TFF1 (trefoil factor 1)

2000-08-01 Catherine Tomasetto , Marie-Christine Rio Affiliation

I.G.B.M.C, 1, rue Laurent FRIES, BP 163 67404 ILLKIRH, France

Identity

HGNC

TFF1

LOCATION

21q22.3

LOCUSID

7031

ALIAS

BCEI,D21S21,HP1.A,HPS2,pNR-2,pS2

FUSION GENES

Show Gene Fusions

DNA/RNA

Description

5kb gene; 3 exons

Transcription

600bp cDNA; coding sequence: 252 bp

Proteins

Description

84 amino acids, containing a peptide signal; the 60 AA-long mature secreted peptide contains one TFF (TreFoil Factor) domain and one acidic C-terminal domain

Expression

epithelial cells of the stomach surface

Localisation

cytoplasmic

Function

in the maintenance of mucosa integrity; unknown at the molecular level; deficient mice develop antro-pyloric adenoma

Homology

TFF2/SP (spasmolytic peptide) and TFF3/ITF (intestinal trefoil factor)

Implicated in

Disease

overexpressed in estradiol-dependent breast carcinomas; overexpressed in carcinoma of several other organs; loss of expression in half of gastric carcinomas (TFF1 is normally expressed in the stomach)

Prognosis

good prognosis factor, and marker of response to hormonal treatment in breast carcinomas

Bibliography

Pubmed ID	Last Year	Title	Authors
2354435	1990	Prediction of relapse and survival in breast cancer patients by pS2 protein status.	Foekens JA et al
8824193	1996	Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein.	Lefebvre O et al
9739760	1998	The pS2/TFF1 trefoil factor, from basic research to clinical applications.	Ribieras S et al
8297741	1994	pS2 and response to adjuvant hormone therapy in primary breast cancer.	Spyratos F et al
10611155	2000	pS2/TFF1 interacts directly with the VWFC cysteine-rich domains of mucins.	Tomasetto C et al

Other Information

Locus ID:

NCBI: 7031
MIM: 113710
HGNC: 11755
Ensembl: ENSG00000160182

Variants:

dbSNP: 7031
ClinVar: 7031
TCGA: ENSG00000160182
COSMIC: TFF1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000160182	ENST00000291527	P04155

Expression (GTEx)

100

200

300

400

500

600

700

800

900

1000

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
18322525	2008	Cyclical DNA methylation of a transcriptionally active promoter.	325
21111741	2011	Inhibition of gastric carcinogenesis by the hormone gastrin is mediated by suppression of TFF1 epigenetic silencing.	47
21490402	2011	Loss of TFF1 is associated with activation of NF-κB-mediated inflammation and gastric neoplasia in mice and humans.	46
26240291	2015	Identification of a Three-Biomarker Panel in Urine for Early Detection of Pancreatic Adenocarcinoma.	39
12034770	2002	The trefoil factor 1 participates in gastrointestinal cell differentiation by delaying G1-S phase transition and reducing apoptosis.	38
16474375	2006	Early-onset gastric cancers have a different molecular expression profile than conventional gastric cancers.	34
21358676	2011	Deficiency in trefoil factor 1 (TFF1) increases tumorigenicity of human breast cancer cells and mammary tumor development in TFF1-knockout mice.	34
18676680	2008	Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.	32
15924415	2005	Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a brichos domain-containing protein with homology to SP-C.	30
12379766	2002	Loss of heterozygosity and promoter methylation, but not mutation, may underlie loss of TFF1 in gastric carcinoma.	25

Citation

Catherine Tomasetto ; Marie-Christine Rio

TFF1 (trefoil factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2000-08-01

Online version: http://atlasgeneticsoncology.org/gene/201/tff1