inv(10)(q11q11) NCOA4/RET

0000-00-00   Jean-Loup Huret , Philippe Dessen 

Summary

Note

Non-annotated chromosomal abnormality. Preliminary data :
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Genes Involved and Proteins

Gene name

Location

10q11.22

Gene name

Location

10q11.21

Highly cited references

Pubmed IDYearTitleCitations
231507062012RET fusions define a unique molecular and clinicopathologic subtype of non-small-cell lung cancer.171
238560312013Antitumor activities of the targeted multi-tyrosine kinase inhibitor lenvatinib (E7080) against RET gene fusion-driven tumor models.89
260783372015Identification and characterization of RET fusions in advanced colorectal cancer.43
261874282015Emergence of RET rearrangement co-existing with activated EGFR mutation in EGFR-mutated NSCLC patients who had progressed on first- or second-generation EGFR TKI.41
304466522018RET rearrangements are actionable alterations in breast cancer.37
317154212019RET fusions in solid tumors.35
290768772018The Role of Molecular Testing in the Differential Diagnosis of Salivary Gland Carcinomas.34
273348352016Profiling of 149 Salivary Duct Carcinomas, Carcinoma Ex Pleomorphic Adenomas, and Adenocarcinomas, Not Otherwise Specified Reveals Actionable Genomic Alterations.32
280114612017Antitumor Activity of RXDX-105 in Multiple Cancer Types with RET Rearrangements or Mutations.30
316539702019Genomic characterization of intrinsic and acquired resistance to cetuximab in colorectal cancer patients.28
300450652018Molecular Profiling of Salivary Gland Intraductal Carcinoma Revealed a Subset of Tumors Harboring NCOA4-RET and Novel TRIM27-RET Fusions: A Report of 17 cases.26
292841532018Role of RET protein-tyrosine kinase inhibitors in the treatment RET-driven thyroid and lung cancers.25
327374492020Clinicopathologic features of kinase fusion-related thyroid carcinomas: an integrative analysis with molecular characterization.24
266600782016Identification of Targetable Kinase Alterations in Patients with Colorectal Carcinoma That are Preferentially Associated with Wild-Type RAS/RAF.22
311622842019NCOA4-RET and TRIM27-RET Are Characteristic Gene Fusions in Salivary Intraductal Carcinoma, Including Invasive and Metastatic Tumors: Is "Intraductal" Correct?21
276266722016Drosophila Cancer Models Identify Functional Differences between Ret Fusions.21
294430142018Recurrent RET Gene Rearrangements in Intraductal Carcinomas of Salivary Gland.18
301306302019Novel gene fusions in secretory carcinoma of the salivary glands: enlarging the ETV6 family.16
316978652020Intraductal carcinomas of the salivary glands: systematic review and classification of 93 published cases.12
326616692021Salivary Intraductal Carcinoma Arising within Intraparotid Lymph Node: A Report of 4 Cases with Identification of a Novel STRN-ALK Fusion.10
331351962021Oncocytic intraductal carcinoma of salivary glands: a distinct variant with TRIM33-RET fusions and BRAF V600E mutations.8
332729812021A Performance Comparison of Commonly Used Assays to Detect RET Fusions.7
302106252018NCOA4-RET fusion in colorectal cancer: Therapeutic challenge using patient-derived tumor cell lines.7
290887432017In vitro and in vivo anti-tumor activity of alectinib in tumor cells with NCOA4-RET.6
338270482021Pan-genomic characterization of high-risk pediatric papillary thyroid carcinoma.5
330862362021The Myoepithelial Cells of Salivary Intercalated Duct-type Intraductal Carcinoma Are Neoplastic: A Study Using Combined Whole-slide Imaging, Immunofluorescence, and RET Fluorescence In Situ Hybridization.5
345081692021Genomic characterization and outcome evaluation of kinome fusions in lung cancer revealed novel druggable fusions.4
337484792021DNA repair pathway activation features in follicular and papillary thyroid tumors, interrogated using 95 experimental RNA sequencing profiles.4
254075642015An evaluation and recommendation of the optimal methodologies to detect RET gene rearrangements in papillary thyroid carcinoma.4
321623062020Receptor tyrosine kinase fusions act as a significant alternative driver of the serrated pathway in colorectal cancer development.3
309388802019S100 and CD34 positive spindle cell tumor with prominent perivascular hyalinization and a novel NCOA4-RET fusion.3
337499502021Histology-based molecular profiling improves mutation detection for advanced thyroid cancer.2
339915272021Intraductal carcinoma of the salivary gland with NCOA4-RET: expanding the morphologic spectrum and an algorithmic diagnostic approach.2
335262152021Intraductal Carcinomas of the Salivary Gland.2
286521692018Oncogene-induced senescence and its evasion in a mouse model of thyroid neoplasia.2
349856832022Frankly Invasive Carcinoma Ex-intraductal Carcinoma: Expanding on an Emerging and Perplexing Concept in Salivary Gland Tumor Pathology.1
345625022021Genomic characterization of hepatoid tumors: context matters.1
357148342022Hepatoid tumors of the gastrointestinal/pancreatobiliary district: morphology, immunohistochemistry, and molecular profiles.0
354781342022Clinical Utility of Next-generation Sequencing in Real-world Cases: A Single-institution Study of Nine Cases.0
340094522021A rare case of high-grade intraductal carcinoma of the upper lip: immunohistochemical and genetic analyses.0
345974582021Cytomorphologic features of intraductal salivary gland carcinoma: A multi-institutional study of 13 FNA cases with histologic, molecular, and clinical correlations.0

Bibliography

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Citation

Jean-Loup Huret ; Philippe Dessen

inv(10)(q11q11) NCOA4/RET

Atlas Genet Cytogenet Oncol Haematol. 0000-00-00

Online version: http://atlasgeneticsoncology.org/solid-tumor/5466/inv(10)(q11q11)-ncoa4-ret