t(17;22)(p13;q12) MYH9/USP6

0000-00-00   Jean-Loup Huret , Philippe Dessen 

(Note: the fusion was discovered by NGS. Many chromosome rearrangement mechanisms such as translocation, inversion,deletion or complex rearrangement may lead to the same fusion)

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to u00a0How to contribute

Summary

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to  How to contribute

Genes Involved and Proteins

Gene name

MYH9

Location

22q12.3

Gene name

USP6

Location

17p13.2

Highly cited references

Pubmed IDYearTitleCitations
218260562011Nodular fasciitis: a novel model of transient neoplasia induced by MYH9-USP6 gene fusion.54
291040832018Development and Evaluation of a Pan-Sarcoma Fusion Gene Detection Assay Using the NanoString nCounter Platform.19
287528422017USP6 activation in nodular fasciitis by promoter-swapping gene fusions.16
271253572016USP6 genetic rearrangements in cellular fibroma of tendon sheath.8
321704502020Novel CTNNB1-USP6 fusion in intravascular fasciitis of the large vein identified by next-generation sequencing.6
315383902019Case of mesenchymal tumor with the PPP6R3-USP6 fusion, possible nodular fasciitis with malignant transformation.6
318272312020Recurrent and novel USP6 fusions in cranial fasciitis identified by targeted RNA sequencing.5
306116322021Two case reports of intra-articular nodular fasciitis of the knee confirmed by MYH9-USP6 gene fusion expression.4
330004812021Clinicopathological and molecular characterisation of USP6-rearranged soft tissue neoplasms: the evidence of genetic relatedness indicates an expanding family with variable bone-forming capacity.3
268820592017Nodular Fasciitis of the Orbit: A Case Report Confirmed by Molecular Cytogenetic Analysis.3
276866472016Cutaneous nodular fasciitis with genetic analysis: a case series.2
340998722021Nodular fasciitis of the breast: clinicopathologic and molecular characterization with identification of novel USP6 fusion partners.1
343811872021Nodular fasciitis: a comprehensive, time-correlated investigation of 17 cases.0
339156542021[Nodular fasciitis of the breast: a clinicopathological and genetic analysis of seven cases].0
334048532021Intraarticular nodular fasciitis-detection of USP6 gene fusions in three cases by targeted RNA sequencing.0
332822852021An aggressive nodular fasciitis lesion protruding from the palm (USP6 gene fusion helps differentiate from sarcomas): A case report.0
320890282020Intraarticular Nodular Fasciitis of the Knee With MHY9-USP6 Fusion: A Case Report.0
253461232014[Chromosomal translocation involving USP6 gene in nodular fasciitis].0

Bibliography

Pubmed IDLast YearTitleAuthors
218260562011Nodular fasciitis: a novel model of transient neoplasia induced by MYH9-USP6 gene fusion.Erickson-Johnson MR et al

Citation

Jean-Loup Huret ; Philippe Dessen

t(17;22)(p13;q12) MYH9/USP6

Atlas Genet Cytogenet Oncol Haematol. 0000-00-00

Online version: http://atlasgeneticsoncology.org/solid-tumor/102979/t(17;22)(p13;q12)-myh9-usp6