TRG (T cell Receptor Gamma)

2000-07-01   Marie-Paule Lefranc 

IMGT, LIGM, IGH, UPR CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France

Identity

HGNC
TRG
LOCATION
7p14
IMAGE
Atlas Image
LEGEND
for complete Figure, see: chromosome 7, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark
LOCUSID
6965
ALIAS
TCRG,TRG@
FUSION GENES
Show Gene Fusions

DNA/RNA

Atlas Image
TRG
V-GENE: Green box: Functional; Yellow box: Open reading frame; Red: Pseudogene; Triangle: Not sequenced.
J-GENE: Grey: Functional .
C-GENE: Blue: Functional.
for complete Figure, see: locus TRG, IMGT (The International ImMunoGeneTics information system ®) © Copyright 1995-2017 IMGT, IMGT is a CNRS trademark

Description

  • The human TRG locus at 7p15-p14 spans 160 kb. It consists of 12-15 TRGV genes belonging to 6 subgroups, upstream of a duplicated J-C-cluster, which comprises, for the first part, three TRGJ and the TRGC1 gene, and for the second part, two TRGJ and the TRGC2 gene.
  • The most 5 TRGV genes occupy the most centromeric position, whereas the TRGC2 gene, 3 of the locus, is the most telomeric in the TRG locus.
  • The potentiel repertoire consists of 4-6 functional TRGV genes belonging to two subgroups, the 5 TRGJ and the 2 TRGC genes.
  • Polymorphisms in the number of TRGV genes and in the exon number of the TRGC2 gene have been described in different populations.
  • Enhancer and silencer sequences have been characterized downstream of the TRGC2 gene
  • List of the human TRG genes

    • Mutations

    Note

    Mutations which correspond to allelic polymorphisms of the functional germline TRGV, TRGJ and TRGC genes are described in the IMGT database: (IMGT Repertoire>Alignments of alleles)

    Implicated in

    Entity name
    Inversions which result from errors of the recombinase enzyme complexe (RAG1, RAG2, etc.), responsable of the Immunoglobulin and T cell receptor V-J and V-D-J rearrangements. TRGV or TRGJ recombination signals or isolated heptamer are observed at the breakpoints

    Other Information

    Locus ID:

    NCBI: 6965
    HGNC: 12271

    Variants:

    dbSNP: 6965
    ClinVar: 6965
    COSMIC: TRG

    References

    Pubmed IDYearTitleCitations
    219825962011Pivotal role of dermal IL-17-producing γδ T cells in skin inflammation.268
    240766362013CD1d-lipid antigen recognition by the γδ TCR.97
    238782182013Dietary gluten triggers concomitant activation of CD4+ and CD8+ αβ T cells and γδ T cells in celiac disease.46
    198439472009Human gamma delta T cells: a lymphoid lineage cell capable of professional phagocytosis.44
    220459852011Control of Plasmodium falciparum erythrocytic cycle: γδ T cells target the red blood cell-invasive merozoites.42
    221804422012Antibody-dependent anti-cytomegalovirus activity of human γδ T cells expressing CD16 (FcγRIIIa).36
    272107462016RhoB Mediates Phosphoantigen Recognition by Vγ9Vδ2 T Cell Receptor.33
    258649152015The promise of γδ T cells and the γδ T cell receptor for cancer immunotherapy.27
    282858142017Thymic Determinants of γδ T Cell Differentiation.26
    186243052008Dysregulation of the host mevalonate pathway during early bacterial infection activates human TCR gamma delta cells.25

    Citation

    Marie-Paule Lefranc

    TRG (T cell Receptor Gamma)

    Atlas Genet Cytogenet Oncol Haematol. 2000-07-01

    Online version: http://atlasgeneticsoncology.org/gene/268/trg