t(2;22)(p23;q12) TIMP3/ALK

0000-00-00   Jean-Loup Huret  , Philippe Dessen  

(Note: the fusion was discovered by NGS. Many chromosome rearrangement mechanisms such as translocation, inversion,deletion or complex rearrangement may lead to the same fusion)

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to u00a0How to contribute

Summary

Note

Non-annotated chromosomal abnormality. Preliminary data :
if you are an author who wish to write a full paper/card on this translocation,go to  How to contribute

Genes Involved and Proteins

Gene name

Location

22q12.3

Gene name

Location

2p23.2

Highly cited references

Pubmed IDYearTitleCitations
359253902022TIMP3::ALK fusions characterize a distinctive myxoid fibroblastic tumor of the vocal cords: a report of 7 cases.0
329711282020Inflammatory myofibroblastic tumors associated with the placenta: a series of 9 cases.0
322711872020Pregnancy-associated Inflammatory Myofibroblastic Tumors of the Uterus Are Clinically Distinct and Highly Enriched for TIMP3-ALK and THBS1-ALK Fusions.0
284900452017Uterine Inflammatory Myofibroblastic Tumors Frequently Harbor ALK Fusions With IGFBP5 and THBS1.0
312151302019Vocal cord inflammatory myofibroblastic tumor with mucoid deposits harboring TIMP3-ALK fusion: A potential diagnostic pitfall.0
319171552020Uterine inflammatory myofibroblastic tumors in pregnant women with and without involvement of the placenta: a study of 6 cases with identification of a novel TIMP3-RET fusion.0

Article Bibliography

Pubmed IDLast YearTitleAuthors
284900452017Uterine Inflammatory Myofibroblastic Tumors Frequently Harbor ALK Fusions With IGFBP5 and THBS1.Haimes JD et al

Citation

Jean-Loup Huret ; Philippe Dessen

t(2;22)(p23;q12) TIMP3/ALK

Atlas Genet Cytogenet Oncol Haematol. 0000-00-00

Online version: http://atlasgeneticsoncology.org/solid-tumor/105421/t(2;22)(p23;q12)-timp3-alk