t(7;7)(p21;q34) TMEM106B/BRAF

0000-00-00   Jean-Loup Huret , Philippe Dessen 

(Note: the fusion was discovered by NGS. Many chromosome rearrangement mechanisms such as translocation, inversion,deletion or complex rearrangement may lead to the same fusion)

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to u00a0How to contribute

Summary

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to  How to contribute

Genes Involved and Proteins

Gene name

TMEM106B

Location

7p21.3

Gene name

Location

7q34

Highly cited references

Pubmed IDYearTitleCitations
280698022017Genomic Profiling of a Large Set of Diverse Pediatric Cancers Identifies Known and Novel Mutations across Tumor Spectra.31
282993582017A novel, potentially targetable TMEM106B-BRAF fusion in pleomorphic xanthoastrocytoma.9
357389422022Primary pancreatic spindle cell sarcoma with a TMEM106B::BRAF gene fusion treated with MEK inhibition.0

Bibliography

Pubmed IDLast YearTitleAuthors
282993582017A novel, potentially targetable TMEM106B-BRAF fusion in pleomorphic xanthoastrocytoma.Hsiao SJ et al

Citation

Jean-Loup Huret ; Philippe Dessen

t(7;7)(p21;q34) TMEM106B/BRAF

Atlas Genet Cytogenet Oncol Haematol. 0000-00-00

Online version: http://atlasgeneticsoncology.org/solid-tumor/107599/t(7;7)(p21;q34)-tmem106b-braf