t(7;15)(p11;q15) EGFR/RAD51

0000-00-00   Jean-Loup Huret , Philippe Dessen 

(Note: the fusion was discovered by NGS. Many chromosome rearrangement mechanisms such as translocation, inversion,deletion or complex rearrangement may lead to the same fusion)

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to u00a0How to contribute

Summary

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to  How to contribute

Genes Involved and Proteins

Gene name

EGFR

Location

7p11.2

Gene name

RAD51

Location

15q15.1

Highly cited references

Pubmed IDYearTitleCitations
271020762016EGFR Fusions as Novel Therapeutic Targets in Lung Cancer.40
274137142016Kinase inhibitor-responsive genotypes in EGFR mutated lung adenocarcinomas: moving past common point mutations or indels into uncommon kinase domain duplications and rearrangements.22
294720542018EGFR-RAD51 Fusion: A Targetable Partnership Originated from the Tumor Evolution?10
292902552018EGFR-RAD51 fusion variant in lung adenocarcinoma and response to erlotinib: A case report.10
310648872019Effectiveness of EGFR-TKIs in a Patient with Lung Adenocarcinoma Harboring an EGFR-RAD51 Fusion.7
318656382020Chemotherapy combined with bevacizumab for the treatment of advanced lung adenocarcinoma cancer harboring EGFR-ANXA2, EGFR-RAD51, ATR and BRCA2 mutations: A case report.5
343420912021Gefitinib Combined with Cetuximab for the Treatment of Lung Adenocarcinoma Harboring the EGFR-Intergenic Region (SEC61G) Fusion and EGFR Amplification.2
354781342022Clinical Utility of Next-generation Sequencing in Real-world Cases: A Single-institution Study of Nine Cases.0
352458452022EGFR-RAD51 fusion in lung adenocarcinoma with systemic and intracranial response to osimertinib: A case report and review of the literature.0
353995742022EGFR-RAD51 gene fusion NSCLC responsiveness to different generation EGFR-TKIs: two cases and review of the literature.0

Bibliography

Pubmed IDLast YearTitleAuthors
271020762016EGFR Fusions as Novel Therapeutic Targets in Lung Cancer.Konduri K et al

Citation

Jean-Loup Huret ; Philippe Dessen

t(7;15)(p11;q15) EGFR/RAD51

Atlas Genet Cytogenet Oncol Haematol. 0000-00-00

Online version: http://atlasgeneticsoncology.org/solid-tumor/107430/t(7;15)(p11;q15)-egfr-rad51