (38 % identity, similar tridimentional structure)

Implicated in

Entity t(14;14)(q12;q32.1) or inv(14)(q12q32.1) /T-cell malignancies --> TCRA/D - TCL1
Disease mainly T-cell prolymphocytic leukemia (T-PLL); T- cell NHL; T-cell ALL
Cytogenetics associated with i(8q) in T-PLL
Hybrid/Mutated Gene none
Abnormal Protein none
Oncogenesis over expression of TCL1 is considered as critical in the oncogenetic mechanism
  
Entity t(7;14)(q35;q32.1)/T-cell malignancies --> TCRB - TCL1
Disease mainly T-cell prolymphocytic leukemia
Cytogenetics associated with i(8q)
Hybrid/Mutated Gene none
Abnormal Protein none
Oncogenesis over expression of TCL1
  

External links

Nomenclature
HGNC (Hugo)TCL1A   11648
Entrez_Gene (NCBI)TCL1A  8115  T-cell leukemia/lymphoma 1A
Cards
AtlasTCL1ID66
GeneCards (Weizmann)TCL1A
Ensembl (Hinxton)ENSG00000100721 [Gene_View]  TCL1A [Vega]
AceView (NCBI)TCL1A
Genatlas (Paris)TCL1A
euGene (Indiana)8115
SOURCE (Stanford)NM_001098725 NM_021966
Genomic and cartography
GoldenPath (UCSC)TCL1A  -  14q32.1   chr14:95246057-95250286 -  14q32.1   [Description]    (hg18-Mar_2006)
EnsemblTCL1A - 14q32.1 [CytoView]
Mapping of homologs : NCBITCL1A [Mapview]
OMIM186960   
Gene and transcription
Gene : Genbank (Entrez)BC003574 BC005831 BC009502 BC009891 BC014024
Reference sequence (RefSeq transcript) :SRSNM_001098725 NM_021966
Reference transcript : EntrezNM_001098725 NM_021966
RefSeq genomic : SRSAC_000057 AC_000146 NC_000014 NT_026437 NW_001838115 NW_925561
RefSeq genomic : EntrezAC_000057 AC_000146 NC_000014 NT_026437 NW_001838115 NW_925561
Consensus coding sequences : CCDS NCBITCL1A
Cluster EST : UnigeneHs.2484 [ SRS ] Hs.2484 [ NCBI ]
Alternative Splicing : Fast-db (Paris)5451
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtP56279 (SRS) P56279 (Expasy) P56279 (Uniprot)
With graphics : InterProP56279
Splice isoforms : VarSplice FASTAP56279(VarSplice FASTA)
Domains : Interpro (SRS)TCL1_MTCP1   
Domains : Interpro (EBI)TCL1_MTCP1   
Related proteins : CluSTrP56279
Domain families : Pfam SRSTCL1_MTCP1 (PF01840)   
Domain families : Pfam SangerTCL1_MTCP1 (PF01840)   
Domain families : Pfam NCBIpfam01840   
Domain structure : Prodom (Prabi Lyon)TCL1_MTCP1 (PD015575)   
Blocks (Seattle)P56279
Crystal structure of protein : PDB SRS1JSG   
Crystal structure of protein : PDBSum1JSG   
Crystal structure of protein : IMB1JSG   
Crystal structure of protein : PDB RSDB1JSG   
HPRD01744
Protein Interaction databases
DIP (DOE-UCLA)P56279
IntAct (EBI)P56279
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBITCL1A
SNP : GeneSNP UtahTCL1A
SNP : HGBaseTCL1A
Genetic variants : HAPMAPTCL1A
Somatic Mutations in Cancer : COSMICTCL1A 
Mutations and Diseases : HGMDTCL1A
Hereditary diseases : OMIM186960   
Hereditary diseases : GENETests186960   
Diseases : Genetic AssociationTCL1A
General knowledge
Homologs : HomoloGeneTCL1A
Homology/Alignments : Family Browser UCSCTCL1A
Phylogenetic Trees/Animal Genes : TreeFamTCL1A
Chemical/Protein Interactions : CTD8115
Keywords Ontology : AmiGOprotein binding  nucleus  cytoplasm  endoplasmic reticulum  microsome  multicellular organismal development  
Keywords Ontology : EGO-EBIprotein binding  nucleus  cytoplasm  endoplasmic reticulum  microsome  multicellular organismal development  
Pathways : BIOCARTA
Pathways : KEGG
Other databases
Probes
Probes : ImagenesTCL1A Related clones (RZPD - Berlin)
Literature
PubMed32 Pubmed reference(s) in Entrez
PubGeneTCL1A

Bibliography

Chromosome walking on the TCL1 locus involved in T-cell neoplasia.
Virgilio L, Isobe M, Narducci MG, Carotenuto P, Camerini B, Kurosawa N, Abbas-ar-Rushdi, Croce CM, Russo G
Proceedings of the National Academy of Sciences of the United States of America. 1993 ; 90 (20) : 9275-9279.
PMID 8415691
 
Characterization and localization of the TCL-1 oncogene product.
Fu TB, Virgilio L, Narducci MG, Facchiano A, Russo G, Croce CM
Cancer research. 1994 ; 54 (24) : 6297-6301.
PMID 7987816
 
Identification of the TCL1 gene involved in T-cell malignancies.
Virgilio L, Narducci MG, Isobe M, Billips LG, Cooper MD, Croce CM, Russo G
Proceedings of the National Academy of Sciences of the United States of America. 1994 ; 91 (26) : 12530-12534.
PMID 7809072
 
TCL1 oncogene activation in preleukemic T cells from a case of ataxia-telangiectasia.
Narducci MG, Virgilio L, Isobe M, Stoppacciaro A, Elli R, Fiorilli M, Carbonari M, Antonelli A, Chessa L, Croce CM, Russo G
Blood. 1995 ; 86 (6) : 2358-2364.
PMID 7662982
 
Expression of either the TCL1 oncogene, or transcripts from its homologue MTCP1/c6.1B, in leukaemic and non-leukaemic T cells from ataxia telangiectasia patients.
Thick J, Metcalfe JA, Mak YF, Beatty D, Minegishi M, Dyer MJ, Lucas G, Taylor AM
Oncogene. 1996 ; 12 (2) : 379-386.
PMID 8570215
 
TCL1 is overexpressed in patients affected by adult T-cell leukemias.
Narducci MG, Stoppacciaro A, Imada K, Uchiyama T, Virgilio L, Lazzeri C, Croce CM, Russo G
Cancer research. 1997 ; 57 (24) : 5452-5456.
PMID 9407948
 
The murine Tcl1 oncogene: embryonic and lymphoid cell expression.
Narducci MG, Virgilio L, Engiles JB, Buchberg AM, Billips L, Facchiano A, Croce CM, Russo G, Rothstein JL
Oncogene. 1997 ; 15 (8) : 919-926.
PMID 9285687
 
Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology.
Hoh F, Yang YS, Guignard L, Padilla A, Stern MH, Lhoste JM, van Tilbeurgh H
Structure (London, England : 1993). 1998 ; 6 (2) : 147-155.
PMID 9519406
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written03-1998Marc-Henri Stern

Citation

This paper should be referenced as such :
Stern MH . TCL1A (T-cell leukemia/lymphoma 1A). Atlas Genet Cytogenet Oncol Haematol. March 1998 .
URL : http://AtlasGeneticsOncology.org/Genes/TCL1ID66.html

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indexed on : Sat Jun 27 16:40:31 CEST 2009

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