t(5;8)(q33;p12) CD74/NRG1

0000-00-00   Jean-Loup Huret , Philippe Dessen 

(Note: the fusion was discovered by NGS. Many chromosome rearrangement mechanisms such as translocation, inversion,deletion or complex rearrangement may lead to the same fusion)

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to u00a0How to contribute

Summary

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to  How to contribute

Genes Involved and Proteins

Gene name

Location

5q33.1

Gene name

Location

8p12

Highly cited references

Pubmed IDYearTitleCitations
244691082014CD74-NRG1 fusions in lung adenocarcinoma.89
247273202014Druggable oncogene fusions in invasive mucinous lung adenocarcinoma.69
262002692015Unique Genetic and Survival Characteristics of Invasive Mucinous Adenocarcinoma of the Lung.63
255314672014Transcriptome meta-analysis of lung cancer reveals recurrent aberrations in NRG1 and Hippo pathway genes.57
264860772015Comprehensive investigation of oncogenic driver mutations in Chinese non-small cell lung cancer patients.40
268377692016Oncogenic Fusion Gene CD74-NRG1 Confers Cancer Stem Cell-like Properties in Lung Cancer through a IGF2 Autocrine/Paracrine Circuit.28
276263122016Oncogenic function and clinical implications of SLC3A2-NRG1 fusion in invasive mucinous adenocarcinoma of the lung.23
313820392019Detection of Novel NRG1, EGFR, and MET Fusions in Lung Adenocarcinomas in the Chinese Population.16
329162652020NRG1 fusion-driven tumors: biology, detection, and the therapeutic role of afatinib and other ErbB-targeting agents.15
291695242017A Case of Invasive Mucinous Pulmonary Adenocarcinoma with a CD74-NRG1 Fusion Protein Targeted with Afatinib.13
295157612018Frequent NRG1 fusions in Caucasian pulmonary mucinous adenocarcinoma predicted by Phospho-ErbB3 expression.10
309147782019A combined gene expression tool for parallel histological prediction and gene fusion detection in non-small cell lung cancer.9
249138072014Multidriver mutation analysis in pulmonary mucinous adenocarcinoma in Taiwan: identification of a rare CD74-NRG1 translocation case.9
271887222016Discovery of ERBB3 inhibitors for non-small cell lung cancer (NSCLC) via virtual screening.7
338241662021The Anti-HER3 mAb Seribantumab Effectively Inhibits Growth of Patient-Derived and Isogenic Cell Line and Xenograft Models with Oncogenic NRG1 Fusions.4
298582242018ERBB Signaling Interrupted: Targeting Ligand-Induced Pathway Activation.4
351358292022Zenocutuzumab, a HER2xHER3 Bispecific Antibody, Is Effective Therapy for Tumors Driven by NRG1 Gene Rearrangements.3
337969132021Comprehensive analysis of the clinicopathological features, targetable profile, and prognosis of mucinous adenocarcinoma of the lung.1
348053692021Successful targeting of the NRG1 fusion reveals durable response to afatinib in lung adenocarcinoma: a case report.1
341324502021A Phase I, First-in-Human Study of GSK2849330, an Anti-HER3 Monoclonal Antibody, in HER3-Expressing Solid Tumors.1
251211642014[CD74-NRG1: a new fusion gene in lung adenocarcinomas characterizing mucinous adenocarcinomas].1
352479252022CD74-NRG1 Fusions Are Oncogenic In Vivo and Induce Therapeutically Tractable ERBB2:ERBB3 Heterodimerization.0

Bibliography

Pubmed IDLast YearTitleAuthors
244691082014CD74-NRG1 fusions in lung adenocarcinoma.Fernandez-Cuesta L et al
249138072014Multidriver mutation analysis in pulmonary mucinous adenocarcinoma in Taiwan: identification of a rare CD74-NRG1 translocation case.Gow CH et al

Citation

Jean-Loup Huret ; Philippe Dessen

t(5;8)(q33;p12) CD74/NRG1

Atlas Genet Cytogenet Oncol Haematol. 0000-00-00

Online version: http://atlasgeneticsoncology.org/solid-tumor/106825/t(5;8)(q33;p12)-cd74-nrg1