| Identity |
| Other names | TRD (T cell Receptor Delta) |
| HGNC (Hugo) | TRD@ |
| Location | 14q11.2 |
| Location_base_pair | Starts at 21961571 and ends at 22001823 bp from pter ( according to hg18-Mar_2006) |
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| for complete Figure, see: chromosome 14, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2003 IMGT, IMGT is a CNRS trademark | |
| Note | The TRD locus is embedded in the TRA locus, between the TRAV and TRAJ genes. The orientation of the locus has been determined by the analysis of translocations, involving the TRD locus, in leukemia and lymphoma |
| DNA/RNA |
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| TRA/TRD V-GENE: Green box: Functional; Red: Pseudogene. D-GENE: Blue: Functional. J-GENE: Yellow: Functional; Pale yellow: Open reading frame; Red: Pseudogene. C-GENE: Blue: Functional. for complete Figure, see: locus TRD, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2003 IMGT, IMGT is a CNRS trademark | |
| Description | |
| Protein |
| Description | |
| Mutations |
| Note | Mutations which correspond to allelic polymorphisms of the functional germline TRDV, TRDD, TRDJ and TRDC genes are described in the IMGT database: (IMGT Repertoire>Alignments of alleles) |
| Implicated in |
| Entity | Translocations which frequently result from errors of the recombinase enzyme complexe (RAG1, RAG2, etc.), responsable of the Immunoglobulin and T cell receptor V-J and V-D-J rearrangements. TRDV, TRDD or TRDJ recombination signals or isolated heptamer are frequently observed at the breakpoints. |
| Entity | t(1;14)(p32;q11); involve TAL1 in 1p32 |
| Prognosis | median survival > 5 yrs in children |
| Entity | t(8;14)(q24;q11); involve MYC in 8q24 |
| Disease | T-cell acute lymphocytic leukemia (ALL); rare |
| Entity | t(10;14)(q24;q11); involve HOX11 in 10q24 |
| Disease | T- cell acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL) |
| Prognosis | not unfavourable |
| Entity | t(11;14)(p13;q11); involve RBTN2 in 11p13 |
| Disease | T-cell acute lymphocytic leukemia (ALL) |
| Entity | t(11;14)(p15;q11); involve RBTN1 in 11p15 |
| Disease | T-cell Acute lymphocytic leukemia (ALL) |
| Entity | t(14;14)(q11;q32), inv(14)(q11q32); involve TCL1 in 14q32 |
| Disease | T-cell prolymphocytic leukemia (T-PLL) and adult T cell leukemia/lymphoma |
| Prognosis | poor |
| Breakpoints |
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| External links |
| Nomenclature | |
|---|---|
| HGNC (Hugo) | TRD@ 12252 |
| Entrez_Gene (NCBI) | TRD@ 6964 T cell receptor delta locus |
| Cards | |
| Atlas | TCRDID279 |
| GeneCards (Weizmann) | TRD@ |
| Ensembl (Hinxton) | ENSG00000124678 [Gene_View] TRD@ [Vega] |
| AceView (NCBI) | TRD@ |
| Genatlas (Paris) | TRD@ |
| euGene (Indiana) | 6964 |
| SOURCE (Stanford) | |
| Gene Expression (Array Express) | ENSG00000124678 |
| Genomic and cartography | |
| GoldenPath (UCSC) | TRD@ - 14q11.2 chr14:21961571-22001823 + 14q11.2 [Description] (hg18-Mar_2006) |
| Ensembl | TRD@ - 14q11.2 [CytoView] |
| Mapping of homologs : NCBI | TRD@ [Mapview] |
| OMIM | 186810 |
| Gene and transcription | |
| Gene : Genbank (Entrez) | AF512436 AF512438 AF512442 AJ583013 AK301085 |
| Reference sequence (RefSeq transcript) :SRS | |
| Reference transcript : Entrez | |
| RefSeq genomic : SRS | NC_000014 NG_001332 NT_026437 |
| RefSeq genomic : Entrez | NC_000014 NG_001332 NT_026437 |
| Consensus coding sequences : CCDS NCBI | TRD@ |
| Cluster EST : Unigene | Hs.713514 [ SRS ] Hs.713514 [ NCBI ] |
| Protein : pattern, domain, 3D structure | |
| Domain families : Pfam SRS | |
| Domain families : Pfam Sanger | |
| Domain families : Pfam NCBI | |
| Crystal structure of protein : PDB SRS | |
| Crystal structure of protein : PDBSum | |
| Crystal structure of protein : IMB | |
| Crystal structure of protein : PDB RSDB | |
| Protein Interaction databases | |
| Polymorphism : SNP, mutations, diseases | |
| Single Nucleotide Polymorphism (SNP) : dbSNP NCBI | TRD@ |
| SNP : GeneSNP Utah | TRD@ |
| SNP : HGBase | TRD@ |
| Genetic variants : HAPMAP | TRD@ |
| Cancer Gene: Census | TRD@ |
| Mutations and Diseases : HGMD | TRD@ |
| Hereditary diseases : OMIM | 186810 |
| Hereditary diseases : GENETests | 186810 |
| Diseases : Genetic Association | TRD@ |
| General knowledge | |
| Homologs : HomoloGene | TRD@ |
| Homology/Alignments : Family Browser UCSC | TRD@ |
| Phylogenetic Trees/Animal Genes : TreeFam | TRD@ |
| Chemical/Protein Interactions : CTD | 6964 |
| Keywords Ontology : AmiGO | |
| Keywords Ontology : EGO-EBI | |
| Pathways : BIOCARTA | |
| Pathways : KEGG | |
| Other databases | |
| Other database | TRD@ - IMGT |
| Probes | |
| Probe | Probes IMGT |
| Probes : Imagenes | TRD@ Related clones (RZPD - Berlin) |
| Literature | |
| PubMed | 29 Pubmed reference(s) in Entrez |
| PubGene | TRD@ |
| Bibliography |
| Nomenclature of the human T cell Receptor genes (Review) |
| Lefranc MP |
| Current Protocols in Immunology. 2000. |
| The T cell Receptor FactsBook (Review) |
| Lefranc MP and Lefranc G |
| Academic Press, London, UK (. 1939. |
| Locus Map and Genomic repertoire of the Human Immunoglobulin Genes (Review) |
| Lefranc MP |
| The immunologist,. 2000. |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| Contributor(s) |
| Written | 07-2000 | Marie-Paule Lefranc |
| Updated | 09-2003 | Marie-Paule Lefranc |
| Citation |
| This paper should be referenced as such : |
| Lefranc MP . TRD@ (T cell Receptor Delta). Atlas Genet Cytogenet Oncol Haematol. July 2000 . URL : http://AtlasGeneticsOncology.org/Genes/TCRDID279.html |
| Lefranc MP . TRD@ (T cell Receptor Delta). Atlas Genet Cytogenet Oncol Haematol. September 2003 . URL : http://AtlasGeneticsOncology.org/Genes/TCRDID279.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Feb 27 10:53:04 CET 2010 |
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