TFF1 (trefoil factor 1)
2000-08-01 Catherine Tomasetto , Marie-Christine Rio AffiliationI.G.B.M.C, 1, rue Laurent FRIES, BP 163 67404 ILLKIRH, France
Identity
HGNC
LOCATION
21q22.3
LOCUSID
ALIAS
BCEI,D21S21,HP1.A,HPS2,pNR-2,pS2
FUSION GENES
DNA/RNA
Description
5kb gene; 3 exons
Transcription
600bp cDNA; coding sequence: 252 bp
Proteins
Description
84 amino acids, containing a peptide signal; the 60 AA-long mature secreted peptide contains one TFF (TreFoil Factor) domain and one acidic C-terminal domain
Expression
epithelial cells of the stomach surface
Localisation
cytoplasmic
Function
in the maintenance of mucosa integrity; unknown at the molecular level; deficient mice develop antro-pyloric adenoma
Implicated in
Disease
overexpressed in estradiol-dependent breast carcinomas; overexpressed in carcinoma of several other organs; loss of expression in half of gastric carcinomas (TFF1 is normally expressed in the stomach)
Prognosis
good prognosis factor, and marker of response to hormonal treatment in breast carcinomas
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|
Other Information
Locus ID:
NCBI: 7031
MIM: 113710
HGNC: 11755
Ensembl: ENSG00000160182
Variants:
dbSNP: 7031
ClinVar: 7031
TCGA: ENSG00000160182
COSMIC: TFF1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000160182 | ENST00000291527 | P04155 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36758349 | 2023 | Study on TFF1 and PALB2 gene variants associated with gastric carcinoma risk in the Chinese Han population. | 0 |
| 37437926 | 2023 | The Transcription Factor RUNX1 Aggravates Hypoxia-Induced Human Retinal Microvascular Endothelial Cell Dysfunction by Negatively Regulating TFF1 Promoter. | 0 |
| 36758349 | 2023 | Study on TFF1 and PALB2 gene variants associated with gastric carcinoma risk in the Chinese Han population. | 0 |
| 37437926 | 2023 | The Transcription Factor RUNX1 Aggravates Hypoxia-Induced Human Retinal Microvascular Endothelial Cell Dysfunction by Negatively Regulating TFF1 Promoter. | 0 |
| 33660336 | 2022 | The trefoil factor family 1 (TFF-1) and 3 (TFF-3) are upregulated in the saliva, gingival crevicular fluid and serum of periodontitis patients. | 2 |
| 34219206 | 2022 | Circ-TFF1 Facilitates Breast Cancer Development via Regulation of miR-338-3p/FGFR1 Axis. | 6 |
| 35279702 | 2022 | Trefoil factor 1 inhibits the development of esophageal adenocarcinoma from Barrett's epithelium. | 0 |
| 35315403 | 2022 | Association between Promotor hypomethylation of TFF1 and Crohn's Disease. | 0 |
| 35987613 | 2022 | Association of functional genetic variants in TFF1 and nephrolithiasis risk in a Chinese population. | 0 |
| 36057754 | 2022 | TFF1 gene single nucleotide polymorphism (rs3761376) and colorectal cancer risk. | 1 |
| 36514982 | 2022 | IFNγ-dependent silencing of TFF1 during Helicobacter pylori infection. | 1 |
| 33660336 | 2022 | The trefoil factor family 1 (TFF-1) and 3 (TFF-3) are upregulated in the saliva, gingival crevicular fluid and serum of periodontitis patients. | 2 |
| 34219206 | 2022 | Circ-TFF1 Facilitates Breast Cancer Development via Regulation of miR-338-3p/FGFR1 Axis. | 6 |
| 35279702 | 2022 | Trefoil factor 1 inhibits the development of esophageal adenocarcinoma from Barrett's epithelium. | 0 |
| 35315403 | 2022 | Association between Promotor hypomethylation of TFF1 and Crohn's Disease. | 0 |
Citation
Catherine Tomasetto ; Marie-Christine Rio
TFF1 (trefoil factor 1)
Atlas Genet Cytogenet Oncol Haematol. 2000-08-01
Online version: http://atlasgeneticsoncology.org/gene/201/tff1
