Institute for Myeloma & Bone Cancer Research, 9201 W. Sunset Blvd., Ste. 300, West Hollywood, CA 90069, USA
B Cell Maturation Antigen (BCMA) is a transmembrane signaling protein preferentially expressed on plasma cells. Its ligands include B-Cell Activating Factor (BAFF) and A Proliferation Inducing Ligand (APRIL). BCMA is involved in JNK and NF-kB activation pathways that induce B-cell development and autoimmune responses. BCMA has been implicated in autoimmune disorders as well as B-lymphocyte malignancies.
NCBI: 608 MIM: 109545 HGNC: 11913 Ensembl: ENSG00000048462
dbSNP: 608 ClinVar: 608 TCGA: ENSG00000048462 COSMIC: TNFRSF17
Abigail Gillespie ; Eric Sanchez ; George Tang ; Haiming Chen ; James Berenson
TNFRSF17 (tumor necrosis factor receptor superfamily, member 17)
Atlas Genet Cytogenet Oncol Haematol. 2014-10-01
Online version: http://atlasgeneticsoncology.org/gene/42616/tnfrsf17