TFF3 trefoil factor 3 (intestinal)
2001-03-01 Catherine Tomasetto AffiliationI.G.B.M.C., BP 163, 1 rue Laurent Fries, 67404 Illkirch, France
DNA/RNA
Description
3.3 kb gene, 3 exons
Transcription
600 bp
Proteins
Description
precursor 74 amino acids, mature peptide 51 aminoacids, trefoil domain from aminoacids residues 24 to 67. The 74 aminoacids TFF3 protein precusor contains a signal peptide. The mature secreted peptide of 51 aminoacids contains one TFF (TreFoil Factor) domain and one acidic C-terminal domain. The acidic C-terminal domain contains a free cystein residue that promotes homodimerization and heterodimerization.
Expression
Under normal conditions TFF3 is expressed by gobblet cell of the intesine and the colon. TFF3 expression was found in human respiratory tract, human conjunctival goblet cells and in human salivarygland. In addition TFF3 peptive was found in human hypothalamus.
Localisation
In secreterory epithelia TFF3 is expressed by mucin-producing cells. In the brain TFF3 is expressed by a population of neurons of the human hypothamic paraventricular and supraoptic nuclei.
Function
TFF3 promotes migration of epithelial cells in vitro and enhance mucosal healing and epithelial restitutions in vivo in the gastrointestinal mucosa. TFF3 deficient mice aresuceptible to colonic injury induced by standard agents and restitution is impaired. In addition TFF3 deficient mice have an increase in colonocyte apoptosis. The protective action of TFF3 involves activation of both EGF-R and PI3K-Akt pathways. The role of TFF3 in the brain is not clear yet.
Implicated in
Entity name
Inflamatory bowel diseases, TFF3 is expressed in cancer cells derived from the gastrointestinal tract, in hepatocellular carcinoma cells and in small cell lung carcinoma cells. Like TFF1, TFF3 is expressed in oestrogen-responsive breast cancer cell line and is expressed in breast cancer.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 8566596 | 1996 | Oral trefoil peptides protect against ethanol- and indomethacin-induced gastric injury in rats. | Babyatsky MW et al |
| 8001677 | 1995 | Characterisation of the single copy trefoil peptides intestinal trefoil factor and pS2 and their ability to form covalent dimers. | Chinery R et al |
| 9501226 | 1998 | Intestinal trefoil factor controls the expression of the adenomatous polyposis coli-catenin and the E-cadherin-catenin complexes in human colon carcinoma cells. | Efstathiou JA et al |
| 8346203 | 1993 | hP1.B, a human P-domain peptide homologous with rat intestinal trefoil factor, is expressed also in the ulcer-associated cell lineage and the uterus. | Hauser F et al |
| 10834934 | 2000 | Co-localization of TFF3 peptide and oxytocin in the human hypothalamus. | Jagla W et al |
| 9419349 | 1998 | Intestinal trefoil factor induces inactivation of extracellular signal-regulated protein kinase in intestinal epithelial cells. | Kanai M et al |
| 7615201 | 1995 | Trefoil peptide protection of intestinal epithelial barrier function: cooperative interaction with mucin glycoprotein. | Kindon H et al |
| 10848594 | 2000 | Distinct pathways of cell migration and antiapoptotic response to epithelial injury: structure-function analysis of human intestinal trefoil factor. | Kinoshita K et al |
| 10476786 | 1999 | Secretory peptides TFF1 and TFF3 synthesized in human conjunctival goblet cells. | Langer G et al |
| 8824194 | 1996 | Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor. | Mashimo H et al |
| 9306961 | 1997 | Expression of human intestinal trefoil factor in malignant cells and its regulation by oestrogen in breast cancer cells. | May FE et al |
| 10779222 | 2000 | Mechanisms of regulatory peptide action in the gastrointestinal tract: trefoil peptides. | Podolsky DK et al |
| 9370944 | 1997 | Intestinal trefoil factor (TFF 3) and pS2 (TFF 1), but not spasmolytic polypeptide (TFF 2) mRNAs are co-expressed in normal, hyperplastic, and neoplastic human breast epithelium. | Poulsom R et al |
| 8815795 | 1996 | The trefoil peptide family. | Sands BE et al |
| 9070946 | 1997 | The three human trefoil genes TFF1, TFF2, and TFF3 are located within a region of 55 kb on chromosome 21q22.3. | Seib T et al |
| 8463228 | 1993 | Physiologic concentrations of glucose regulate fatty acid synthase activity in HepG2 cells by mediating fatty acid synthase mRNA stability. | Semenkovich CF et al |
| 10639160 | 2000 | Intestinal trefoil factor confers colonic epithelial resistance to apoptosis. | Taupin DR et al |
| 9447240 | 1997 | Trefoil peptides: from structure to function. | Thim L et al |
| 10194185 | 1999 | Localization of TFF3, a new mucus-associated peptide of the human respiratory tract. | Wiede A et al |
Other Information
Locus ID:
NCBI: 7033
MIM: 600633
HGNC: 11757
Ensembl: ENSG00000160180
Variants:
dbSNP: 7033
ClinVar: 7033
TCGA: ENSG00000160180
COSMIC: TFF3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000160180 | ENST00000291525 | X6R3S7 |
| ENSG00000160180 | ENST00000398431 | H7BYT0 |
| ENSG00000160180 | ENST00000518498 | Q07654 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33660336 | 2022 | The trefoil factor family 1 (TFF-1) and 3 (TFF-3) are upregulated in the saliva, gingival crevicular fluid and serum of periodontitis patients. | 2 |
| 34756116 | 2022 | Low expression of TFF3 in papillary thyroid carcinoma may correlate with poor prognosis but high immune cell infiltration. | 4 |
| 35039476 | 2022 | Pathological and therapeutic roles of bioactive peptide trefoil factor 3 in diverse diseases: recent progress and perspective. | 19 |
| 35332126 | 2022 | Trefoil factor 3 promotes pancreatic carcinoma progression via WNT pathway activation mediated by enhanced WNT ligand expression. | 6 |
| 35833823 | 2022 | TFF3 promotes pituitary tumor cell migration and angiogenesis via VEGFA. | 1 |
| 35974137 | 2022 | Gut biomolecules (I-FABP, TFF3 and lipocalin-2) are associated with linear growth and biomarkers of environmental enteric dysfunction (EED) in Bangladeshi children. | 0 |
| 36499686 | 2022 | Different Molecular Forms of TFF3 in the Human Respiratory Tract: Heterodimerization with IgG Fc Binding Protein (FCGBP) and Proteolytic Cleavage in Bronchial Secretions. | 4 |
| 33660336 | 2022 | The trefoil factor family 1 (TFF-1) and 3 (TFF-3) are upregulated in the saliva, gingival crevicular fluid and serum of periodontitis patients. | 2 |
| 34756116 | 2022 | Low expression of TFF3 in papillary thyroid carcinoma may correlate with poor prognosis but high immune cell infiltration. | 4 |
| 35039476 | 2022 | Pathological and therapeutic roles of bioactive peptide trefoil factor 3 in diverse diseases: recent progress and perspective. | 19 |
| 35332126 | 2022 | Trefoil factor 3 promotes pancreatic carcinoma progression via WNT pathway activation mediated by enhanced WNT ligand expression. | 6 |
| 35833823 | 2022 | TFF3 promotes pituitary tumor cell migration and angiogenesis via VEGFA. | 1 |
| 35974137 | 2022 | Gut biomolecules (I-FABP, TFF3 and lipocalin-2) are associated with linear growth and biomarkers of environmental enteric dysfunction (EED) in Bangladeshi children. | 0 |
| 36499686 | 2022 | Different Molecular Forms of TFF3 in the Human Respiratory Tract: Heterodimerization with IgG Fc Binding Protein (FCGBP) and Proteolytic Cleavage in Bronchial Secretions. | 4 |
| 33401971 | 2021 | The diagnostic and clinicopathological value of trefoil factor 3 in patients with gastric cancer: a systematic review and meta-analysis. | 5 |
Citation
Catherine Tomasetto
TFF3 trefoil factor 3 (intestinal)
Atlas Genet Cytogenet Oncol Haematol. 2001-03-01
Online version: http://atlasgeneticsoncology.org/gene/265/tff3
