TRB (T cell Receptor Beta)
2000-07-01 Marie-Paule Lefranc AffiliationIMGT, LIGM, IGH, UPR CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France
Identity
HGNC
LOCATION
7q34
IMAGE
LEGEND
for complete Figure, see: chromosome 7, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark
LOCUSID
ALIAS
TCRB,TRB@
DNA/RNA
TRB
V-GENE: Green box: Functional; Red: Pseudogene.
D-GENE: Blue: Functional.
J-GENE: Yellow: Functional; Pale yellow: Open reading frame; Red: pseudogene.
C-GENE: Blue: Functional.
for complete Figure, see: locus TRB, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark
V-GENE: Green box: Functional; Red: Pseudogene.
D-GENE: Blue: Functional.
J-GENE: Yellow: Functional; Pale yellow: Open reading frame; Red: pseudogene.
C-GENE: Blue: Functional.
for complete Figure, see: locus TRB, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark
TRB
V-GENE: Green box: Functional; Yellow box: Open reading frame; Red: Pseudogene.
D-GENE: Blue: Functional.
J-GENE: Grey: Functional .
C-GENE: Blue: Functional.
GENES NOT RELATED: Purple: Functional; Purple open box: Pseudogene.
for complete Figure, see: locus TRB, IGMT (The international ImMunoGeneTics information system) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark
V-GENE: Green box: Functional; Yellow box: Open reading frame; Red: Pseudogene.
D-GENE: Blue: Functional.
J-GENE: Grey: Functional .
C-GENE: Blue: Functional.
GENES NOT RELATED: Purple: Functional; Purple open box: Pseudogene.
for complete Figure, see: locus TRB, IGMT (The international ImMunoGeneTics information system) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark
Description
Mutations
Note
Mutations which correspond to allelic polymorphisms of the functional germline TRBV, TRBD, TRBJ and TRBC genes are described in the IMGT database: (IMGT Repertoire>Alignments of alleles)
Implicated in
Entity name
Translocations which frequently result from errors of the recombinase enzyme complexe (RAG1, RAG2, etc.), responsable of the Immunoglobulin and T cell receptor V-J and V-D-J rearrangements. TRBV, TRBD or TRBJ recombination signals or isolated heptamer are frequently observed at the breakpoints
Entity name
Disease
T-cell acute lymphocytic leukemia (ALL)
Entity name
Disease
T-cell acute lymphocytic leukemia (ALL)
Prognosis
median survival > 5 yrs in children
Entity name
Disease
T-cell acute lymphocytic leukemia (ALL)
Entity name
Disease
T-cell acute lymphocytic leukemia (ALL)
Entity name
Disease
T- cell acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL)
Prognosis
not unfavourable
Entity name
Disease
T-cell acute lymphocytic leukemia (ALL)
Entity name
Disease
T-cell lymphoproliferations
Entity name
Disease
T-cell acute lymphoblastic leukemia (ALL)
Breakpoints
Other Information
Locus ID:
Variants:
dbSNP: 6957
ClinVar: 6957
COSMIC: TRB
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38185632 | 2024 | The spike-specific TCRβ repertoire shows distinct features in unvaccinated or vaccinated patients with SARS-CoV-2 infection. | 0 |
| 38185632 | 2024 | The spike-specific TCRβ repertoire shows distinct features in unvaccinated or vaccinated patients with SARS-CoV-2 infection. | 0 |
| 38017021 | 2023 | Characterization of the TCRβ repertoire of peripheral MR1-restricted MAIT cells in psoriasis vulgaris patients. | 0 |
| 38017021 | 2023 | Characterization of the TCRβ repertoire of peripheral MR1-restricted MAIT cells in psoriasis vulgaris patients. | 0 |
| 33912187 | 2021 | Response to Hypomethylating Agents in Myelodysplastic Syndrome Is Associated With Emergence of Novel TCR Clonotypes. | 6 |
| 33912187 | 2021 | Response to Hypomethylating Agents in Myelodysplastic Syndrome Is Associated With Emergence of Novel TCR Clonotypes. | 6 |
| 31237711 | 2020 | The 3A6-TCR/superagonist/HLA-DR2a complex shows similar interface and reduced flexibility compared to the complex with self-peptide. | 0 |
| 31589793 | 2020 | Geometrical characterization of T cell receptor binding modes reveals class-specific binding to maximize access to antigen. | 12 |
| 32532817 | 2020 | T cell receptor interactions with human leukocyte antigen govern indirect peptide selectivity for the cancer testis antigen MAGE-A4. | 14 |
| 31237711 | 2020 | The 3A6-TCR/superagonist/HLA-DR2a complex shows similar interface and reduced flexibility compared to the complex with self-peptide. | 0 |
| 31589793 | 2020 | Geometrical characterization of T cell receptor binding modes reveals class-specific binding to maximize access to antigen. | 12 |
| 32532817 | 2020 | T cell receptor interactions with human leukocyte antigen govern indirect peptide selectivity for the cancer testis antigen MAGE-A4. | 14 |
| 31558465 | 2019 | Mismatched related vs matched unrelated donors in TCRαβ/CD19-depleted HSCT for primary immunodeficiencies. | 21 |
| 31558465 | 2019 | Mismatched related vs matched unrelated donors in TCRαβ/CD19-depleted HSCT for primary immunodeficiencies. | 21 |
| 27649554 | 2017 | The T-cell Receptor Repertoire Influences the Tumor Microenvironment and Is Associated with Survival in Aggressive B-cell Lymphoma. | 47 |
Citation
Marie-Paule Lefranc
TRB (T cell Receptor Beta)
Atlas Genet Cytogenet Oncol Haematol. 2000-07-01
Online version: http://atlasgeneticsoncology.org/gene/24/trb
