TRB (T cell Receptor Beta)

2000-07-01   Marie-Paule Lefranc 

IMGT, LIGM, IGH, UPR CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France

Identity

HGNC
TRB
LOCATION
7q34
IMAGE
Atlas Image
LEGEND
for complete Figure, see: chromosome 7, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark
LOCUSID
6957
ALIAS
TCRB,TRB@

DNA/RNA

Atlas Image
TRB
V-GENE: Green box: Functional; Red: Pseudogene.
D-GENE: Blue: Functional.
J-GENE: Yellow: Functional; Pale yellow: Open reading frame; Red: pseudogene.
C-GENE: Blue: Functional.
for complete Figure, see: locus TRB, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark
TRB
V-GENE: Green box: Functional; Yellow box: Open reading frame; Red: Pseudogene.
D-GENE: Blue: Functional.
J-GENE: Grey: Functional .
C-GENE: Blue: Functional.
GENES NOT RELATED: Purple: Functional; Purple open box: Pseudogene.
for complete Figure, see: locus TRB, IGMT (The international ImMunoGeneTics information system) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark

Description

  • The human TRB locus at 7q35 spans 620 kb. It consists of 64-67 TRBV genes belonging to 32 subgroups.
  • Except for TRBV30, localized downstream of the TRBC2 gene, in inverted orientation of transcription, all the other TRBV genes are located upstream of a duplicated D-J-C-cluster, which comprises, for the first part one TRBD, six TRBJ, and the TRBC1 gene, and for the second part, one TRBD, eight TRBJ, and the TRBC2 gene.
  • The most 5 TRBV genes occupy the most centromeric position, whereas the TRBV30 gene, 3 of the locus, is the most telomeric gene in the TRB locus.
  • The potentiel repertoire consists of 39-46 functional TRBV genes belonging to 21-23 subgroups, the two TRBD, thirteen TRBJ (6 from the first cluster and 7 from the second cluster), and the two TRBC genes.
  • Six TRBV orphons have been localized on chromosome 9 at 9p21. Enhancer sequences have been characterized 5.5kb 3 from TRBC2.
  • List of the human TRB genes

    • Mutations

    Note

    Mutations which correspond to allelic polymorphisms of the functional germline TRBV, TRBD, TRBJ and TRBC genes are described in the IMGT database: (IMGT Repertoire>Alignments of alleles)

    Implicated in

    Entity name
    Translocations which frequently result from errors of the recombinase enzyme complexe (RAG1, RAG2, etc.), responsable of the Immunoglobulin and T cell receptor V-J and V-D-J rearrangements. TRBV, TRBD or TRBJ recombination signals or isolated heptamer are frequently observed at the breakpoints
    Entity name
    t(1;7)(p34;q35); involve TRB - LCK in 1p34
    Disease
    T-cell acute lymphocytic leukemia (ALL)
    Entity name
    t(1;7)(p32;q35); involve TRB - TAL1 in 1p32
    Disease
    T-cell acute lymphocytic leukemia (ALL)
    Prognosis
    median survival > 5 yrs in children
    Entity name
    t(7;9)(q35;q32); involve TRB - TAL2 in 9q32
    Disease
    T-cell acute lymphocytic leukemia (ALL)
    Entity name
    t(7;9)(q35;q34); involve TRB - TAN1 in 9q34
    Disease
    T-cell acute lymphocytic leukemia (ALL)
    Entity name
    t(7;10)(q35;q24); involve TRB - HOX11 in 10q24
    Disease
    T- cell acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL)
    Prognosis
    not unfavourable
    Entity name
    t(7;11)(q35;p13); involve TRB - RBTN2 in 11p13
    Disease
    T-cell acute lymphocytic leukemia (ALL)
    Entity name
    t(7;14)(q35;q32); involve TRB - TCL1 in 14q32
    Disease
    T-cell lymphoproliferations
    Entity name
    t(7;19)(q35;p13); involve TRB - LYL1 in 19p13
    Disease
    T-cell acute lymphoblastic leukemia (ALL)

    Breakpoints

    Atlas Image

    Other Information

    Locus ID:

    NCBI: 6957
    HGNC: 12155

    Variants:

    dbSNP: 6957
    ClinVar: 6957
    COSMIC: TRB

    References

    Pubmed IDYearTitleCitations
    197068842009Comprehensive assessment of T-cell receptor beta-chain diversity in alphabeta T cells.390
    213832442011A mechanism for TCR sharing between T cell subsets and individuals revealed by pyrosequencing.79
    169688992007Efficiency of T-cell receptor expression in dual-specific T cells is controlled by the intrinsic qualities of the TCR chains within the TCR-CD3 complex.59
    182758292008The structural dynamics and energetics of an immunodominant T cell receptor are programmed by its Vbeta domain.56
    183787922008A minimal binding footprint on CD1d-glycolipid is a basis for selection of the unique human NKT TCR.46
    238782182013Dietary gluten triggers concomitant activation of CD4+ and CD8+ αβ T cells and γδ T cells in celiac disease.46
    216733452011Novel adoptive T-cell immunotherapy using a WT1-specific TCR vector encoding silencers for endogenous TCRs shows marked antileukemia reactivity and safety.39
    254224322014Molecular architecture of the αβ T cell receptor-CD3 complex.37
    230910592012Cholesterol and sphingomyelin drive ligand-independent T-cell antigen receptor nanoclustering.35
    190566902009An early decrease in Notch activation is required for human TCR-alphabeta lineage differentiation at the expense of TCR-gammadelta T cells.33

    Citation

    Marie-Paule Lefranc

    TRB (T cell Receptor Beta)

    Atlas Genet Cytogenet Oncol Haematol. 2000-07-01

    Online version: http://atlasgeneticsoncology.org/gene/24/trb