t(2;7)(p23;q11) HIP1/ALK

0000-00-00   Jean-Loup Huret , Philippe Dessen 

(Note: the fusion was discovered by NGS. Many chromosome rearrangement mechanisms such as translocation, inversion,deletion or complex rearrangement may lead to the same fusion)

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to u00a0How to contribute

Summary

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to  How to contribute

Genes Involved and Proteins

Gene name

HIP1

Location

7q11.23

Gene name

ALK

Location

2p23.2

Highly cited references

Pubmed IDYearTitleCitations
255679082015Broad, Hybrid Capture-Based Next-Generation Sequencing Identifies Actionable Genomic Alterations in Lung Adenocarcinomas Otherwise Negative for Such Alterations by Other Genomic Testing Approaches.102
253937962014Identification of a novel HIP1-ALK fusion variant in Non-Small-Cell Lung Cancer (NSCLC) and discovery of ALK I1171 (I1171N/S) mutations in two ALK-rearranged NSCLC patients with resistance to Alectinib.36
244960032014HIP1-ALK, a novel ALK fusion variant that responds to crizotinib.29
245180942014HIP1-ALK, a novel fusion protein identified in lung adenocarcinoma.25
273434442016Custom Gene Capture and Next-Generation Sequencing to Resolve Discordant ALK Status by FISH and IHC in Lung Adenocarcinoma.10
318943862020Unique molecular features and clinical outcomes in young patients with non-small cell lung cancer harboring ALK fusion genes.9
332809262021A novel HIP1-ALK fusion variant in lung adenocarcinoma showing resistance to Crizotinib.3
352426312022High efficacy of alectinib in a patient with advanced lung adenocarcinoma with 2 rare ALK fusion sites: a case report.1
346874882022Clinicopathological features and resistance mechanisms in HIP1-ALK-rearranged lung cancer: A multicenter study.0
349410392021Identification of triple gene fusion ALK-LRRN2, LTBP1-ALK, and HIP1-ALK in advanced lung adenocarcinoma and response to alectinib: A case report.0
315940412019[The characteristics of lung adenocarcinoma driver gene variants detected by high-throughput sequencing and quantitative fluorescence PCR].0

Bibliography

Pubmed IDLast YearTitleAuthors
244960032014HIP1-ALK, a novel ALK fusion variant that responds to crizotinib.Fang DD et al
245180942014HIP1-ALK, a novel fusion protein identified in lung adenocarcinoma.Hong M et al

Citation

Jean-Loup Huret ; Philippe Dessen

t(2;7)(p23;q11) HIP1/ALK

Atlas Genet Cytogenet Oncol Haematol. 0000-00-00

Online version: http://atlasgeneticsoncology.org/solid-tumor/105499/t(2;7)(p23;q11)-hip1-alk