Atlas of Genetics and Cytogenetics in Oncology and Haematology

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Chromosome 4

Chromosome 4 : G-banding, diagram and R-banding - Claude Léonard, Jean-Loup Huret
Chromosome 4 diagrams ISCN 2009 - Courtesy Nicole Chia

Leukaemia     

t(2;4)(p22;q12)
t(2;4)(p23;q25-q35)
t(3;4)(p21;q34)
t(3;4)(q27;p13)
ins(9;4)(q33;q12q25) (MPD; PDGFRa and CDK5RAP2; rare)
del(4)(q12q12) (MPD; PDGFRa and FIP1L1; not rare)
t(4;10)(q12;p11)
+4 or trisomy 4
t(4;5)(q21;q33)
t(4;5)(q31;q31)
ins(9;4)(q33;q12q25)
t(4;11)(p12;q23)
t(4;11)(q21;p15)
t(4;11)(q35;q23)
t(4;11)(q21;q23)
t(4;12)(p16;p13)
t(4;12)(q12;p13) PDGFRA/ETV6
t(4;12)(q11-q21;p13)
t(4;14)(p16;q32)
t(4;16)(q26;p13)
t(4;17)(q12;q21)
t(4;21)(q31;q22)
t(4;21)(q31;q22)
t(4;21)(q35;q22)
t(4;22)(q12;q11.2)

Solid Tumors     

Cancer prone diseases     

Familial /sporadic gastrointestinal stromal tumors (GISTs)
Piebaldism

All Genes by Location (Kb)
Chromosome 4 by location

Losses / Amplicons     

BONE/SOFT TISSUE

External links     

  • Chromosome 4 - HUGO Chromosomes
  • Chromosome 4 - GoldenPath - Santa Cruz
  • Chromosome 4 - Ensembl Project
  • Chromosome 4 - Map View - NCBI
  • Chromosome 4 - OMIM Gene map
  • Chromosome 4 - Genomic Variants
  • Chromosome 4 - HAPMAP Project
  • Chromosome 4 - Genome Channel - ORNL
  • Chromosome 4 - LaunchPad HGMIS
  • Chromosome 4 - Human Protein Atlas
  • Chromosome 4 - Array BAC clone - Roswell Park Cancer Institute
  • Chromosome 4 - Human BAC Resource (NCBI)
  • Chromosome 4 FISH-mapped BACs (CCAP)
  • Genetic Maps (CHLC)
  • YACs mapped by FISH (Bari)
  • PCP (Partial Chromosome Paints) (Bari)
  • Mouse homology - OMIM - NCBI
  • Chromosome 4 Cancer GeneWeb
  • Chromosome 4 GeneCards (Weizmann)
  • Human Proteomics Initiative (Expasy)

    • Genes

    Annotated genes
    Ordered by Name Ordered by Location
     Kb pter-qter
    AFF1 88005.269 4q21
    AREG 75480.628 4q13-q21
    CHIC2 54875.975 4q11
    EIF4E 99801.915 4q21-q25
    FGFR3 1795.033 4p16.3
    FRYL 48499.379 4p11
    HNRNPD 83274.493 4q21
    ING2 184426.262 4q35.1
    KIT 55593.649 4q11-q12
    MAPK10 86985.050 4q22.1-q23
    NR3C2 149002.429 4q31.1
    NUDT6 123818.680 4q26
    PTPN13 87556.505 4q21.3
    RAP1GDS1 99214.557 4q23-q25
    RASL11B 53728.483 4q12
    RASSF6 74449.357 4q13.3
    RCHY1 76406.824 4q21.1
    REST 57775.127 4q12
    RHOH 40245.006 4p13
    S100P 6694.795 4p16
    SYNPO2 119952.810 4q26
    TACC3 1723.265 4p16.3
    WHSC1 1953.831 4p16.3
    Other genes
    possibly implicated
    in cancer
    Ordered by Name Ordered by Location
     Kb pter-qter
    AASDH 57244.494 4q12
    ABCE1 146019.481 4q31
    ABCG2 89013.370 4q22
    ACOX3 8368.438 4p15.3
    ACSL1 185676.754 4q35
    ADAM29 175852.133 4q34
    ADAMTS3 73146.686 4q13.3
    ADH1A 100197.523 4q23
    ADH1B 100226.122 4q23
    ADH1C 100257.650 4q23
    ADH4 100045.513 4q21-q24|4q22
    ADH5 99996.375 4q23
    ADH6 100123.796 4q23
    ADH7 100333.781 4q23-q24
    AFAP1 7765.150 4p16
    AFM 74347.461 4q13.3
    AFP 74301.937 4q11-q13
    AGPAT9 84508.424 4q21.23
    AGXT2L1 109663.203 4q25
    AIMP1 107236.852 4q24
    AMBN 71457.992 4q21
    ANK2 113739.238 4q25-q27
    ANKRD17 73940.954 4q13.3
    ANP32C 165118.160 4q32.3
    ANXA10 169013.725 4q33
    ANXA3 79523.017 4q21.21
    ANXA5 122589.658 4q26-q28|4q27
    ARFIP1 153750.785 4q31.3
    ARHGAP10 148653.452 4q31.23
    ARHGAP24 86396.303 4q22.1
    ARHGEF38 106473.776 4q24
    ATOH1 94750.076 4q22
    BDH2 104000.633 4q24
    BMP3 81952.167 4q21
    BMPR1B 96012.641 4q22-q24
    BTC 75719.532 4q13-q21
    C1QTNF7 15429.667 4p15.3
    C4orf17 100432.168 4q23
    C4orf21 113527.102 4q25
    C4orf36 87797.412 4q21.3
    CAMK2D 114377.764 4q26
    CASP3 185550.427 4q34
    CASP6 110610.038 4q25
    CCDC110 186366.345 4q35.1
    CCKAR 26483.260 4p15.1-p15.2
    CCNA2 122738.723 4q25-q31
    CCNG2 78089.301 4q21.1
    CCNI 77969.178 4q21.1
    CCRN4L 139936.942 4q31.1
    CDKN2AIP 184365.799 4q35.1
    CENPC1 68359.621 4q13.2
    CFI 110661.851 4q25
    CLOCK 56298.659 4q12
    COL25A1 109734.971 4q25
    COPS4 83956.382 4q21.22
    COQ2 84184.978 4q21.23
    COX7B2 46736.848 4p12
    CRMP1 5822.510 4p16.1
    CSN3 71108.304 4q21.1
    CTBP1 1205.287 4p16
    CXCL10 76942.272 4q21
    CXCL11 76955.389 4q21.2
    CXCL13 78526.985 4q21
    CXCL1 74735.120 4q21
    CXCL2 74963.460 4q21
    CXCL3 74903.126 4q21
    CXCL5 74861.359 4q13.3
    CXCL6 74702.395 4q21
    CXCL9 76924.752 4q21
    CXXC4 105393.344 4q22-q24
    DCK 71859.279 4q13.3-q21.1
    DCLK2 150999.425 4q31.3
    DCTD 183812.277 4q35.1
    DGKQ 952.675 4p16.3
    DKK2 107844.977 4q25
    DNAJB14 100820.703 4q23
    DSPP 88535.200 4q21.3
    EDNRA 148406.985 4q31.22
    ELF2 139979.431 4q28
    ELOVL6 110970.542 4q25
    EMCN 101319.446 4q24
    ENOPH1 83351.762 4q21.22
    ENPP6 185009.859 4q35.1
    EPGN 75174.189 4q13.3
    EPHA5 66196.278 4q13.1
    EREG 75230.859 4q13.3
    EXOC1 56744.177 4q12
    F11 187187.416 4q35
    FABP2 120238.405 4q28-q31
    FAM149A 187070.391 4q35.1
    FAM175A 84383.227 4q21.23
    FAT1 187508.953 4q35
    FAT4 126370.294 4q28.1
    FBXO8 175157.811 4q34.1
    FBXW7 153243.964 4q31.3
    FGA 155506.428 4q28
    FGFBP1 15937.200 4p15.32
    FGFRL1 1005.759 4p16
    FIP1L1 54324.828 4q12
    GAB1 144359.736 4q31.21
    GAK 843.065 4p16
    GC 72607.410 4q12-q13
    GDEP 80748.629 4q21.1
    GNRHR 68606.198 4q21.2
    GRID2 93225.549 4q22
    GRK4 2965.334 4p16.3
    GSTCD 106629.943 4q24
    GSX2 54966.197 4q12
    H2AFZ 100869.242 4q24
    HELT 185939.994 4q35.1
    HERC3 89513.631 4q21
    HERC5 89378.306 4q22.1
    HERC6 89299.890 4q22.1
    HGFAC 3443.701 4p16
    HHIP 145633.133 4q28-q32
    HNRPDL 83345.781 4q21.22
    HPSE 84216.469 4q21.3
    HSD17B11 88257.762 4q22.1
    HSP90AB2P 13335.037 4p15.33
    HSPA4L 128703.650 4q28
    HTRA3 8271.491 4p16.1
    HTT 3076.407 4p16.3
    IGFBP7 57907.002 4q12
    IL15 142640.299 4q31
    IL21 123533.783 4q26-q27
    IL8 74608.854 4q13-q21
    INPP4B 143003.205 4q31.21
    INTS12 106603.786 4q24
    KCNIP4 20731.706 4p15.32
    KDR 55944.649 4q11-q12
    KLHL2 166184.364 4q21.2
    KLKB1 187148.624 4q35
    LEF1 108991.813 4q23-q25
    LETM1 1814.759 4p16.3
    LNX1 54325.467 4q12
    LRAT 155665.282 4q32.1
    LRP2BP 186285.032 4q35.1
    LRPAP1 3514.289 4p16.3
    MAB21L2 151503.435 4q31
    MANBA 103552.659 4q22-q25
    MAPKSP1 100802.370 4q23
    MED28 17616.286 4p16
    MEPE 88754.139 4q21.1
    METAP1 99916.871 4q23
    MMAA 146578.403 4q31.21
    MORF4 174537.088 4q34.1
    MTNR1A 187455.001 4q35.1
    MXD4 2252.034 4p16.3
    MYOZ2 120085.379 4q26-q27
    N4BP2 40104.526 4p14
    NAA11 80238.272 4q21.21
    NAA15 140222.654 4q31.1
    NAAA 76836.058 4q21.1
    NAP1L5 89617.066 4q22.1|4q21-q22
    NBLA00301 174451.609 4q34.1
    NDST3 118955.499 4q26
    NDST4 115748.930 4q26
    NEIL3 178231.107 4q34.3
    NEK1 170314.430 4q33
    NKX6-1 85414.443 4q21.33
    NMU 56465.318 4q12
    NPNT 106890.500 4q24
    NPY2R 156135.049 4q31
    NPY5R 164265.253 4q31-q32
    NUP54 77035.817 4q21.1
    OCIAD1 48833.120 4p11
    ODZ3 183525.715 4q35.1
    OSTC 109571.780 4q25
    PALLD 169753.191 4q32.3
    PAPSS1 108535.404 4q24
    PAQR3 79839.865 4q21.21
    PCDH10 134070.469 4q28.3
    PCDH7 30722.036 4p15
    PDE5A 120419.724 4q27
    PDGFC 157683.793 4q32
    PDHA2 96761.278 4q22-q23
    PDLIM3 186423.097 4q35
    PDS5A 39824.483 4p14
    PHF17 129770.257 4q26-q27
    PI4K2B 25235.785 4p15.2
    PITX2 111538.581 4q25
    PKD2 88996.726 4q21-q23
    PLK4 128802.100 4q28
    POLN 2073.676 4p16.3
    POU4F2 147560.044 4q31.2
    PPARGC1A 23797.324 4p15.1
    PPBP 74852.990 4q12-q13
    PPEF2 76781.027 4q21.1
    PPID 159630.887 4q31.3
    PPM1K 89189.914 4q22.1
    PPP2R2C 6335.372 4p16.1
    PPP3CA 101947.023 4q24
    PRDM5 121615.929 4q25-q26
    PRKG2 82010.751 4q13.1-q21.1
    PTTG2 37962.055 4p12
    RAB28 13371.499 4p15.33
    RAB33B 140375.238 4q28
    RAPGEF2 160189.245 4q32.1
    RASGEF1B 82348.218 4q21.21
    RBPJ 26434.719 4p15.2
    RFC1 39289.717 4p14-p13
    RG9MTD2 100470.105 4q23
    RGS12 3371.723 4p16.3
    RNF150 141786.724 4q31.21
    RNF4 2470.845 4p16.3
    RPL34 109543.159 4q25
    RPS3A 152020.781 4q31.2-q31.3
    RXFP1 159443.127 4q32.1
    SAP30 174292.093 4q34.1
    SEC31A 83739.814 4q21.22
    SETD7 140427.192 4q28
    SGMS2 108745.817 4q25
    SH3BP2 2820.540 4p16.3
    SLC25A4 186064.429 4q35
    SLC26A1 981.772 4p16.3
    SLC7A11 139093.008 4q28-q32
    SLIT2 20255.234 4p15.2
    SMAD1 146465.329 4q31
    SMARCA5 144434.875 4q31.1-q31.2
    SMARCAD1 95128.872 4q22-q23
    SOD3 24797.103 4p15.3-p15.1
    SPARCL1 88394.920 4q22.1
    SPATA4 177105.724 4q34.2
    SPINK2 57676.304 4q12
    SPOCK3 167675.237 4q32.3
    SPON2 1160.722 4p16.3
    SPRY1 124323.286 4q28.1
    SRD5A3 56212.408 4q12
    STAP1 68424.445 4q13.2
    STK32B 5053.526 4p16.2
    STOX2 184826.508 4q35.1
    STX18 4421.202 4p16.3-p16.2
    SULT1E1 70714.843 4q13.1
    SYT14L 68928.259 4q13.2
    TBC1D1 38029.413 4p14
    TBCK 106967.727 4q24
    TET2 106182.914 4q24
    THAP9 83827.720 4q21.22
    TLR10 38774.777 4p14
    TLR1 38798.091 4p14
    TLR2 154624.059 4q32
    TLR3 186997.773 4q35
    TLR6 38828.407 4p14
    TMEM184C 148554.052 4q31.23
    TMPRSS11A 68777.040 4q13.2
    TNIP2 2743.392 4p16.3
    TNIP3 122052.566 4q27
    TRAM1L1 118004.996 4q26
    TRIM60 165953.150 4q32.3
    TRPC3 122800.891 4q27
    TXK 48069.177 4p12
    UBE2D3 103717.290 4q24
    UCHL1 41259.004 4p14
    UGDH 39506.863 4p15.1
    UGT2B7 69962.218 4q13
    UGT8 115519.610 4q26
    UNC5C 96089.688 4q21-q23
    USP17 9364.854 4p15
    VEGFC 177605.084 4q34.3
    WDR19 39217.501 4p14
    WHSC2 1984.452 4p16.3
    WWC2 184187.033 4q35.1
    ZFP42 188923.961 4q35.2

    GeneCards  

    Contributor(s)

    WrittenJul 2004Philippe Dessen, Sakari Knuutila, Jean-Loup Huret
    Updated Jean-Loup Huret, Philippe Dessen

    Citation

    This paper should be referenced as such :
    Dessen P, Knuutila S, Huret JL . Chromosome . Atlas Genet Cytogenet Oncol Haematol. Jul 2004 .
    URL : http://AtlasGeneticsOncology.org/Indexbychrom/idxa_4.html
    Dessen P, Huret JL . Chromosome . Atlas Genet Cytogenet Oncol Haematol. .
    URL : http://AtlasGeneticsOncology.org/Indexbychrom/idxa_4.html
    © Atlas of Genetics and Cytogenetics in Oncology and Haematology
    indexed on : Wed Sep 1 08:31:57 CEST 2010
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