t(11;22)(q24;q12) MN1/FLI1

2018-01-01   Jean-Loup Huret , Philippe Dessen 

Clinics and Pathology

Disease

Acute megakaryoblastic leukemia (FAB type M7)

Genes Involved and Proteins

Gene name
MN1
Location
22q12.1
Gene name
FLI1
Location
11q24.3

Highly cited references

Pubmed IDYearTitleCitations
281744172017AMKL chimeric transcription factors are potent inducers of leukemia.16
266905452015MN1-Fli1 oncofusion transforms murine hematopoietic progenitor cells into acute megakaryoblastic leukemia cells.5

Bibliography

Pubmed IDLast YearTitleAuthors
231535402012An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia.Gruber TA et al
281127372017Pediatric non-Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes.de Rooij JD et al

Summary

Fusion gene

MN1/FLI1 MN1 (22q12.1) FLI1 (11q24.3)

Note

Non-annotated chromosomal abnormality. Preliminary data :
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Citation

Jean-Loup Huret ; Philippe Dessen

t(11;22)(q24;q12) MN1/FLI1

Atlas Genet Cytogenet Oncol Haematol. 2018-01-01

Online version: http://atlasgeneticsoncology.org/haematological/2972/t(11;22)(q24;q12)-mn1-fli1